File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The Immune Response Following Small Bowel Transplantation: Ii: A Very Early Cytokine Response In The Gut-Associated Lymphoid Tissue

TitleThe Immune Response Following Small Bowel Transplantation: Ii: A Very Early Cytokine Response In The Gut-Associated Lymphoid Tissue
Authors
Issue Date1997
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.com
Citation
Transplantation, 1997, v. 63 n. 8, p. 1118-1123 How to Cite?
AbstractThe Small Bowel Has A Unique Amount Of Closely Associated Lymphoid Tissue In The Form Of Mesenteric Lymph Nodes (Mlns) And Peyer's Patches (Pps). It Is Rather Unclear How This May Affect The Immune Response To Transplants Involving Small Bowel. It Is Clear, However, That Host-Derived Leukocytes Infiltrate This Lymphoid Tissue Very Rapidly After Transplantation Of Small Bowel, Which Suggests The Possibility Of An Early Immune Response Within This Compartment. To Investigate This Possibility, We Analyzed, Using A Semiquantitative Reverse Transcriptase-Polymerase Chain Reaction, The Level Of Cytokine Transcripts Within Isolated Mlns And Pps For The First 7 Days After Small Bowel Transplantation. Heterotopic Small Bowel (N=32) Transplants Were Performed Using The Following Rat Strain Combinations: Syngeneic Lewis (Lew→Lew (N=8), Blood Group D Agouti (Da)→Da (N=8), Allogeneic Lew→Da (N=8), And Allogeneic Da →Lew (N=8). Two Rats From Each Group Were Killed At 1, 3, 5, And 7 Days After Transplantation. Rna Was Prepared Separately From Pps And Mlns Before Analysis Of Transcripts For Interleukin (Il) 2, Il-4, Il- 10, Il-6, Il-1Α, And Interferon (Ifn) Γ. No Increase In Transcripts For Il- 2 Or Il-10 Was Observed In Either Pps Or Mlns Of Syngeneic Grafts. A Small Rise In Il-6, Il-Α, And Ifn-Γ Transcripts Was Seen In Mlns And Ifn-Γ Transcripts In Pps Of Syngeneic Grafts. In Contrast, In Allografts An Extremely Early Increase In Cytokine Transcripts Was Observed; All Cytokine Transcripts Tested Were Elevated Within The First 24 Hr After Transplantation. Indeed, The Peak Response Of Both Il-2 And Il-10 Occurred Within 1 To 3 Days After Grafting. His Early Immune Response In The Lymphoid Tissue May Not Be Controlled By Immunosuppression Delivered Only At The Time Of Transplantation, And Therefore May He Responsible For The Difficulty In Achieving Adequate Immunosuppression In Small Bowel Transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/220772
ISSN
2015 Impact Factor: 3.69
2015 SCImago Journal Rankings: 1.699
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorToogood, GJen_US
dc.contributor.authorRankin, AMen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorMorris, PJen_US
dc.contributor.authorDallman, MJen_US
dc.date.accessioned2015-10-19T01:22:53Z-
dc.date.available2015-10-19T01:22:53Z-
dc.date.issued1997-
dc.identifier.citationTransplantation, 1997, v. 63 n. 8, p. 1118-1123en_US
dc.identifier.issn0041-1337-
dc.identifier.urihttp://hdl.handle.net/10722/220772-
dc.description.abstractThe Small Bowel Has A Unique Amount Of Closely Associated Lymphoid Tissue In The Form Of Mesenteric Lymph Nodes (Mlns) And Peyer's Patches (Pps). It Is Rather Unclear How This May Affect The Immune Response To Transplants Involving Small Bowel. It Is Clear, However, That Host-Derived Leukocytes Infiltrate This Lymphoid Tissue Very Rapidly After Transplantation Of Small Bowel, Which Suggests The Possibility Of An Early Immune Response Within This Compartment. To Investigate This Possibility, We Analyzed, Using A Semiquantitative Reverse Transcriptase-Polymerase Chain Reaction, The Level Of Cytokine Transcripts Within Isolated Mlns And Pps For The First 7 Days After Small Bowel Transplantation. Heterotopic Small Bowel (N=32) Transplants Were Performed Using The Following Rat Strain Combinations: Syngeneic Lewis (Lew→Lew (N=8), Blood Group D Agouti (Da)→Da (N=8), Allogeneic Lew→Da (N=8), And Allogeneic Da →Lew (N=8). Two Rats From Each Group Were Killed At 1, 3, 5, And 7 Days After Transplantation. Rna Was Prepared Separately From Pps And Mlns Before Analysis Of Transcripts For Interleukin (Il) 2, Il-4, Il- 10, Il-6, Il-1Α, And Interferon (Ifn) Γ. No Increase In Transcripts For Il- 2 Or Il-10 Was Observed In Either Pps Or Mlns Of Syngeneic Grafts. A Small Rise In Il-6, Il-Α, And Ifn-Γ Transcripts Was Seen In Mlns And Ifn-Γ Transcripts In Pps Of Syngeneic Grafts. In Contrast, In Allografts An Extremely Early Increase In Cytokine Transcripts Was Observed; All Cytokine Transcripts Tested Were Elevated Within The First 24 Hr After Transplantation. Indeed, The Peak Response Of Both Il-2 And Il-10 Occurred Within 1 To 3 Days After Grafting. His Early Immune Response In The Lymphoid Tissue May Not Be Controlled By Immunosuppression Delivered Only At The Time Of Transplantation, And Therefore May He Responsible For The Difficulty In Achieving Adequate Immunosuppression In Small Bowel Transplantation.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.transplantjournal.comen_US
dc.relation.ispartofTransplantationen_US
dc.titleThe Immune Response Following Small Bowel Transplantation: Ii: A Very Early Cytokine Response In The Gut-Associated Lymphoid Tissueen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9133473-
dc.identifier.scopuseid_2-s2.0-0030892596-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030892596&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume63-
dc.identifier.issue8-
dc.identifier.spage1118-
dc.identifier.epage1123-
dc.identifier.isiWOS:A1997WW66000011-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats