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postgraduate thesis: The role of vitamin D in type 2 diabetes risk : a retrospective study

TitleThe role of vitamin D in type 2 diabetes risk : a retrospective study
Authors
Issue Date2015
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Li, H. [李康泓]. (2015). The role of vitamin D in type 2 diabetes risk : a retrospective study. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5633800
AbstractBackground The incidence of Type 2 Diabetes Mellitus (T2DM) in the world rose drastically in the past ten years. Identification of risk factor of T2DM is important to predict and/or prevent the disease. Serum vitamin D level has been proposed as a protective factor against T2DM. However, the majority of the evidences were obtained in population from Western countries. The objective of this study is to examine the association of serum vitamin D level with T2DM in Hong Kong. Methods This was a retrospective analysis of 1417 participants of the Hong Kong Osteoporosis Study,1157 participants of them were analyzed (Figure 4). The diabetes status at baseline was ascertained from a structured questionnaire, whereas the incident diabetes was ascertained using the electronic medical record (EMR): Clinical Data Analysis and Reporting System (CDARS) of the Hong Kong Hospital Authority. The relationship between vitamin D and T2DM was evaluated using multivariable binary logistic regression and Cox proportional hazard regression. Subgroup analysis was also performed by vitamin D quartile, sex, BMI status, vitamin D insufficiency status and vitamin D deficiency status. Results The median follow-up of the study participants was 10.7 years. In binary logistic regression, serum vitamin D level was inversely associated with T2DM in fully adjusted model inall studied participants. In vitamin D insufficient subgroup analysis, serum vitamin D level was inversely associated with T2DM in crude model and fully adjusted model in vitamin D sufficiency subgroup. In Cox proportional hazard ratio, serum vitamin D level was associated with incident T2DM in the highest vitamin D quartile. However, the result became insignificant after further adjustment. Conclusion Inconsistent results were observed between serum vitamin D level and T2DM. Thus, future study should focus on people with vitamin D sufficiency and it is required to re-examine the findings. The discrepancy between findings from the Cox proportional hazard regression and binary logistic regression could be due to the fact that serum vitamin D is a marker of the presence of T2DM, rather than a predictor; or the time of T2DM ascertainment was not accurate. Future study in other Chinese population is required to provide more information on the role of vitamin D in T2DM.
DegreeMaster of Medical Sciences
SubjectNon-insulin-dependent diabetes - Risk factors
Vitamin D
Dept/ProgramPharmacology and Pharmacy
Persistent Identifierhttp://hdl.handle.net/10722/221480

 

DC FieldValueLanguage
dc.contributor.authorLi, Hong-wang-
dc.contributor.author李康泓-
dc.date.accessioned2015-11-26T23:36:48Z-
dc.date.available2015-11-26T23:36:48Z-
dc.date.issued2015-
dc.identifier.citationLi, H. [李康泓]. (2015). The role of vitamin D in type 2 diabetes risk : a retrospective study. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5633800-
dc.identifier.urihttp://hdl.handle.net/10722/221480-
dc.description.abstractBackground The incidence of Type 2 Diabetes Mellitus (T2DM) in the world rose drastically in the past ten years. Identification of risk factor of T2DM is important to predict and/or prevent the disease. Serum vitamin D level has been proposed as a protective factor against T2DM. However, the majority of the evidences were obtained in population from Western countries. The objective of this study is to examine the association of serum vitamin D level with T2DM in Hong Kong. Methods This was a retrospective analysis of 1417 participants of the Hong Kong Osteoporosis Study,1157 participants of them were analyzed (Figure 4). The diabetes status at baseline was ascertained from a structured questionnaire, whereas the incident diabetes was ascertained using the electronic medical record (EMR): Clinical Data Analysis and Reporting System (CDARS) of the Hong Kong Hospital Authority. The relationship between vitamin D and T2DM was evaluated using multivariable binary logistic regression and Cox proportional hazard regression. Subgroup analysis was also performed by vitamin D quartile, sex, BMI status, vitamin D insufficiency status and vitamin D deficiency status. Results The median follow-up of the study participants was 10.7 years. In binary logistic regression, serum vitamin D level was inversely associated with T2DM in fully adjusted model inall studied participants. In vitamin D insufficient subgroup analysis, serum vitamin D level was inversely associated with T2DM in crude model and fully adjusted model in vitamin D sufficiency subgroup. In Cox proportional hazard ratio, serum vitamin D level was associated with incident T2DM in the highest vitamin D quartile. However, the result became insignificant after further adjustment. Conclusion Inconsistent results were observed between serum vitamin D level and T2DM. Thus, future study should focus on people with vitamin D sufficiency and it is required to re-examine the findings. The discrepancy between findings from the Cox proportional hazard regression and binary logistic regression could be due to the fact that serum vitamin D is a marker of the presence of T2DM, rather than a predictor; or the time of T2DM ascertainment was not accurate. Future study in other Chinese population is required to provide more information on the role of vitamin D in T2DM.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.lcshNon-insulin-dependent diabetes - Risk factors-
dc.subject.lcshVitamin D-
dc.titleThe role of vitamin D in type 2 diabetes risk : a retrospective study-
dc.typePG_Thesis-
dc.identifier.hkulb5633800-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplinePharmacology and Pharmacy-
dc.description.naturepublished_or_final_version-

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