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Article: Aberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally

TitleAberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally
Authors
Issue Date1991
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI
Citation
Clinical and Experimental Immunology, 1991, v. 86 n. 2, p. 212-218 How to Cite?
AbstractT-suppressor function and T-helper function in healthy adults, elderly patients with non-immune diseases, and patients with rheumatoid arthritis (RA) and IgA nephropathy (IgAN) were titrated by adding graded concentrations of CD8+ cells to autologous CD8-depleted peripheral blood mononuclear cells (PBMC), or CD4+ cells to CD8- 4- PBMC, respectively. Following culture with pokeweed mitogen (PWM), numbers of CD5+ and CD5- immunoglobulin-secreting cells were determined using a combination of rosetting with anti-CD5-coated Dynabeads and reverse haemolytic plaque formation (Jones, 1990). Of 11 RA patients studied, eight had slightly reduced suppressor activity for CD5+ and CD5- IgM-secreting cells, and three with active disease and high serum levels of C-reactive protein, could not suppress IgG, IgA or IgM secretion by either B subset. Helper activity for both CD5+ and CD5- B cells was slightly but significantly increased in RA patients. One of eight patients with IgAN could not suppress IgG, IgA or IgM production by CD5+ or CD5- B cells, and all IgAN patients required strikingly fewer CD4+ cells for PWM-induced activation of CD5+ and CD5- B cells than controls. It was concluded that in two immunologically mediated diseases in which some patients have raised numbers of circulating CD5+ B cells, aberrant T-regulation affects CD5+ and conventional CD5- B cells equally.
Persistent Identifierhttp://hdl.handle.net/10722/221534
ISSN
2015 Impact Factor: 3.148
2015 SCImago Journal Rankings: 1.369
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorJones, BM-
dc.contributor.authorCheng, IKP-
dc.contributor.authorWong, RWS-
dc.date.accessioned2015-11-30T00:33:48Z-
dc.date.available2015-11-30T00:33:48Z-
dc.date.issued1991-
dc.identifier.citationClinical and Experimental Immunology, 1991, v. 86 n. 2, p. 212-218-
dc.identifier.issn0009-9104-
dc.identifier.urihttp://hdl.handle.net/10722/221534-
dc.description.abstractT-suppressor function and T-helper function in healthy adults, elderly patients with non-immune diseases, and patients with rheumatoid arthritis (RA) and IgA nephropathy (IgAN) were titrated by adding graded concentrations of CD8+ cells to autologous CD8-depleted peripheral blood mononuclear cells (PBMC), or CD4+ cells to CD8- 4- PBMC, respectively. Following culture with pokeweed mitogen (PWM), numbers of CD5+ and CD5- immunoglobulin-secreting cells were determined using a combination of rosetting with anti-CD5-coated Dynabeads and reverse haemolytic plaque formation (Jones, 1990). Of 11 RA patients studied, eight had slightly reduced suppressor activity for CD5+ and CD5- IgM-secreting cells, and three with active disease and high serum levels of C-reactive protein, could not suppress IgG, IgA or IgM secretion by either B subset. Helper activity for both CD5+ and CD5- B cells was slightly but significantly increased in RA patients. One of eight patients with IgAN could not suppress IgG, IgA or IgM production by CD5+ or CD5- B cells, and all IgAN patients required strikingly fewer CD4+ cells for PWM-induced activation of CD5+ and CD5- B cells than controls. It was concluded that in two immunologically mediated diseases in which some patients have raised numbers of circulating CD5+ B cells, aberrant T-regulation affects CD5+ and conventional CD5- B cells equally.-
dc.languageeng-
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEI-
dc.relation.ispartofClinical and Experimental Immunology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshArthritis, Rheumatoid - immunology-
dc.subject.meshB-Lymphocyte Subsets - immunology-
dc.subject.meshGlomerulonephritis, IGA - immunology-
dc.subject.meshT-Lymphocytes - immunology-
dc.subject.meshT-Lymphocytes, Helper-Inducer - immunology-
dc.titleAberrant T-regulation in rheumatoid arthritis and IgA nephropathy affects CD5+ and CD5- B lymphocytes equally-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2249.1991.tb05798.x-
dc.identifier.pmid1718638-
dc.identifier.pmcidPMC1554139-
dc.identifier.hkuros140732-
dc.identifier.volume86-
dc.identifier.issue2-
dc.identifier.spage212-
dc.identifier.epage218-
dc.publisher.placeUnited Kingdom-

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