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Article: Well-Differentiated Thyroid Carcinoma In Hong Kong Chinese Patients Under 21 Years Of Age: A 35-Year Experience

TitleWell-Differentiated Thyroid Carcinoma In Hong Kong Chinese Patients Under 21 Years Of Age: A 35-Year Experience
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jamcollsurg
Citation
Journal Of The American College Of Surgeons, 2002, v. 194 n. 6, p. 711-716 How to Cite?
AbstractBackground: Sporadic Well-Differentiated Thyroid Cancer Is An Uncommon Condition In Children, Adolescents, And Young Adults. It Is Associated With Distinct Clinicopathologic Features And Prognosis. The Present Study Reviews Our Experience In Management Of This Condition In Ethnic Chinese In Hong Kong. Study Design: A Retrospective Study Was Performed To Review The Clinicopathologic Features And Outcomes Of 34 Patients Less Than 21 Years Of Age With Well-Differentiated Thyroid Carcinoma Over A 35-Year Period. Median Followup Was 15.2 Years (Range 1 To 32.5 Years). Results: There Were 27 Girls And 7 Boys With A Median Age Of 19 Years (Range 10 To 21 Years). None Had Previous History Of Irradiation. Twenty-Eight Patients Had Papillary And Six Had Follicular Carcinomas. Operative Procedures Included Total Thyroidectomy (N = 27) And Unilateral Lobectomy (N = 7) With Concomitant Neck Dissection Performed In Nine Patients. The Median Tumor Size Was 2 Cm And Extrathyroidal Invasion Was Present In 19 Tumors. Adjuvant Radioactive Iodine Treatment Was Administered To 18 Patients After Total Thyroidectomy. Disease Progression Or Recurrence Rate Was 24% And 27% At 5 And 10 Years, Respectively. The Presence Of Lymph Node Metastases Was Associated With A Higher Incidence Of Disease Recurrence. One Patient With Advanced Local Disease Died From Tumor Bed Recurrence With Anaplastic Transformation 18 Years After The Initial Operation. Conclusions: Well-Differentiated Thyroid Carcinoma Is A Relatively Indolent Tumor Associated With Good Prognosis In Young Patients. Although Death From This Condition Is Rare, Recurrence Is Frequent And Longterm Followup Is Necessary. © 2002 By The American College Of Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/220764
ISSN
2015 Impact Factor: 4.257
2015 SCImago Journal Rankings: 2.604
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, Y-Men_US
dc.contributor.authorLo, C-Yen_US
dc.contributor.authorLam, K-Yen_US
dc.contributor.authorWan, K-Yen_US
dc.contributor.authorTam, PKHen_US
dc.date.accessioned2015-10-16T08:08:32Z-
dc.date.available2015-10-16T08:08:32Z-
dc.date.issued2002-
dc.identifier.citationJournal Of The American College Of Surgeons, 2002, v. 194 n. 6, p. 711-716en_US
dc.identifier.issn1072-7515-
dc.identifier.urihttp://hdl.handle.net/10722/220764-
dc.description.abstractBackground: Sporadic Well-Differentiated Thyroid Cancer Is An Uncommon Condition In Children, Adolescents, And Young Adults. It Is Associated With Distinct Clinicopathologic Features And Prognosis. The Present Study Reviews Our Experience In Management Of This Condition In Ethnic Chinese In Hong Kong. Study Design: A Retrospective Study Was Performed To Review The Clinicopathologic Features And Outcomes Of 34 Patients Less Than 21 Years Of Age With Well-Differentiated Thyroid Carcinoma Over A 35-Year Period. Median Followup Was 15.2 Years (Range 1 To 32.5 Years). Results: There Were 27 Girls And 7 Boys With A Median Age Of 19 Years (Range 10 To 21 Years). None Had Previous History Of Irradiation. Twenty-Eight Patients Had Papillary And Six Had Follicular Carcinomas. Operative Procedures Included Total Thyroidectomy (N = 27) And Unilateral Lobectomy (N = 7) With Concomitant Neck Dissection Performed In Nine Patients. The Median Tumor Size Was 2 Cm And Extrathyroidal Invasion Was Present In 19 Tumors. Adjuvant Radioactive Iodine Treatment Was Administered To 18 Patients After Total Thyroidectomy. Disease Progression Or Recurrence Rate Was 24% And 27% At 5 And 10 Years, Respectively. The Presence Of Lymph Node Metastases Was Associated With A Higher Incidence Of Disease Recurrence. One Patient With Advanced Local Disease Died From Tumor Bed Recurrence With Anaplastic Transformation 18 Years After The Initial Operation. Conclusions: Well-Differentiated Thyroid Carcinoma Is A Relatively Indolent Tumor Associated With Good Prognosis In Young Patients. Although Death From This Condition Is Rare, Recurrence Is Frequent And Longterm Followup Is Necessary. © 2002 By The American College Of Surgeons.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jamcollsurgen_US
dc.relation.ispartofJournal Of The American College Of Surgeonsen_US
dc.subjectChemicals And Cas Registry Numbersen_US
dc.titleWell-Differentiated Thyroid Carcinoma In Hong Kong Chinese Patients Under 21 Years Of Age: A 35-Year Experienceen_US
dc.typeArticleen_US
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1072-7515(02)01139-0-
dc.identifier.pmid12081061-
dc.identifier.scopuseid_2-s2.0-0036278634-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036278634&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume194-
dc.identifier.issue6-
dc.identifier.spage711-
dc.identifier.epage716-
dc.identifier.isiWOS:000176204800003-

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