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Article: Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults

TitleDetection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults
Authors
KeywordsSequencing
Virome
HIV
Microbiome
Issue Date2012
Citation
Clinical Microbiology and Infection, 2012, v. 18, n. 11, p. 1126-1133 How to Cite?
AbstractA low level of CD4+ lymphocyte cells makes end-stage HIV/AIDS patients highly susceptible to microbial infections. We have adopted the next generation sequencing method to identify the spectrum of bacterial plasma and viral elements that might be present in these patients. The HIV/AIDS plasma microbiome was dominated by bacterial elements in the taxonomical order Pseudomonadales, while healthy people carried fewer bacterial DNA in the plasma. We have found that many of the bacterial elements in HIV/AIDS plasma are similar to those of the microbes found in the human gut, suggesting potential acquisition of microbial elements from the gut. The HIV/AIDS and normal plasma DNA virome shared some similarities in the presence of common ubiquitous eukaryotic viruses. The normal DNA virome was mainly composed of viruses from Anelloviridae. In contrast, the HIV/AIDS DNA virome contained a large proportion of bacteriophages, endogenous retroviruses and a non-human virus. In addition, several sequences, which might belong to novel bacteria or endogenous retroviruses, were identified. Taken together, the use of high-throughput sequencing technology in unveiling microbial metagenomics may facilitate future research in combating HIV/AIDS and its associated microbial complications. © 2011 European Society of Clinical Microbiology and Infectious Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/222135
ISSN
2015 Impact Factor: 4.575
2015 SCImago Journal Rankings: 2.530

 

DC FieldValueLanguage
dc.contributor.authorLi, S. K.-
dc.contributor.authorLeung, R. K K-
dc.contributor.authorGuo, H. X.-
dc.contributor.authorWei, J. F.-
dc.contributor.authorWang, J. H.-
dc.contributor.authorKwong, K. T.-
dc.contributor.authorLee, S. S.-
dc.contributor.authorZhang, C.-
dc.contributor.authorTsui, S. K W-
dc.date.accessioned2015-12-21T06:48:49Z-
dc.date.available2015-12-21T06:48:49Z-
dc.date.issued2012-
dc.identifier.citationClinical Microbiology and Infection, 2012, v. 18, n. 11, p. 1126-1133-
dc.identifier.issn1198-743X-
dc.identifier.urihttp://hdl.handle.net/10722/222135-
dc.description.abstractA low level of CD4+ lymphocyte cells makes end-stage HIV/AIDS patients highly susceptible to microbial infections. We have adopted the next generation sequencing method to identify the spectrum of bacterial plasma and viral elements that might be present in these patients. The HIV/AIDS plasma microbiome was dominated by bacterial elements in the taxonomical order Pseudomonadales, while healthy people carried fewer bacterial DNA in the plasma. We have found that many of the bacterial elements in HIV/AIDS plasma are similar to those of the microbes found in the human gut, suggesting potential acquisition of microbial elements from the gut. The HIV/AIDS and normal plasma DNA virome shared some similarities in the presence of common ubiquitous eukaryotic viruses. The normal DNA virome was mainly composed of viruses from Anelloviridae. In contrast, the HIV/AIDS DNA virome contained a large proportion of bacteriophages, endogenous retroviruses and a non-human virus. In addition, several sequences, which might belong to novel bacteria or endogenous retroviruses, were identified. Taken together, the use of high-throughput sequencing technology in unveiling microbial metagenomics may facilitate future research in combating HIV/AIDS and its associated microbial complications. © 2011 European Society of Clinical Microbiology and Infectious Diseases.-
dc.languageeng-
dc.relation.ispartofClinical Microbiology and Infection-
dc.subjectSequencing-
dc.subjectVirome-
dc.subjectHIV-
dc.subjectMicrobiome-
dc.titleDetection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1469-0691.2011.03690.x-
dc.identifier.pmid22084916-
dc.identifier.scopuseid_2-s2.0-84867723488-
dc.identifier.volume18-
dc.identifier.issue11-
dc.identifier.spage1126-
dc.identifier.epage1133-
dc.identifier.eissn1469-0691-

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