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Article: Effects of MLC601 on early vascular events in patients after stroke: The CHIMES study

TitleEffects of MLC601 on early vascular events in patients after stroke: The CHIMES study
Authors
KeywordsSecondary prevention
Stroke
Vascular diseases
Clinical trial
Neuroaid
Issue Date2013
Citation
Stroke, 2013, v. 44, n. 12, p. 3580-3583 How to Cite?
AbstractBACKGROUND AND PURPOSE - Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset. METHODS - Post hoc analysis was performed on data from subjects included in the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study, a randomized, placebo-controlled, double-blinded trial that compared MLC601 with placebo in 1099 subjects with ischemic stroke of intermediate severity in the preceding 72 hours. Early vascular events were defined as a composite of recurrent stroke, acute coronary syndrome, and vascular death occurring within 3 months of stroke onset. RESULTS - The frequency of early vascular events during the 3-month follow-up was significantly less in the MLC601 group than in the placebo group (16 [2.9%] versus 31 events [5.6%]; risk difference=-2.7%; 95% confidence interval, -5.1% to -0.4%; P=0.025) without an increase in nonvascular deaths. Kaplan-Meier survival analysis showed a difference in the risk of vascular outcomes between the 2 groups as early as the first month after stroke (Log-rank P=0.024; hazard ratio, 0.51; 95% confidence interval, 0.28-0.93). CONCLUSIONS - Treatment with MLC601 was associated with reduced early vascular events among subjects in the CHIMES study. The mechanisms for this effect require further study. © 2013 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/220883
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671

 

DC FieldValueLanguage
dc.contributor.authorChen, Christopher L H-
dc.contributor.authorVenketasubramanian, Narayanaswamy-
dc.contributor.authorLee, Chun Fan-
dc.contributor.authorWong, K. S Lawrence-
dc.contributor.authorBousser, Marie Germaine-
dc.contributor.authorNavarro, Jose C.-
dc.contributor.authorGan, Herminigildo H.-
dc.contributor.authorLao, Annabelle Y.-
dc.contributor.authorBaroque, Alejandro C.-
dc.contributor.authorLokin, Johnny-
dc.contributor.authorHiyadan, John Harold B-
dc.contributor.authorSarfati, Ma Socorro-
dc.contributor.authorFangonillo, Randolph John-
dc.contributor.authorAmbasing, Neil-
dc.contributor.authorChua, Carlos L.-
dc.contributor.authorSan Jose, Ma Cristina-
dc.contributor.authorAdvincula, Joel M.-
dc.contributor.authorBerame, Eli John-
dc.contributor.authorCanete, Maria Teresa-
dc.contributor.authorYoung, Sherry H Y-
dc.contributor.authorMamauag, Marlie Jane-
dc.contributor.authorTay, San San-
dc.contributor.authorPande, Shrikant-
dc.contributor.authorThirugnanam, Umapathi-
dc.contributor.authorSingh, Rajinder-
dc.contributor.authorChang, Hui Meng-
dc.contributor.authorDe Silva, Deidre Anne-
dc.contributor.authorChan, Bernard P L-
dc.contributor.authorSharma, Vijay-
dc.contributor.authorLuen, Teoh Hock-
dc.contributor.authorPoungvarin, Niphon-
dc.contributor.authorMuengtaweepongsa, Sombat-
dc.contributor.authorTowanabut, Somchai-
dc.contributor.authorSuwanwela, Nijasri C.-
dc.contributor.authorChotickanuchit, Songkram-
dc.contributor.authorChankrachang, Siwaporn-
dc.contributor.authorNitinun, Samart-
dc.contributor.authorDe Silva, H. Asita-
dc.contributor.authorRanawake, Udaya-
dc.contributor.authorWijekoon, Nirmala-
dc.contributor.authorEow, Gaik Bee-
dc.date.accessioned2015-10-22T09:04:42Z-
dc.date.available2015-10-22T09:04:42Z-
dc.date.issued2013-
dc.identifier.citationStroke, 2013, v. 44, n. 12, p. 3580-3583-
dc.identifier.issn0039-2499-
dc.identifier.urihttp://hdl.handle.net/10722/220883-
dc.description.abstractBACKGROUND AND PURPOSE - Early vascular events are an important cause of morbidity and mortality in the first 3 months after a stroke. We aimed to investigate the effects of MLC601 on the occurrence of early vascular events within 3 months of stroke onset. METHODS - Post hoc analysis was performed on data from subjects included in the CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES) study, a randomized, placebo-controlled, double-blinded trial that compared MLC601 with placebo in 1099 subjects with ischemic stroke of intermediate severity in the preceding 72 hours. Early vascular events were defined as a composite of recurrent stroke, acute coronary syndrome, and vascular death occurring within 3 months of stroke onset. RESULTS - The frequency of early vascular events during the 3-month follow-up was significantly less in the MLC601 group than in the placebo group (16 [2.9%] versus 31 events [5.6%]; risk difference=-2.7%; 95% confidence interval, -5.1% to -0.4%; P=0.025) without an increase in nonvascular deaths. Kaplan-Meier survival analysis showed a difference in the risk of vascular outcomes between the 2 groups as early as the first month after stroke (Log-rank P=0.024; hazard ratio, 0.51; 95% confidence interval, 0.28-0.93). CONCLUSIONS - Treatment with MLC601 was associated with reduced early vascular events among subjects in the CHIMES study. The mechanisms for this effect require further study. © 2013 American Heart Association, Inc.-
dc.languageeng-
dc.relation.ispartofStroke-
dc.subjectSecondary prevention-
dc.subjectStroke-
dc.subjectVascular diseases-
dc.subjectClinical trial-
dc.subjectNeuroaid-
dc.titleEffects of MLC601 on early vascular events in patients after stroke: The CHIMES study-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1161/STROKEAHA.113.003226-
dc.identifier.pmid24135924-
dc.identifier.scopuseid_2-s2.0-84889251989-
dc.identifier.volume44-
dc.identifier.issue12-
dc.identifier.spage3580-
dc.identifier.epage3583-
dc.identifier.eissn1524-4628-

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