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Article: The Extracellular Matrix Components, Tenascin And Fibronectin, In Hirschsprung's Disease: An Immunohistochemical Study

TitleThe Extracellular Matrix Components, Tenascin And Fibronectin, In Hirschsprung's Disease: An Immunohistochemical Study
Authors
Issue Date1994
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 1994, v. 29 n. 10, p. 1302-1306 How to Cite?
AbstractPrevious In Vitro Studies Have Suggested That Successful Neural Crest Cell Migration In The Developing Gut Could Be Influenced By The Composition Of The Extracellular Matrix Components, Tenascin And Fibronectin. The Authors Aimed To Gain Insight Into The Pathogenesis Of Hirschsprung's Disease (Hd) By Studying The Distribution Of Tenascin And Fibronectin In Bowel Specimens Of Patients With Hd. Immunohistochemical Examination Was Performed In Specimens From 10 Hd Patients (8 Aganglionic, 5 Transitional, And 10 Normoganglionic Zones) And 18 Age- And Site-Matched Controls Undergoing Other Types Of Gastrointestinal Surgery. The Distribution Of Tenascin Was Restricted To The Basement Membranes Of The Smooth Muscle And Vasculature, And In The Basement Membranes Surrounding Neuronal Ganglia In All The Controls And In 10 Proximal Normoganglionic Hd Specimens. More Intense Tenascin Immunofluorescence Was Observed In The Smooth Muscle Basement Membranes Of The Muscularis Externa Of Eight Aganglionic And Five Transitional Zones Of Hd. Widespread Distribution Of Fibronectin Was Found In All The Basement Membranes As Well As In The Lamina Propria And Submucosa Of All Control And 10 Normoganglionic Hd Sections. However, More Intense Immunofluorescence With Fibronectin Was Observed In All The Layers Of Eight Aganglionic And Five Transitional Zones Of Hd Specimens. The Present Findings Show That The Mesenchymal And Basement Membrane Extracellular Matrix Constitution Is Abnormal In The Affected Bowel Of Hd. Although A Causal Relationship Has Not Been Demonstrated, Corroborative Evidence From Earlier Animal Experiments In Other Studies Suggests That The Extracellular Matrix Abnormalities May Contribute To The Pathogenesis Of Hd.
Persistent Identifierhttp://hdl.handle.net/10722/220784
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorParikh, DHen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorVan Velzen, Den_US
dc.contributor.authorEdgar, Den_US
dc.date.accessioned2015-10-19T03:38:36Z-
dc.date.available2015-10-19T03:38:36Z-
dc.date.issued1994-
dc.identifier.citationJournal Of Pediatric Surgery, 1994, v. 29 n. 10, p. 1302-1306en_US
dc.identifier.issn0022-3468-
dc.identifier.urihttp://hdl.handle.net/10722/220784-
dc.description.abstractPrevious In Vitro Studies Have Suggested That Successful Neural Crest Cell Migration In The Developing Gut Could Be Influenced By The Composition Of The Extracellular Matrix Components, Tenascin And Fibronectin. The Authors Aimed To Gain Insight Into The Pathogenesis Of Hirschsprung's Disease (Hd) By Studying The Distribution Of Tenascin And Fibronectin In Bowel Specimens Of Patients With Hd. Immunohistochemical Examination Was Performed In Specimens From 10 Hd Patients (8 Aganglionic, 5 Transitional, And 10 Normoganglionic Zones) And 18 Age- And Site-Matched Controls Undergoing Other Types Of Gastrointestinal Surgery. The Distribution Of Tenascin Was Restricted To The Basement Membranes Of The Smooth Muscle And Vasculature, And In The Basement Membranes Surrounding Neuronal Ganglia In All The Controls And In 10 Proximal Normoganglionic Hd Specimens. More Intense Tenascin Immunofluorescence Was Observed In The Smooth Muscle Basement Membranes Of The Muscularis Externa Of Eight Aganglionic And Five Transitional Zones Of Hd. Widespread Distribution Of Fibronectin Was Found In All The Basement Membranes As Well As In The Lamina Propria And Submucosa Of All Control And 10 Normoganglionic Hd Sections. However, More Intense Immunofluorescence With Fibronectin Was Observed In All The Layers Of Eight Aganglionic And Five Transitional Zones Of Hd Specimens. The Present Findings Show That The Mesenchymal And Basement Membrane Extracellular Matrix Constitution Is Abnormal In The Affected Bowel Of Hd. Although A Causal Relationship Has Not Been Demonstrated, Corroborative Evidence From Earlier Animal Experiments In Other Studies Suggests That The Extracellular Matrix Abnormalities May Contribute To The Pathogenesis Of Hd.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.titleThe Extracellular Matrix Components, Tenascin And Fibronectin, In Hirschsprung's Disease: An Immunohistochemical Studyen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0022-3468(94)90101-5-
dc.identifier.pmid7528797-
dc.identifier.scopuseid_2-s2.0-0028114726-
dc.identifier.volume29-
dc.identifier.issue10-
dc.identifier.spage1302-
dc.identifier.epage1306-
dc.identifier.isiWOS:A1994PL70400002-

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