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Article: A study of the efficiency of pooling in haplotype estimation

TitleA study of the efficiency of pooling in haplotype estimation
Authors
KeywordsAlgorithms
Haplotypes
Issue Date2010
Citation
Bioinformatics (Oxford, England), 2010, v. 26, n. 20, p. 2556-2563 How to Cite?
AbstractIt has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when the number of loci increases.
Persistent Identifierhttp://hdl.handle.net/10722/221687
ISSN
2015 Impact Factor: 5.766
2015 SCImago Journal Rankings: 4.643
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKuk, AYC-
dc.contributor.authorXu, J-
dc.contributor.authorYang, Y-
dc.date.accessioned2015-12-04T15:29:07Z-
dc.date.available2015-12-04T15:29:07Z-
dc.date.issued2010-
dc.identifier.citationBioinformatics (Oxford, England), 2010, v. 26, n. 20, p. 2556-2563-
dc.identifier.issn1367-4803-
dc.identifier.urihttp://hdl.handle.net/10722/221687-
dc.description.abstractIt has been claimed in the literature that pooling DNA samples is efficient in estimating haplotype frequencies. There is, however, no theoretical justification based on calculation of statistical efficiency. In fact, the limited evidence given so far is based on simulation studies with small numbers of loci. With rapid advance in technology, it is of interest to see if pooling is still efficient when the number of loci increases.-
dc.languageeng-
dc.relation.ispartofBioinformatics (Oxford, England)-
dc.subjectAlgorithms-
dc.subjectHaplotypes-
dc.titleA study of the efficiency of pooling in haplotype estimation-
dc.typeArticle-
dc.identifier.emailXu, J: xujf@hku.hk-
dc.identifier.authorityXu, J=rp02086-
dc.identifier.doi10.1093/bioinformatics/btq492-
dc.identifier.pmid20801910-
dc.identifier.scopuseid_2-s2.0-77957768673-
dc.identifier.volume26-
dc.identifier.spage2556-
dc.identifier.epage2563-
dc.identifier.isiWOS:000282749700008-

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