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Article: An unusual cluster of HIV-1 B/F recombinants in an Asian population

TitleAn unusual cluster of HIV-1 B/F recombinants in an Asian population
Authors
KeywordsHIV-1
Macao
Molecular epidemiology
Recombinant
IDU
Issue Date2010
Citation
International Journal of Infectious Diseases, 2010, v. 14, n. SUPPL. 3, p. e294-e298 How to Cite?
AbstractWe report the detection of multiple HIV strains in injection drug users (IDU) in Macao, which appear to be derived from subtypes F, G, and CRF12_BF. A total of 14 HIV-infected IDU samples were collected and examined. Direct sequencing was performed to obtain the gag, pol, and env fragments. The subtypes of individual viral sequences were determined using the REGA subtyping tool. The concatenated sequences were aligned with reference sequences retrieved from the Los Alamos National Laboratory HIV database. We found 11 unusual cases in Macao, which showed characteristics of CRF12_BF (n= 2) and CRF14_BG (n= 8), and one that could not be classified into an existing subtype/CRF, along with three cases of CRF01_AE. Interestingly, the sequences derived from subtypes BG and BF recombinants have not been previously reported in any other Asian cities. Another subtype, CRF14_BG, has also been introduced into Macao among the IDUs. In conclusion, human activity, including travel over long distances and injection drug usage have fueled the spread of HIV and have provided a platform for recombination, which may otherwise have taken years to happen. © 2010 International Society for Infectious Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/222105
ISSN
2015 Impact Factor: 2.229
2015 SCImago Journal Rankings: 1.148

 

DC FieldValueLanguage
dc.contributor.authorLeung, Ross K K-
dc.contributor.authorFong, Fion N Y-
dc.contributor.authorAu, Thomas C C-
dc.contributor.authorLau, I. Fan-
dc.contributor.authorChan, Paul K S-
dc.contributor.authorZhang, Chiyu-
dc.contributor.authorIp, Peng Kei-
dc.contributor.authorLam, Chong-
dc.contributor.authorLee, Shui Shan-
dc.contributor.authorTsui, Stephen K W-
dc.date.accessioned2015-12-21T06:47:50Z-
dc.date.available2015-12-21T06:47:50Z-
dc.date.issued2010-
dc.identifier.citationInternational Journal of Infectious Diseases, 2010, v. 14, n. SUPPL. 3, p. e294-e298-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://hdl.handle.net/10722/222105-
dc.description.abstractWe report the detection of multiple HIV strains in injection drug users (IDU) in Macao, which appear to be derived from subtypes F, G, and CRF12_BF. A total of 14 HIV-infected IDU samples were collected and examined. Direct sequencing was performed to obtain the gag, pol, and env fragments. The subtypes of individual viral sequences were determined using the REGA subtyping tool. The concatenated sequences were aligned with reference sequences retrieved from the Los Alamos National Laboratory HIV database. We found 11 unusual cases in Macao, which showed characteristics of CRF12_BF (n= 2) and CRF14_BG (n= 8), and one that could not be classified into an existing subtype/CRF, along with three cases of CRF01_AE. Interestingly, the sequences derived from subtypes BG and BF recombinants have not been previously reported in any other Asian cities. Another subtype, CRF14_BG, has also been introduced into Macao among the IDUs. In conclusion, human activity, including travel over long distances and injection drug usage have fueled the spread of HIV and have provided a platform for recombination, which may otherwise have taken years to happen. © 2010 International Society for Infectious Diseases.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Infectious Diseases-
dc.subjectHIV-1-
dc.subjectMacao-
dc.subjectMolecular epidemiology-
dc.subjectRecombinant-
dc.subjectIDU-
dc.titleAn unusual cluster of HIV-1 B/F recombinants in an Asian population-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijid.2010.01.003-
dc.identifier.pmid20430662-
dc.identifier.scopuseid_2-s2.0-77957345123-
dc.identifier.volume14-
dc.identifier.issueSUPPL. 3-
dc.identifier.spagee294-
dc.identifier.epagee298-

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