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Article: Serum Pepsinogen I In Childhood Duodenal Ulcer

TitleSerum Pepsinogen I In Childhood Duodenal Ulcer
Authors
Issue Date1987
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.org
Citation
Journal Of Pediatric Gastroenterology And Nutrition, 1987, v. 6 n. 6, p. 904-907 How to Cite?
AbstractTo Delineate Possible Genetic Factors Involved In The Pathogenesis Of Childhood Duodenal Ulcer (Du), Serum Pepsinogen I Concentrations Were Measured In 14 Patients And Their Parents. Sixty-Five Normal Subjects Were Simultaneously Studied To Determine Normal Values In Relation To Age. Hyperpepsinogenemia Occurred In Six Of 14 Patients And 13 Of 28 Parents. Hyperpepsinogenemic Patients Invariably Had Hyperpepsinogenemic Parents, Four Of Six Having Both Parents Affected. Hyperpepsinogenemic Parents (10 Of 13) Usually But Not Invariably Gave Birth To Hyperpepsinogenemic Patients. Most Hyperpepsinogenemic Parents (11 Of 13) Were Asymptomatic. Our Findings Suggest A Genetic Basis (Hyperpepsinogenemia) For The Predisposition To Childhood Du In Nearly Half The Patient Population, The Inheritance Being Likely To Be Autosomal Dominant With Incomplete Penetrance. In Addition, The Existence Of Normopepsinogenemic Families Suggests That Childhood Du Is A Heterogeneous Entity And Not A Single Disease. A High Familial Incidence Of Du Is Also Present In The Normopepsinogenemic Subgroup (Four Of Eight) But Whether Genetic Factors Or Socioenvironmental Factors Are Responsible Here Will Require Elucidation From Studies With Other Markers.
Persistent Identifierhttp://hdl.handle.net/10722/220821
ISSN
2015 Impact Factor: 2.4
2015 SCImago Journal Rankings: 1.227
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.date.accessioned2015-10-19T04:23:36Z-
dc.date.available2015-10-19T04:23:36Z-
dc.date.issued1987-
dc.identifier.citationJournal Of Pediatric Gastroenterology And Nutrition, 1987, v. 6 n. 6, p. 904-907en_US
dc.identifier.issn0277-2116-
dc.identifier.urihttp://hdl.handle.net/10722/220821-
dc.description.abstractTo Delineate Possible Genetic Factors Involved In The Pathogenesis Of Childhood Duodenal Ulcer (Du), Serum Pepsinogen I Concentrations Were Measured In 14 Patients And Their Parents. Sixty-Five Normal Subjects Were Simultaneously Studied To Determine Normal Values In Relation To Age. Hyperpepsinogenemia Occurred In Six Of 14 Patients And 13 Of 28 Parents. Hyperpepsinogenemic Patients Invariably Had Hyperpepsinogenemic Parents, Four Of Six Having Both Parents Affected. Hyperpepsinogenemic Parents (10 Of 13) Usually But Not Invariably Gave Birth To Hyperpepsinogenemic Patients. Most Hyperpepsinogenemic Parents (11 Of 13) Were Asymptomatic. Our Findings Suggest A Genetic Basis (Hyperpepsinogenemia) For The Predisposition To Childhood Du In Nearly Half The Patient Population, The Inheritance Being Likely To Be Autosomal Dominant With Incomplete Penetrance. In Addition, The Existence Of Normopepsinogenemic Families Suggests That Childhood Du Is A Heterogeneous Entity And Not A Single Disease. A High Familial Incidence Of Du Is Also Present In The Normopepsinogenemic Subgroup (Four Of Eight) But Whether Genetic Factors Or Socioenvironmental Factors Are Responsible Here Will Require Elucidation From Studies With Other Markers.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.orgen_US
dc.relation.ispartofJournal Of Pediatric Gastroenterology And Nutritionen_US
dc.titleSerum Pepsinogen I In Childhood Duodenal Ulceren_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3681576-
dc.identifier.scopuseid_2-s2.0-0023603511-
dc.identifier.volume6-
dc.identifier.issue6-
dc.identifier.spage904-
dc.identifier.epage907-
dc.identifier.isiWOS:A1987K654700014-

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