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Article: An Immunohistochemical Study Of Neuronal Microtubule-Associated Proteins In Hirschsprung's Disease

TitleAn Immunohistochemical Study Of Neuronal Microtubule-Associated Proteins In Hirschsprung's Disease
Authors
Issue Date1993
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1993, v. 24 n. 4, p. 424-431 How to Cite?
AbstractNeuronal Microtubule-Associated Proteins (Maps) Are Important Components Of Neurons And Are Believed To Regulate Neuronal Function And Development By Controlling The Assembly Of Microtubules And The Interaction Of Microtubules With Other Cytoplasmic Organelles. We Studied The Immunohistochemical Localization Of Maps 1, 2, 5, And Tau In The Intestinal Tissues Of Five Patients With Hirschsprung's Disease And In Five Normal Controls Using Monoclonal Antibodies. Microtubule-Associated Proteins 5 And Tau Proved To Be Excellent Enteric Neuronal Markers; They Were Specifically Located In The Nerve Cell Bodies And Processes Of Normal Intestine As Well As In The Abnormal Hypertrophied Nerve Fibers Of Aganglionic Colon. Fine Fibrillar Structures In The Neuroplasm Were Revealed In Greater Detail Than Were Those Obtained From Studies With Conventional Markers, Including Neuron-Specific Enolase, S-100 Protein, And Neurofilament Protein. A Slight Reduction Of Maps 5 And Tau Immunoreactivity Was Observed In The Aganglionic Colon Compared With Normal Colon. Microtubule-Associated Proteins 1 And 2 Were Absent From The Nerve Fibers In Both Normal And Aganglionic Colon. This Study Suggests That Immunostaining For Maps 5 And Tau May Be Superior To Other Immunohistochemical Methods For Diagnosing Hirschsprung's Disease; However, In View Of Its Limited Retrospective Nature These Findings Need To Be Corroborated By A Large Prospective Evaluation.
Persistent Identifierhttp://hdl.handle.net/10722/220793
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, PKHen_US
dc.contributor.authorOwen, Gen_US
dc.date.accessioned2015-10-19T03:47:20Z-
dc.date.available2015-10-19T03:47:20Z-
dc.date.issued1993-
dc.identifier.citationHuman Pathology, 1993, v. 24 n. 4, p. 424-431en_US
dc.identifier.issn0046-8177-
dc.identifier.urihttp://hdl.handle.net/10722/220793-
dc.description.abstractNeuronal Microtubule-Associated Proteins (Maps) Are Important Components Of Neurons And Are Believed To Regulate Neuronal Function And Development By Controlling The Assembly Of Microtubules And The Interaction Of Microtubules With Other Cytoplasmic Organelles. We Studied The Immunohistochemical Localization Of Maps 1, 2, 5, And Tau In The Intestinal Tissues Of Five Patients With Hirschsprung's Disease And In Five Normal Controls Using Monoclonal Antibodies. Microtubule-Associated Proteins 5 And Tau Proved To Be Excellent Enteric Neuronal Markers; They Were Specifically Located In The Nerve Cell Bodies And Processes Of Normal Intestine As Well As In The Abnormal Hypertrophied Nerve Fibers Of Aganglionic Colon. Fine Fibrillar Structures In The Neuroplasm Were Revealed In Greater Detail Than Were Those Obtained From Studies With Conventional Markers, Including Neuron-Specific Enolase, S-100 Protein, And Neurofilament Protein. A Slight Reduction Of Maps 5 And Tau Immunoreactivity Was Observed In The Aganglionic Colon Compared With Normal Colon. Microtubule-Associated Proteins 1 And 2 Were Absent From The Nerve Fibers In Both Normal And Aganglionic Colon. This Study Suggests That Immunostaining For Maps 5 And Tau May Be Superior To Other Immunohistochemical Methods For Diagnosing Hirschsprung's Disease; However, In View Of Its Limited Retrospective Nature These Findings Need To Be Corroborated By A Large Prospective Evaluation.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_US
dc.relation.ispartofHuman Pathologyen_US
dc.titleAn Immunohistochemical Study Of Neuronal Microtubule-Associated Proteins In Hirschsprung's Diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0046-8177(93)90092-U-
dc.identifier.pmid8491483-
dc.identifier.scopuseid_2-s2.0-0027309517-
dc.identifier.volume24-
dc.identifier.issue4-
dc.identifier.spage424-
dc.identifier.epage431-
dc.identifier.isiWOS:A1993KX35400014-

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