File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cytokine Response Of Neonates To Surgery

TitleCytokine Response Of Neonates To Surgery
Authors
Issue Date1994
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 1994, v. 29 n. 6, p. 794-797 How to Cite?
AbstractCytokines Are Early Responders In The Cascade Of Host Mediators After Injury. The Cytokine Response In Neonates Following Surgery And Its Prognostic Significance Were Studied Prospectively. Twenty-One Patients (Oesophageal Atresia [5], Congenital Diaphragmatic Hernia [4], Exomphalos [4], Patent Vitellointestinal Duct [1], Anorectal Anomaly [2], Choledochal Cyst [1], Renal Cyst [1], Ovarian Cyst [1], Myelomeningocoele [1], And Pyloric Stenosis [1]) Operated On At A Median Age Of 3 Days (Range, 1 To 24 Days) And 12 Age-Matched Controls Were Included In The Study. Plasma Samples Were Obtained Once In The Controls, And Serially Preoperatively And At 1, 3, 6, 12, 24, 36, And 48 Hours Postoperatively In The Patients. The Levels Of The Cytokines, Interleukin-6 (Il-6), And Interleukin-8 (Il-8) Were Measured Using The Enzyme-Linked Immunosorbent Assay (Elisa) Technique. The Median Plasma Levels Of Il-6 And Il-8 In Normal Controls Were 2.4 Pg/Ml And 92.0 Pg/Ml, Respectively. Of The 21 Patients, Four Had Postoperative Complications (Pulmonary Consolidation [2], Septicaemia [1], And Oesophageal Leak [1]) Between Days 4 And 6. All 17 Uncomplicated Cases Had An Increase In Il-6 And Il-8 In The Early Postoperative Period, With The Peak Occurring Within 12 Hours After Surgery. The Mean (±Sem) Peak Levels Of Il-6 And Il-8 In Uncomplicated Cases Were Of 92.6 ± 15.8 Pg/Ml And 230.3 ± 45.3 Pg/Ml, Respectively. In The Four Complicated Cases, There Was A Disproportionately Higher Increase In Both Il-6 (Peaks, 305.0, 125.0, 240.0, And 220.0 Pg/Ml) And Il-8 (Peaks, 1500.0, 340.0, 245.0, 355.0 And Pg/Ml), Which Preceded The Clinical Onset Of Complications. The Early Postoperative Increases In Plasma Il-6 And Il-8 Probably Represent The Stress Response Of Neonates To Surgery. Furthermore, The Association Of An Exaggerated Increase In Postoperative Levels Of Plasma Il-6 And Il-8 And Postoperative Complications May Have Prognostic Significance.
Persistent Identifierhttp://hdl.handle.net/10722/220786
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, TMen_US
dc.contributor.authorTam, PKHen_US
dc.date.accessioned2015-10-19T03:40:20Z-
dc.date.available2015-10-19T03:40:20Z-
dc.date.issued1994-
dc.identifier.citationJournal Of Pediatric Surgery, 1994, v. 29 n. 6, p. 794-797en_US
dc.identifier.issn0022-3468-
dc.identifier.urihttp://hdl.handle.net/10722/220786-
dc.description.abstractCytokines Are Early Responders In The Cascade Of Host Mediators After Injury. The Cytokine Response In Neonates Following Surgery And Its Prognostic Significance Were Studied Prospectively. Twenty-One Patients (Oesophageal Atresia [5], Congenital Diaphragmatic Hernia [4], Exomphalos [4], Patent Vitellointestinal Duct [1], Anorectal Anomaly [2], Choledochal Cyst [1], Renal Cyst [1], Ovarian Cyst [1], Myelomeningocoele [1], And Pyloric Stenosis [1]) Operated On At A Median Age Of 3 Days (Range, 1 To 24 Days) And 12 Age-Matched Controls Were Included In The Study. Plasma Samples Were Obtained Once In The Controls, And Serially Preoperatively And At 1, 3, 6, 12, 24, 36, And 48 Hours Postoperatively In The Patients. The Levels Of The Cytokines, Interleukin-6 (Il-6), And Interleukin-8 (Il-8) Were Measured Using The Enzyme-Linked Immunosorbent Assay (Elisa) Technique. The Median Plasma Levels Of Il-6 And Il-8 In Normal Controls Were 2.4 Pg/Ml And 92.0 Pg/Ml, Respectively. Of The 21 Patients, Four Had Postoperative Complications (Pulmonary Consolidation [2], Septicaemia [1], And Oesophageal Leak [1]) Between Days 4 And 6. All 17 Uncomplicated Cases Had An Increase In Il-6 And Il-8 In The Early Postoperative Period, With The Peak Occurring Within 12 Hours After Surgery. The Mean (±Sem) Peak Levels Of Il-6 And Il-8 In Uncomplicated Cases Were Of 92.6 ± 15.8 Pg/Ml And 230.3 ± 45.3 Pg/Ml, Respectively. In The Four Complicated Cases, There Was A Disproportionately Higher Increase In Both Il-6 (Peaks, 305.0, 125.0, 240.0, And 220.0 Pg/Ml) And Il-8 (Peaks, 1500.0, 340.0, 245.0, 355.0 And Pg/Ml), Which Preceded The Clinical Onset Of Complications. The Early Postoperative Increases In Plasma Il-6 And Il-8 Probably Represent The Stress Response Of Neonates To Surgery. Furthermore, The Association Of An Exaggerated Increase In Postoperative Levels Of Plasma Il-6 And Il-8 And Postoperative Complications May Have Prognostic Significance.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.titleCytokine Response Of Neonates To Surgeryen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0022-3468(94)90373-5-
dc.identifier.pmid8078024-
dc.identifier.scopuseid_2-s2.0-0028355878-
dc.identifier.volume29-
dc.identifier.issue6-
dc.identifier.spage794-
dc.identifier.epage797-
dc.identifier.isiWOS:A1994NR30000021-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats