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Article: Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

TitleMeta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Authors
Issue Date2013
Citation
Nature Genetics, 2013, v. 45, n. 8, p. 902-906 How to Cite?
AbstractAllergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. © 2013 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/221348
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBønnelykke, Klaus-
dc.contributor.authorMatheson, Melanie C.-
dc.contributor.authorPers, Tune H.-
dc.contributor.authorGranell, Raquel-
dc.contributor.authorStrachan, David P.-
dc.contributor.authorAlves, Alexessander Couto-
dc.contributor.authorLinneberg, Allan-
dc.contributor.authorCurtin, John A.-
dc.contributor.authorWarrington, Nicole M.-
dc.contributor.authorStandl, Marie-
dc.contributor.authorKerkhof, Marjan-
dc.contributor.authorJonsdottir, Ingileif-
dc.contributor.authorBukvic, Blazenka K.-
dc.contributor.authorKaakinen, Marika-
dc.contributor.authorSleimann, Patrick-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorSchramm, Katharina-
dc.contributor.authorBaltic, Svetlana-
dc.contributor.authorMøller, Eskil Kreiner-
dc.contributor.authorSimpson, Angela-
dc.contributor.authorSt Pourcain, Beate-
dc.contributor.authorCoin, Lachlan-
dc.contributor.authorHui, Jennie-
dc.contributor.authorWalters, Eugene H.-
dc.contributor.authorTiesler, Carla M T-
dc.contributor.authorDuffy, David L.-
dc.contributor.authorJones, Graham-
dc.contributor.authorRing, Susan M.-
dc.contributor.authorMcArdle, Wendy L.-
dc.contributor.authorPrice, Loren-
dc.contributor.authorRobertson, Colin F.-
dc.contributor.authorPekkanen, Juha-
dc.contributor.authorTang, Clara S.-
dc.contributor.authorThiering, Elisabeth-
dc.contributor.authorMontgomery, Grant W.-
dc.contributor.authorHartikainen, Anna Liisa-
dc.contributor.authorDharmage, Shyamali C.-
dc.contributor.authorHusemoen, Lise L.-
dc.contributor.authorHerder, Christian-
dc.contributor.authorKemp, John P.-
dc.contributor.authorElliot, Paul-
dc.contributor.authorJames, Alan-
dc.contributor.authorWaldenberger, Melanie-
dc.contributor.authorAbramson, Michael J.-
dc.contributor.authorFairfax, Benjamin P.-
dc.contributor.authorKnight, C. Julian-
dc.contributor.authorGupta, Ramneek-
dc.contributor.authorThompson, Philip J.-
dc.contributor.authorHolt, Patrick-
dc.contributor.authorSly, Peter-
dc.contributor.authorHirschhorn, Joel N.-
dc.contributor.authorBlekic, Mario-
dc.contributor.authorWeidinger, Stephan-
dc.contributor.authorHakonarsson, Hakon-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorHeinrich, Joachim-
dc.contributor.authorPostma, Dirkje S.-
dc.contributor.authorCustovic, Adnan-
dc.contributor.authorPennell, Craig E.-
dc.contributor.authorJarvelin, Marjo Riitta-
dc.contributor.authorKoppelman, Gerard H.-
dc.contributor.authorTimpson, Nicholas-
dc.contributor.authorFerreira, Manuel A.-
dc.contributor.authorBisgaard, Hans-
dc.contributor.authorHenderson, A. John-
dc.date.accessioned2015-11-18T06:09:04Z-
dc.date.available2015-11-18T06:09:04Z-
dc.date.issued2013-
dc.identifier.citationNature Genetics, 2013, v. 45, n. 8, p. 902-906-
dc.identifier.issn1061-4036-
dc.identifier.urihttp://hdl.handle.net/10722/221348-
dc.description.abstractAllergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. © 2013 Nature America, Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofNature Genetics-
dc.titleMeta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.2694-
dc.identifier.pmid23817571-
dc.identifier.scopuseid_2-s2.0-84881030765-
dc.identifier.hkuros234030-
dc.identifier.volume45-
dc.identifier.issue8-
dc.identifier.spage902-
dc.identifier.epage906-
dc.identifier.eissn1546-1718-
dc.identifier.isiWOS:000322374900013-
dc.identifier.f1000718039860-

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