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postgraduate thesis: Glutamatergic transmission in the neonatal vestibular nucleus contributes to developmental acquisition of spatial navigation

TitleGlutamatergic transmission in the neonatal vestibular nucleus contributes to developmental acquisition of spatial navigation
Authors
Issue Date2015
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Lee, K. J. [李嘉康]. (2015). Glutamatergic transmission in the neonatal vestibular nucleus contributes to developmental acquisition of spatial navigation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5632481
AbstractSpatial navigation is an instinct skill in most creatures on this plantlet. The ability of spatial navigation is related to the sensory system, which is located inside the vestibular system, which is also a place for processing learning and memory as well. Those actions and behaviors are mediated by glutamate receptors, two types of ionotropic glutamate receptors, N-methyl-D-aspartate (NMDA) receptor and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor are abundantly found in the vestibular nucleus (VN). By activating the glutamatergic transmission, a short-term, fast stimulation will occur in between the synapse and leads to a potent, slow signals stimulation, which results in brain synaptic plasticity, as learning and memory being involved. Improper development of VN during critical period may lead to an impairment of behavior on spatial navigation and motor learning. In this study, the contribution of developing glutamatergic transmission during neonatal stage to the motor learning of spatial navigation will be investigated. AMPA receptors and NMDA receptors antagonists were implanted in the VN on postnatal day 1 (P1) and dead reckoning test, which is a behavior assessment was conducted on P60. Two glutamate receptors antagonists, [5R,10S]-[+]-5-methyl-10,11- dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (MK-801) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) was used to block NMDA receptors and AMPA receptors respectively. The result of this study shown that rats with CNQX-treated expressed significant spatial navigation impairment during dead reckoning test. Under new location probe test, deflect of motor learning and memory behavior was observed under rats with CNQX-treated. In other words, the afferent of CNQX to the VN demonstrated the importance of development of AMPA receptor during neonatal stage to motor learning of spatial navigation. This finding also suggested deflects of AMPA receptors may also lead to difficulties of reorganization between allothetic and idiothetic cues during memorizing and motor learning on spatial navigation. The importance of neonatal development of glutamatergic transmission, especially the AMPA-mediated signal cannot be neglected in acquisition of performing spatial navigation and learning behavior.
DegreeMaster of Medical Sciences
SubjectVestibular nuclei
Glutamic acid - Receptors
Space perception
Dept/ProgramBiomedical Sciences
Persistent Identifierhttp://hdl.handle.net/10722/221479

 

DC FieldValueLanguage
dc.contributor.authorLee, Ka-hong, John-
dc.contributor.author李嘉康-
dc.date.accessioned2015-11-26T23:36:46Z-
dc.date.available2015-11-26T23:36:46Z-
dc.date.issued2015-
dc.identifier.citationLee, K. J. [李嘉康]. (2015). Glutamatergic transmission in the neonatal vestibular nucleus contributes to developmental acquisition of spatial navigation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5632481-
dc.identifier.urihttp://hdl.handle.net/10722/221479-
dc.description.abstractSpatial navigation is an instinct skill in most creatures on this plantlet. The ability of spatial navigation is related to the sensory system, which is located inside the vestibular system, which is also a place for processing learning and memory as well. Those actions and behaviors are mediated by glutamate receptors, two types of ionotropic glutamate receptors, N-methyl-D-aspartate (NMDA) receptor and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor are abundantly found in the vestibular nucleus (VN). By activating the glutamatergic transmission, a short-term, fast stimulation will occur in between the synapse and leads to a potent, slow signals stimulation, which results in brain synaptic plasticity, as learning and memory being involved. Improper development of VN during critical period may lead to an impairment of behavior on spatial navigation and motor learning. In this study, the contribution of developing glutamatergic transmission during neonatal stage to the motor learning of spatial navigation will be investigated. AMPA receptors and NMDA receptors antagonists were implanted in the VN on postnatal day 1 (P1) and dead reckoning test, which is a behavior assessment was conducted on P60. Two glutamate receptors antagonists, [5R,10S]-[+]-5-methyl-10,11- dihydro-5H- dibenzo[a,d]cyclohepten-5,10-imine (MK-801) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) was used to block NMDA receptors and AMPA receptors respectively. The result of this study shown that rats with CNQX-treated expressed significant spatial navigation impairment during dead reckoning test. Under new location probe test, deflect of motor learning and memory behavior was observed under rats with CNQX-treated. In other words, the afferent of CNQX to the VN demonstrated the importance of development of AMPA receptor during neonatal stage to motor learning of spatial navigation. This finding also suggested deflects of AMPA receptors may also lead to difficulties of reorganization between allothetic and idiothetic cues during memorizing and motor learning on spatial navigation. The importance of neonatal development of glutamatergic transmission, especially the AMPA-mediated signal cannot be neglected in acquisition of performing spatial navigation and learning behavior.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.subject.lcshVestibular nuclei-
dc.subject.lcshGlutamic acid - Receptors-
dc.subject.lcshSpace perception-
dc.titleGlutamatergic transmission in the neonatal vestibular nucleus contributes to developmental acquisition of spatial navigation-
dc.typePG_Thesis-
dc.identifier.hkulb5632481-
dc.description.thesisnameMaster of Medical Sciences-
dc.description.thesislevelMaster-
dc.description.thesisdisciplineBiomedical Sciences-
dc.description.naturepublished_or_final_version-

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