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Article: The Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Children

TitleThe Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Children
Authors
Issue Date1989
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.org
Citation
Journal Of Pediatric Gastroenterology And Nutrition, 1989, v. 8 n. 1, p. 41-46 How to Cite?
AbstractWe Report Our 20 Years' Experience On The Management Of 78 Children With Primary Chronic Peptic Ulcer, Giving Special Emphasis To The Recent 32 Patients (29 Duodenal Ulcer, 3 Gastric Ulcer) Who Received H2-Antagonist Therapy Guided By Endoscopic Surveillance. The Most Striking Observation Was The Marked Decrease In The Incidence Of 'Failed Medical Treatment Necessitating Surgery' From 34.8% (16/46) In The Pre-H2-Antagonist Era To 3.1% (1/32) In The H2-Antagonist Era. H2 Antagonist Was Uniformly Well Tolerated And Without Side-Effects. In 29 Patients With Duodenal Ulcer, A 6-Week Therapeutic Course Resulted In Complete Ulcer Healing In 22 (75.9%). Further Therapeutic Courses Resulted In Complete Ulcer Healing In Four Additional Patients (13.8%). There Was Only Partial Ulcer Healing In Two Patients (6.9%) And Non-Healing In One Patient (3.49%). There Were 11 Episodes Of Recurrence In Nine Patients (Symptomatic 5, Asymptomatic 6). Recurrence Was More Frequent When Nocturnal-Dose Maintenance Was Not Given (8/11 Recurrences). All Recurences Responded Satisfactorily To Further H2-Antagonist Therapy. Patients With Gastric Ulcer Responded Even More Favorably, All Three Healing Completely With A Single Therapeutic Course And Not Requiring Maintenance Therapy. We Conclude That H2-Antagonist Is Safe And Highly Effective For Healing Peptic Ulcer In Children. For Duodenal Ulcer, Maintenance Therapy Ensures A Satisfactory Remission Rate.
Persistent Identifierhttp://hdl.handle.net/10722/220813
ISSN
2015 Impact Factor: 2.4
2015 SCImago Journal Rankings: 1.227
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.contributor.authorSaing, Hen_US
dc.date.accessioned2015-10-19T04:08:39Z-
dc.date.available2015-10-19T04:08:39Z-
dc.date.issued1989-
dc.identifier.citationJournal Of Pediatric Gastroenterology And Nutrition, 1989, v. 8 n. 1, p. 41-46en_US
dc.identifier.issn0277-2116-
dc.identifier.urihttp://hdl.handle.net/10722/220813-
dc.description.abstractWe Report Our 20 Years' Experience On The Management Of 78 Children With Primary Chronic Peptic Ulcer, Giving Special Emphasis To The Recent 32 Patients (29 Duodenal Ulcer, 3 Gastric Ulcer) Who Received H2-Antagonist Therapy Guided By Endoscopic Surveillance. The Most Striking Observation Was The Marked Decrease In The Incidence Of 'Failed Medical Treatment Necessitating Surgery' From 34.8% (16/46) In The Pre-H2-Antagonist Era To 3.1% (1/32) In The H2-Antagonist Era. H2 Antagonist Was Uniformly Well Tolerated And Without Side-Effects. In 29 Patients With Duodenal Ulcer, A 6-Week Therapeutic Course Resulted In Complete Ulcer Healing In 22 (75.9%). Further Therapeutic Courses Resulted In Complete Ulcer Healing In Four Additional Patients (13.8%). There Was Only Partial Ulcer Healing In Two Patients (6.9%) And Non-Healing In One Patient (3.49%). There Were 11 Episodes Of Recurrence In Nine Patients (Symptomatic 5, Asymptomatic 6). Recurrence Was More Frequent When Nocturnal-Dose Maintenance Was Not Given (8/11 Recurrences). All Recurences Responded Satisfactorily To Further H2-Antagonist Therapy. Patients With Gastric Ulcer Responded Even More Favorably, All Three Healing Completely With A Single Therapeutic Course And Not Requiring Maintenance Therapy. We Conclude That H2-Antagonist Is Safe And Highly Effective For Healing Peptic Ulcer In Children. For Duodenal Ulcer, Maintenance Therapy Ensures A Satisfactory Remission Rate.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jpgn.orgen_US
dc.relation.ispartofJournal Of Pediatric Gastroenterology And Nutritionen_US
dc.titleThe Use Of H2-Receptor Antagonist In The Treatment Of Peptic Ulcer Disease In Childrenen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2567346-
dc.identifier.scopuseid_2-s2.0-0024478263-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.spage41-
dc.identifier.epage46-
dc.identifier.isiWOS:A1989T010800009-

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