File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Development Profile Of Neuron-Specific Enolase In Human Gut And Its Implications In Hirschsprung's Disease

TitleDevelopment Profile Of Neuron-Specific Enolase In Human Gut And Its Implications In Hirschsprung's Disease
Authors
Issue Date1986
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 1986, v. 90 n. 6, p. 1901-1906 How to Cite?
AbstractThe Most Widely Held View On The Pathogenesis Of Hirschsprung's Disease As An Arrest Of Neuroblast Migration In The Gut Was Based On The Hypothesis Of A Single Craniocaudal Gradient Of Development Of Enteric Neurons. Recent Experimental Studies In Animals, However, Have Revived A Contradictory Hypothesis Of A Dual Gradient Of Neuronal Development; Such Data Are Not Available In Humans. To Test These Hypotheses In Humans, We Studied The Pylorus, Ileum, And Colon Of 28 Fetuses With Gestational Ages Of 9-21 Wk, Using Immunohistochemical Localization Of Neuron-Specific Enolase, A Specific Neuronal Marker Indicative Of Differentiation. Development Of The Enteric Nervous System Was Shown To Be Most Advanced In The Pylorus, Less So In The Colon, And Least So In The Ileum. The Findings Support The Hypothesis Of A Dual Gradient Of Neuronal Development Proceeding From Both Ends Of The Middle Of The Gut In Midtrimester Human Fetuses And Suggest That The Pathogenesis Of Hirschsprung's Disease Needs To Be Reconsidered.
Persistent Identifierhttp://hdl.handle.net/10722/220834
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.contributor.authorLister, Jen_US
dc.date.accessioned2015-10-19T07:22:00Z-
dc.date.available2015-10-19T07:22:00Z-
dc.date.issued1986-
dc.identifier.citationGastroenterology, 1986, v. 90 n. 6, p. 1901-1906en_US
dc.identifier.issn0016-5085-
dc.identifier.urihttp://hdl.handle.net/10722/220834-
dc.description.abstractThe Most Widely Held View On The Pathogenesis Of Hirschsprung's Disease As An Arrest Of Neuroblast Migration In The Gut Was Based On The Hypothesis Of A Single Craniocaudal Gradient Of Development Of Enteric Neurons. Recent Experimental Studies In Animals, However, Have Revived A Contradictory Hypothesis Of A Dual Gradient Of Neuronal Development; Such Data Are Not Available In Humans. To Test These Hypotheses In Humans, We Studied The Pylorus, Ileum, And Colon Of 28 Fetuses With Gestational Ages Of 9-21 Wk, Using Immunohistochemical Localization Of Neuron-Specific Enolase, A Specific Neuronal Marker Indicative Of Differentiation. Development Of The Enteric Nervous System Was Shown To Be Most Advanced In The Pylorus, Less So In The Colon, And Least So In The Ileum. The Findings Support The Hypothesis Of A Dual Gradient Of Neuronal Development Proceeding From Both Ends Of The Middle Of The Gut In Midtrimester Human Fetuses And Suggest That The Pathogenesis Of Hirschsprung's Disease Needs To Be Reconsidered.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_US
dc.relation.ispartofGastroenterologyen_US
dc.titleDevelopment Profile Of Neuron-Specific Enolase In Human Gut And Its Implications In Hirschsprung's Diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3516786-
dc.identifier.scopuseid_2-s2.0-0022461866-
dc.identifier.volume90-
dc.identifier.issue6-
dc.identifier.spage1901-
dc.identifier.epage1906-
dc.identifier.isiWOS:A1986C312700011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats