File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression

TitleSustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression
Authors
Issue Date2012
Citation
Diabetes, 2012, v. 61, n. 4, p. 933-943 How to Cite?
AbstractDiabetes and obesity are complex diseases associated with insulin resistance and fatty liver. The latter is characterized by dysregulation of the Akt, AMP-activated protein kinase (AMPK), and IGF-I pathways and expression of microRNAs (miRNAs). In China, multicomponent traditional Chinese medicine (TCM) has been used to treat diabetes for centuries. In this study, we used a three-herb, berberine-containing TCM to treat male Zucker diabetic fatty rats. TCM showed sustained glucose-lowering effects for 1 week after a single-dose treatment. Two-week treatment attenuated insulin resistance and fatty degeneration, with hepatocyte regeneration lasting for 1 month posttreatment. These beneficial effects persisted for 1 year after 1-month treatment. Two-week treatment with TCM was associated with activation of AMPK, Akt, and insulin-like growth factor-binding protein (IGFBP)1 pathways, with downregulation of miR29-b and expression of a gene network implicated in cell cycle, intermediary, and NADPH metabolism with normalization of CYP7a1 and IGFBP1 expression. These concerted changes in mRNA, miRNA, and proteins may explain the sustained effects of TCM in favor of cell survival, increased glucose uptake, and lipid oxidation/ catabolism with improved insulin sensitivity and liver regeneration. These novel findings suggest that multicomponent TCM may be a useful tool to unravel genome regulation and expression in complex diseases. © 2012 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/222119
ISSN
2015 Impact Factor: 8.784
2015 SCImago Journal Rankings: 5.185

 

DC FieldValueLanguage
dc.contributor.authorZhao, Hai Lu-
dc.contributor.authorSui, Yi-
dc.contributor.authorQiao, Chun Feng-
dc.contributor.authorYip, Kevin Y.-
dc.contributor.authorLeung, Ross K K-
dc.contributor.authorTsui, Stephen K W-
dc.contributor.authorLee, Heung Man-
dc.contributor.authorWong, Harriet K T-
dc.contributor.authorZhu, Xun-
dc.contributor.authorSiu, Jennifer J.-
dc.contributor.authorHe, Lan-
dc.contributor.authorGuan, Jing-
dc.contributor.authorLiu, Li Zhong-
dc.contributor.authorXu, Hong Xi-
dc.contributor.authorTong, Peter C Y-
dc.contributor.authorChan, Juliana C N-
dc.date.accessioned2015-12-21T06:48:37Z-
dc.date.available2015-12-21T06:48:37Z-
dc.date.issued2012-
dc.identifier.citationDiabetes, 2012, v. 61, n. 4, p. 933-943-
dc.identifier.issn0012-1797-
dc.identifier.urihttp://hdl.handle.net/10722/222119-
dc.description.abstractDiabetes and obesity are complex diseases associated with insulin resistance and fatty liver. The latter is characterized by dysregulation of the Akt, AMP-activated protein kinase (AMPK), and IGF-I pathways and expression of microRNAs (miRNAs). In China, multicomponent traditional Chinese medicine (TCM) has been used to treat diabetes for centuries. In this study, we used a three-herb, berberine-containing TCM to treat male Zucker diabetic fatty rats. TCM showed sustained glucose-lowering effects for 1 week after a single-dose treatment. Two-week treatment attenuated insulin resistance and fatty degeneration, with hepatocyte regeneration lasting for 1 month posttreatment. These beneficial effects persisted for 1 year after 1-month treatment. Two-week treatment with TCM was associated with activation of AMPK, Akt, and insulin-like growth factor-binding protein (IGFBP)1 pathways, with downregulation of miR29-b and expression of a gene network implicated in cell cycle, intermediary, and NADPH metabolism with normalization of CYP7a1 and IGFBP1 expression. These concerted changes in mRNA, miRNA, and proteins may explain the sustained effects of TCM in favor of cell survival, increased glucose uptake, and lipid oxidation/ catabolism with improved insulin sensitivity and liver regeneration. These novel findings suggest that multicomponent TCM may be a useful tool to unravel genome regulation and expression in complex diseases. © 2012 by the American Diabetes Association.-
dc.languageeng-
dc.relation.ispartofDiabetes-
dc.titleSustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.2337/db11-1164-
dc.identifier.pmid22396199-
dc.identifier.scopuseid_2-s2.0-84859542680-
dc.identifier.volume61-
dc.identifier.issue4-
dc.identifier.spage933-
dc.identifier.epage943-
dc.identifier.eissn1939-327X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats