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- Publisher Website: 10.1111/j.1365-2249.1991.tb05798.x
- Scopus: eid_2-s2.0-0025997724
- PMID: 1718638
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Article: Aberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally
Title | Aberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally |
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Authors | |
Keywords | B cells CD5+ plaque‐forming cells rheumatoid arthritis IgA nephropathy T‐regulation |
Issue Date | 1991 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI |
Citation | Clinical and Experimental Immunology, 1991, v. 86 n. 2, p. 212-218 How to Cite? |
Abstract | T-suppressor function and T-helper function in healthy adults, elderly patients with non-immune diseases, and patients with rheumatoid arthritis (RA) and IgA nephropathy (IgAN) were titrated by adding graded concentrations of CD8+ cells to autologous CD8-depleted peripheral blood mononuclear cells (PBMC), or CD4+ cells to CD8- 4- PBMC, respectively. Following culture with pokeweed mitogen (PWM), numbers of CD5+ and CD5- immunoglobulin-secreting cells were determined using a combination of rosetting with anti-CD5-coated Dynabeads and reverse haemolytic plaque formation (Jones, 1990). Of 11 RA patients studied, eight had slightly reduced suppressor activity for CD5+ and CD5- IgM-secreting cells, and three with active disease and high serum levels of C-reactive protein, could not suppress IgG, IgA or IgM secretion by either B subset. Helper activity for both CD5+ and CD5- B cells was slightly but significantly increased in RA patients. One of eight patients with IgAN could not suppress IgG, IgA or IgM production by CD5+ or CD5- B cells, and all IgAN patients required strikingly fewer CD4+ cells for PWM-induced activation of CD5+ and CD5- B cells than controls. It was concluded that in two immunologically mediated diseases in which some patients have raised numbers of circulating CD5+ B cells, aberrant T-regulation affects CD5+ and conventional CD5- B cells equally. |
Persistent Identifier | http://hdl.handle.net/10722/221534 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.114 |
PubMed Central ID |
DC Field | Value | Language |
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dc.contributor.author | Jones, BM | - |
dc.contributor.author | Cheng, IKP | - |
dc.contributor.author | Wong, RWS | - |
dc.date.accessioned | 2015-11-30T00:33:48Z | - |
dc.date.available | 2015-11-30T00:33:48Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Clinical and Experimental Immunology, 1991, v. 86 n. 2, p. 212-218 | - |
dc.identifier.issn | 0009-9104 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221534 | - |
dc.description.abstract | T-suppressor function and T-helper function in healthy adults, elderly patients with non-immune diseases, and patients with rheumatoid arthritis (RA) and IgA nephropathy (IgAN) were titrated by adding graded concentrations of CD8+ cells to autologous CD8-depleted peripheral blood mononuclear cells (PBMC), or CD4+ cells to CD8- 4- PBMC, respectively. Following culture with pokeweed mitogen (PWM), numbers of CD5+ and CD5- immunoglobulin-secreting cells were determined using a combination of rosetting with anti-CD5-coated Dynabeads and reverse haemolytic plaque formation (Jones, 1990). Of 11 RA patients studied, eight had slightly reduced suppressor activity for CD5+ and CD5- IgM-secreting cells, and three with active disease and high serum levels of C-reactive protein, could not suppress IgG, IgA or IgM secretion by either B subset. Helper activity for both CD5+ and CD5- B cells was slightly but significantly increased in RA patients. One of eight patients with IgAN could not suppress IgG, IgA or IgM production by CD5+ or CD5- B cells, and all IgAN patients required strikingly fewer CD4+ cells for PWM-induced activation of CD5+ and CD5- B cells than controls. It was concluded that in two immunologically mediated diseases in which some patients have raised numbers of circulating CD5+ B cells, aberrant T-regulation affects CD5+ and conventional CD5- B cells equally. | - |
dc.language | eng | - |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI | - |
dc.relation.ispartof | Clinical and Experimental Immunology | - |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject | B cells | - |
dc.subject | CD5+ | - |
dc.subject | plaque‐forming cells | - |
dc.subject | rheumatoid arthritis IgA nephropathy | - |
dc.subject | T‐regulation | - |
dc.subject.mesh | Arthritis, Rheumatoid - immunology | - |
dc.subject.mesh | B-Lymphocyte Subsets - immunology | - |
dc.subject.mesh | Glomerulonephritis, IGA - immunology | - |
dc.subject.mesh | T-Lymphocytes - immunology | - |
dc.subject.mesh | T-Lymphocytes, Helper-Inducer - immunology | - |
dc.title | Aberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/j.1365-2249.1991.tb05798.x | - |
dc.identifier.pmid | 1718638 | - |
dc.identifier.pmcid | PMC1554139 | - |
dc.identifier.scopus | eid_2-s2.0-0025997724 | - |
dc.identifier.hkuros | 140732 | - |
dc.identifier.volume | 86 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 212 | - |
dc.identifier.epage | 218 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0009-9104 | - |