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- Publisher Website: 10.1016/j.yexcr.2012.11.007
- Scopus: eid_2-s2.0-84870763956
- PMID: 23159386
- WOS: WOS:000312465900010
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Article: Pluripotent stem cell for modeling neurological diseases
Title | Pluripotent stem cell for modeling neurological diseases |
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Authors | |
Keywords | Embryonic stem cells Neurodevelopmental diseases and neurodegenerative diseases Induced pluriopotent stem cells |
Issue Date | 2013 |
Citation | Experimental Cell Research, 2013, v. 319, n. 2, p. 177-184 How to Cite? |
Abstract | The availability of human pluriopotent stem cells, embryonic (ESC) and induced pluriopotent (iPSC) stem cells, not only can be a renewable source for investigating the early human development, etiology and progression of different diseases but also recapitulating the disease with the same genomic materials of the patient. In particular, specific neuronal subtypes generated from the patient ESC/iPSCs has become a source for studying disease mechanisms underlying different neurological disorders and allowed drug discovery. In this review, we summarize the recent advances in establishing patient ESC/iPSC to model various neurological diseases. We will also discuss the challenges and limitations of the current disease models and their potential future applications for untangling the unknowns in neurological disorders. © 2012 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/220738 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 0.947 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yung, Jasmine Sum Yee | - |
dc.contributor.author | Tam, Paul Kwong Hang | - |
dc.contributor.author | Ngan, Elly Sau Wai | - |
dc.date.accessioned | 2015-10-16T06:50:25Z | - |
dc.date.available | 2015-10-16T06:50:25Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Experimental Cell Research, 2013, v. 319, n. 2, p. 177-184 | - |
dc.identifier.issn | 0014-4827 | - |
dc.identifier.uri | http://hdl.handle.net/10722/220738 | - |
dc.description.abstract | The availability of human pluriopotent stem cells, embryonic (ESC) and induced pluriopotent (iPSC) stem cells, not only can be a renewable source for investigating the early human development, etiology and progression of different diseases but also recapitulating the disease with the same genomic materials of the patient. In particular, specific neuronal subtypes generated from the patient ESC/iPSCs has become a source for studying disease mechanisms underlying different neurological disorders and allowed drug discovery. In this review, we summarize the recent advances in establishing patient ESC/iPSC to model various neurological diseases. We will also discuss the challenges and limitations of the current disease models and their potential future applications for untangling the unknowns in neurological disorders. © 2012 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Experimental Cell Research | - |
dc.subject | Embryonic stem cells | - |
dc.subject | Neurodevelopmental diseases and neurodegenerative diseases | - |
dc.subject | Induced pluriopotent stem cells | - |
dc.title | Pluripotent stem cell for modeling neurological diseases | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.yexcr.2012.11.007 | - |
dc.identifier.pmid | 23159386 | - |
dc.identifier.scopus | eid_2-s2.0-84870763956 | - |
dc.identifier.volume | 319 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 177 | - |
dc.identifier.epage | 184 | - |
dc.identifier.eissn | 1090-2422 | - |
dc.identifier.isi | WOS:000312465900010 | - |
dc.identifier.issnl | 0014-4827 | - |