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Conference Paper: Non-anaplastic peripheral T-cell lymphoma in children and adolescents - International review

TitleNon-anaplastic peripheral T-cell lymphoma in children and adolescents - International review
Authors
Issue Date2015
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
The International Symposium on Childhood, Adolescent and. Young Adult Non-Hodgkin Lymphoma, Varese, Italy, 21-24 October 2015. In British Journal of Haematology, 2015, v. 171 suppl. S1, p. 13, abstract no. 19 How to Cite?
AbstractBACKGROUND: Non-anaplastic peripheral T-cell lymphomas (PTCL) are rare in the pediatric population and little is known about outcome and treatment options. OBJECTIVES: The present study is a joint, international, retrospective review of reported cases of PTCL in patients below 18 years, with focus on treatment options and outcome. Design/Methods: Only cases reviewed by national or international reference pathologists have been included. RESULTS: Until now, 122 patients diagnosed between 1995 and 2015 have been included in the study. The frequency of PTCL in the population-based reports (western Europe) was around 1%, which is lower than reported in older publications where Alk+ ALCL were included in this group. Patients were treated according to different treatment regimens, classified as B-cell type, T-cell type or other. pOS at 5 years for the group was at 54% and pEFS at 45%. 28 patients were reported to have a pre-existing disease and this group of patients had worse outcome with pOS at 5 years of 29%. PTCL NOS was the largest subtype, with 53 patients, followed by extranodal NK/T-cell lymphoma, nasal type (n = 21), hepatosplenic T-cell lymphoma (n = 16) and subcutaneous panniculitis-like T-cell lymphoma (n = 12). Patients with subcutaneous panniculitis-like T-cell lymphoma had a good outcome with a p OS at 5 years of 83% while patients with hepatosplenic T-cell lymphoma were reported with only pOS of only 16%. There was no clear difference in outcome between patients treated with a B-cell type or a T-cell type of treatment but in general outcome after CHOP/CHOEP appeared to be inferior. CONCLUSION: PTCL is a heterogeneous group of diseases where PTCL NOS is the largest subgroup. Pre -existing medical condition was reported in 25% of the cases and was associated with a poor treatment result. There is a clear need for disease-based treatment recommendation for this group of patients.
DescriptionThis free journal suppl. entitled: Special Issue: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma Abstracts, 22 October 2015, Varese, Italy
Peer-reviewed Oral Presentation
Persistent Identifierhttp://hdl.handle.net/10722/222040
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313

 

DC FieldValueLanguage
dc.contributor.authorMellgren, K-
dc.contributor.authorChiang, A-
dc.contributor.authorAbla, O-
dc.contributor.authorAlexander, S-
dc.contributor.authorPlat, G-
dc.contributor.authorMyakova, N-
dc.contributor.authorMeyer-Wentrup, F-
dc.contributor.authorKobayashi, R-
dc.contributor.authorPillon, M-
dc.contributor.authorBubanska, E-
dc.contributor.authorKabickov, E-
dc.contributor.authorKrenova, Z-
dc.contributor.authorFedorova, A-
dc.contributor.authorWrobel, G-
dc.contributor.authorKlapper, W-
dc.contributor.authorWilliams, D-
dc.contributor.authorAttarbasch, A-
dc.contributor.authorKontny, U-
dc.date.accessioned2015-12-21T05:53:25Z-
dc.date.available2015-12-21T05:53:25Z-
dc.date.issued2015-
dc.identifier.citationThe International Symposium on Childhood, Adolescent and. Young Adult Non-Hodgkin Lymphoma, Varese, Italy, 21-24 October 2015. In British Journal of Haematology, 2015, v. 171 suppl. S1, p. 13, abstract no. 19-
dc.identifier.issn0007-1048-
dc.identifier.urihttp://hdl.handle.net/10722/222040-
dc.descriptionThis free journal suppl. entitled: Special Issue: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma Abstracts, 22 October 2015, Varese, Italy-
dc.descriptionPeer-reviewed Oral Presentation-
dc.description.abstractBACKGROUND: Non-anaplastic peripheral T-cell lymphomas (PTCL) are rare in the pediatric population and little is known about outcome and treatment options. OBJECTIVES: The present study is a joint, international, retrospective review of reported cases of PTCL in patients below 18 years, with focus on treatment options and outcome. Design/Methods: Only cases reviewed by national or international reference pathologists have been included. RESULTS: Until now, 122 patients diagnosed between 1995 and 2015 have been included in the study. The frequency of PTCL in the population-based reports (western Europe) was around 1%, which is lower than reported in older publications where Alk+ ALCL were included in this group. Patients were treated according to different treatment regimens, classified as B-cell type, T-cell type or other. pOS at 5 years for the group was at 54% and pEFS at 45%. 28 patients were reported to have a pre-existing disease and this group of patients had worse outcome with pOS at 5 years of 29%. PTCL NOS was the largest subtype, with 53 patients, followed by extranodal NK/T-cell lymphoma, nasal type (n = 21), hepatosplenic T-cell lymphoma (n = 16) and subcutaneous panniculitis-like T-cell lymphoma (n = 12). Patients with subcutaneous panniculitis-like T-cell lymphoma had a good outcome with a p OS at 5 years of 83% while patients with hepatosplenic T-cell lymphoma were reported with only pOS of only 16%. There was no clear difference in outcome between patients treated with a B-cell type or a T-cell type of treatment but in general outcome after CHOP/CHOEP appeared to be inferior. CONCLUSION: PTCL is a heterogeneous group of diseases where PTCL NOS is the largest subgroup. Pre -existing medical condition was reported in 25% of the cases and was associated with a poor treatment result. There is a clear need for disease-based treatment recommendation for this group of patients.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH-
dc.relation.ispartofBritish Journal of Haematology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleNon-anaplastic peripheral T-cell lymphoma in children and adolescents - International review-
dc.typeConference_Paper-
dc.identifier.emailChiang, A: chiangak@hku.hk-
dc.identifier.authorityChiang, A=rp00403-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/bjh.13753-
dc.identifier.hkuros256358-
dc.identifier.volume171-
dc.identifier.issuesuppl. S1-
dc.identifier.spage13, abstract no. 19-
dc.identifier.epage13, abstract no. 19-
dc.publisher.placeUnited Kingdom-

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