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Conference Paper: Altered psychostimulant sensitivity in mice overexpressing epidermal growth factor

TitleAltered psychostimulant sensitivity in mice overexpressing epidermal growth factor
Authors
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), Kobe, Japan, 2-4 September 2010. In Neuroscience Research, 2010, v. 68 n. Suppl. 1, p. e420, abstract no. P3-o06 How to Cite?
AbstractEpidermal growth factor (EGF) and its structurally related proteins are involved in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. We have reported that EGF and EGF receptor abnormalities in both the brain tissues and peripheral blood of schizophrenic patients, which might be implicated in dopaminergic dysfunction of this disease. EGF overexpression in transgenic (Tg) mice displayed alterations in physical development, behavioral abnormalities in sensorimotor gating and prepulse inhibition of acoustic startle at the adult stage. In the present study, weinvestigated psychostimulant sensitivity of EGF Tg mice. At the adult stage, mice were challenged with cocaine (20 mg/kg, i.p. for 5days), and locomotor activity was examined (day1, 3, 5). EGF Tg mice enhanced behavioral responses to cocaine. Control mice gradually increased locomotor responses to cocaine during their daily injections, whereas EGF Tg mice required repeated injections and exhibited time delay in cocaine responses. Repeated administration of psychostimulant drugs, such as cocaine was induced behavioral sensitization in EGF Tg mice. In addition, the expression of monoamine transporter in the globus pallidus of EGF Tg mice altered compared to that of control animals. These results suggest that drug addiction might be implicated in dopaminergic neuron as monoamine transporter. Our findings indicate a potential link between EGF receptor activation and drug addiction.
Persistent Identifierhttp://hdl.handle.net/10722/221585
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorEda, T-
dc.contributor.authorMizuno, M-
dc.contributor.authorChan, SY-
dc.contributor.authorNawa, H-
dc.date.accessioned2015-11-30T03:39:51Z-
dc.date.available2015-11-30T03:39:51Z-
dc.date.issued2010-
dc.identifier.citationThe 33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010), Kobe, Japan, 2-4 September 2010. In Neuroscience Research, 2010, v. 68 n. Suppl. 1, p. e420, abstract no. P3-o06-
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/221585-
dc.description.abstractEpidermal growth factor (EGF) and its structurally related proteins are involved in the developmental regulation of various brain neurons, including midbrain dopaminergic neurons. We have reported that EGF and EGF receptor abnormalities in both the brain tissues and peripheral blood of schizophrenic patients, which might be implicated in dopaminergic dysfunction of this disease. EGF overexpression in transgenic (Tg) mice displayed alterations in physical development, behavioral abnormalities in sensorimotor gating and prepulse inhibition of acoustic startle at the adult stage. In the present study, weinvestigated psychostimulant sensitivity of EGF Tg mice. At the adult stage, mice were challenged with cocaine (20 mg/kg, i.p. for 5days), and locomotor activity was examined (day1, 3, 5). EGF Tg mice enhanced behavioral responses to cocaine. Control mice gradually increased locomotor responses to cocaine during their daily injections, whereas EGF Tg mice required repeated injections and exhibited time delay in cocaine responses. Repeated administration of psychostimulant drugs, such as cocaine was induced behavioral sensitization in EGF Tg mice. In addition, the expression of monoamine transporter in the globus pallidus of EGF Tg mice altered compared to that of control animals. These results suggest that drug addiction might be implicated in dopaminergic neuron as monoamine transporter. Our findings indicate a potential link between EGF receptor activation and drug addiction.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures-
dc.relation.ispartofNeuroscience Research-
dc.titleAltered psychostimulant sensitivity in mice overexpressing epidermal growth factor-
dc.typeConference_Paper-
dc.identifier.emailChan, SY: sychan@hkucc.hku.hk-
dc.identifier.authorityChan, SY=rp00356-
dc.identifier.doi10.1016/j.neures.2010.07.1863-
dc.identifier.hkuros256270-
dc.identifier.volume68-
dc.identifier.issueSuppl. 1-
dc.identifier.spagee420-
dc.identifier.epagee420-
dc.publisher.placeIreland-

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