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Article: Pluripotent stem cell for modeling neurological diseases

TitlePluripotent stem cell for modeling neurological diseases
Authors
KeywordsEmbryonic stem cells
Neurodevelopmental diseases and neurodegenerative diseases
Induced pluriopotent stem cells
Issue Date2013
Citation
Experimental Cell Research, 2013, v. 319, n. 2, p. 177-184 How to Cite?
AbstractThe availability of human pluriopotent stem cells, embryonic (ESC) and induced pluriopotent (iPSC) stem cells, not only can be a renewable source for investigating the early human development, etiology and progression of different diseases but also recapitulating the disease with the same genomic materials of the patient. In particular, specific neuronal subtypes generated from the patient ESC/iPSCs has become a source for studying disease mechanisms underlying different neurological disorders and allowed drug discovery. In this review, we summarize the recent advances in establishing patient ESC/iPSC to model various neurological diseases. We will also discuss the challenges and limitations of the current disease models and their potential future applications for untangling the unknowns in neurological disorders. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/220738
ISSN
2015 Impact Factor: 3.378
2015 SCImago Journal Rankings: 1.900

 

DC FieldValueLanguage
dc.contributor.authorYung, Jasmine Sum Yee-
dc.contributor.authorTam, Paul Kwong Hang-
dc.contributor.authorNgan, Elly Sau Wai-
dc.date.accessioned2015-10-16T06:50:25Z-
dc.date.available2015-10-16T06:50:25Z-
dc.date.issued2013-
dc.identifier.citationExperimental Cell Research, 2013, v. 319, n. 2, p. 177-184-
dc.identifier.issn0014-4827-
dc.identifier.urihttp://hdl.handle.net/10722/220738-
dc.description.abstractThe availability of human pluriopotent stem cells, embryonic (ESC) and induced pluriopotent (iPSC) stem cells, not only can be a renewable source for investigating the early human development, etiology and progression of different diseases but also recapitulating the disease with the same genomic materials of the patient. In particular, specific neuronal subtypes generated from the patient ESC/iPSCs has become a source for studying disease mechanisms underlying different neurological disorders and allowed drug discovery. In this review, we summarize the recent advances in establishing patient ESC/iPSC to model various neurological diseases. We will also discuss the challenges and limitations of the current disease models and their potential future applications for untangling the unknowns in neurological disorders. © 2012 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofExperimental Cell Research-
dc.subjectEmbryonic stem cells-
dc.subjectNeurodevelopmental diseases and neurodegenerative diseases-
dc.subjectInduced pluriopotent stem cells-
dc.titlePluripotent stem cell for modeling neurological diseases-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.yexcr.2012.11.007-
dc.identifier.pmid23159386-
dc.identifier.scopuseid_2-s2.0-84870763956-
dc.identifier.volume319-
dc.identifier.issue2-
dc.identifier.spage177-
dc.identifier.epage184-
dc.identifier.eissn1090-2422-

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