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Article: The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s

TitleThe rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s
Authors
KeywordsChina
CRF01_AE
HIV-1
Near full-length genome
Phylogenetic cluster
Risk population
Issue Date2013
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.com
Citation
Aids, 2013, v. 27 n. 11, p. 1793-1802 How to Cite?
AbstractObjectives: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. Methods: Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China. Results: We generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country. Conclusion: China's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B′ strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission.
Persistent Identifierhttp://hdl.handle.net/10722/221825
ISSN
2015 Impact Factor: 4.407
2015 SCImago Journal Rankings: 3.112
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeng, Y-
dc.contributor.authorHe, X-
dc.contributor.authorHsi, JH-
dc.contributor.authorLi, F-
dc.contributor.authorLi, X-
dc.contributor.authorWang, Q-
dc.contributor.authorRuan, Y-
dc.contributor.authorXing, H-
dc.contributor.authorLam, TY-
dc.contributor.authorPybus, OG-
dc.contributor.authorTakebe, Y-
dc.contributor.authorShao, Y-
dc.date.accessioned2015-12-10T03:29:48Z-
dc.date.available2015-12-10T03:29:48Z-
dc.date.issued2013-
dc.identifier.citationAids, 2013, v. 27 n. 11, p. 1793-1802-
dc.identifier.issn0269-9370-
dc.identifier.urihttp://hdl.handle.net/10722/221825-
dc.description.abstractObjectives: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. Methods: Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China. Results: We generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country. Conclusion: China's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B′ strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission.-
dc.languageeng-
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.AIDSonline.com-
dc.relation.ispartofAids-
dc.rightsThis is a non-final version of an article published in final form in Aids, 2013, v. 27 n. 11, p. 1793-1802-
dc.subjectChina-
dc.subjectCRF01_AE-
dc.subjectHIV-1-
dc.subjectNear full-length genome-
dc.subjectPhylogenetic cluster-
dc.subjectRisk population-
dc.titleThe rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s-
dc.typeArticle-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.authorityLam, TY=rp01733-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/QAD.0b013e328360db2d-
dc.identifier.pmcidPMC3819312-
dc.identifier.volume27-
dc.identifier.issue11-
dc.identifier.spage1793-
dc.identifier.epage1802-
dc.identifier.isiWOS:000326841200013-
dc.publisher.placeUnited States-

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