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Article: Regulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role?

TitleRegulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role?
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trre
Citation
Transplantation Reviews, 2010, v. 24 n. 2, p. 52-66 How to Cite?
AbstractDespite Tremendous Improvements In Short-Term Renal Allograft Survival, Many Patients Still Have Chronic Rejection Or Side Effects Of Nonspecific Immunosuppression. The Discovery Of Foxp3+ Regulatory T Cells (Tregs) Has Revolutionized The Concepts In Immunoregulation And Offers Perspectives For Overcoming Rejection. Recently, A Subset Of Foxp3+Cd39+ Effector/Memory-Like Tregs (Trem) Was Identified. The Role Of Cd39+ Tregs In Immunoregulation Is Supported By The Occurrence Of Alopecia Areata And Experimental Autoimmune Encephalomyelitis In Cd39-Deficient Mice And By The Failure Of Cd39- Tregs To Suppress Contact Hypersensitivity. In Humans, Cd39 Polymorphisms Have Been Associated With Diabetes And Nephropathy, And Multiple Sclerosis Patients Have Reduced Numbers Of Blood Cd39+ Tregs. Preliminary Experiments In A Murine Transplantation Model Showed That Cd39+ Tregs Can Determine Allograft Outcome. Cd39 Degrades The Extracellular Adenosine Triphosphate (Atp) Released During Tissue Injury, Which Otherwise Would Trigger Inflammation. Currently, Our Groups Are Assessing The Role Of Cd39+ Tregs And Extracellular Atp Metabolism In Clinical Transplantation And Whether Tolerogenic Treg Profiles Possess Immunopredictive Value, Envisioning The Development Of Clinical Trials Using Cd39+ Treg-Based Vaccination For Autoimmunity Or Transplantation. This Is A Comprehensive Review On The Fundamentals Of Treg Biology, The Potential Role Of Atp Metabolism In Immunoregulation, And The Potential Use Of Treg-Based Immunotherapy In Transplantation. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/220766
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSalcido-Ochoa, Fen_US
dc.contributor.authorTsang, Jen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorFalk, Ken_US
dc.contributor.authorRotzschke, Oen_US
dc.date.accessioned2015-10-16T08:10:09Z-
dc.date.available2015-10-16T08:10:09Z-
dc.date.issued2010-
dc.identifier.citationTransplantation Reviews, 2010, v. 24 n. 2, p. 52-66en_US
dc.identifier.issn0955-470X-
dc.identifier.urihttp://hdl.handle.net/10722/220766-
dc.description.abstractDespite Tremendous Improvements In Short-Term Renal Allograft Survival, Many Patients Still Have Chronic Rejection Or Side Effects Of Nonspecific Immunosuppression. The Discovery Of Foxp3+ Regulatory T Cells (Tregs) Has Revolutionized The Concepts In Immunoregulation And Offers Perspectives For Overcoming Rejection. Recently, A Subset Of Foxp3+Cd39+ Effector/Memory-Like Tregs (Trem) Was Identified. The Role Of Cd39+ Tregs In Immunoregulation Is Supported By The Occurrence Of Alopecia Areata And Experimental Autoimmune Encephalomyelitis In Cd39-Deficient Mice And By The Failure Of Cd39- Tregs To Suppress Contact Hypersensitivity. In Humans, Cd39 Polymorphisms Have Been Associated With Diabetes And Nephropathy, And Multiple Sclerosis Patients Have Reduced Numbers Of Blood Cd39+ Tregs. Preliminary Experiments In A Murine Transplantation Model Showed That Cd39+ Tregs Can Determine Allograft Outcome. Cd39 Degrades The Extracellular Adenosine Triphosphate (Atp) Released During Tissue Injury, Which Otherwise Would Trigger Inflammation. Currently, Our Groups Are Assessing The Role Of Cd39+ Tregs And Extracellular Atp Metabolism In Clinical Transplantation And Whether Tolerogenic Treg Profiles Possess Immunopredictive Value, Envisioning The Development Of Clinical Trials Using Cd39+ Treg-Based Vaccination For Autoimmunity Or Transplantation. This Is A Comprehensive Review On The Fundamentals Of Treg Biology, The Potential Role Of Atp Metabolism In Immunoregulation, And The Potential Use Of Treg-Based Immunotherapy In Transplantation. © 2010 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trreen_US
dc.relation.ispartofTransplantation Reviewsen_US
dc.titleRegulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role?en_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.trre.2010.01.002-
dc.identifier.pmid20153159-
dc.identifier.scopuseid_2-s2.0-77950865221-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950865221&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24-
dc.identifier.issue2-
dc.identifier.spage52-
dc.identifier.epage66-
dc.identifier.isiWOS:000208545300002-

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