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Article: Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions

TitleConduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
Authors
Issue Date2015
PublisherElsevier BV. The Journal's web site is located at http://www.ijcha-journal.com
Citation
International Journal of Cardiology: Heart & Vasculature, 2015, v. 9, p. 75-82 How to Cite?
AbstractVentricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes. © 2015 The Authors.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/221537
ISSN
2015 SCImago Journal Rankings: 0.218

 

DC FieldValueLanguage
dc.contributor.authorTse, G-
dc.contributor.authorYeo, JM-
dc.date.accessioned2015-11-30T03:32:57Z-
dc.date.available2015-11-30T03:32:57Z-
dc.date.issued2015-
dc.identifier.citationInternational Journal of Cardiology: Heart & Vasculature, 2015, v. 9, p. 75-82-
dc.identifier.issn2352-9067-
dc.identifier.urihttp://hdl.handle.net/10722/221537-
dc.descriptionOpen Access Journal-
dc.description.abstractVentricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes. © 2015 The Authors.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.ijcha-journal.com-
dc.relation.ispartofInternational Journal of Cardiology: Heart & Vasculature-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleConduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions-
dc.typeArticle-
dc.identifier.emailTse, G: tseg@hku.hk-
dc.identifier.authorityTse, G=rp02073-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ijcha.2015.10.003-
dc.identifier.scopuseid_2-s2.0-84946014380-
dc.identifier.hkuros256279-
dc.identifier.volume9-
dc.identifier.spage75-
dc.identifier.epage82-
dc.publisher.placeNetherlands-

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