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Article: Clinical and manometric evaluations of anorectal function in patients after transanal endorectal pull-through operation for Hirschsprung's disease: A multicentre study

TitleClinical and manometric evaluations of anorectal function in patients after transanal endorectal pull-through operation for Hirschsprung's disease: A multicentre study
Authors
KeywordsTransanal endorectal pull-through operation
Hirschsprung's disease
Anorectomanometry
Issue Date2015
Citation
Surgical Practice, 2015, v. 19, n. 3, p. 113-119 How to Cite?
Abstract© 2015 College of Surgeons of Hong Kong. Aim: Transanal endorectal pull-through (TEPT) operation is one the most popular operations for Hirschsprung's disease. This aim of the present study was to evaluate its outcome by clinical and manometric assessments. Patients and Methods: This study was a multicentred study involving all three paediatric surgical centres under the Hospital Authority in Hong Kong. All patients, over the age of 3years, who had undergone primary TEPT operation for more than 1year, were included in the present study. Clinical evaluation with bowel function score (BFS) and anorectomanometry were carried out. A BFS >18 and sphincter resting pressure between 30mmHg and 60mmHg were considered normal. Those with concomitant anorectal/neurological anomaly or who could not cooperate were excluded. Results: A total of 37 patients were enrolled in this study. The median age was 60months (range: 36-144months), and the median age at the time of operation was 3months (range: 0.5-60months). With respect to functional outcomes, six patients (16.2 per cent) suffered from constipation, but more than two-thirds of patients had satisfactory stool consistency, as well as frequency. Sixteen patients (43.2 per cent) had no report of any soiling. For the BFS, 26 patients had a BFS above 18, with the median value being 16 (range: 7-20). Manometric assessment revealed that 27 patients (72.9 per cent) had sphincteric resting pressure within the normal value, and the median value was 45mmHg (range: 14-79mmHg). Rectoanal inhibitory reflex was present in six patients (16.2 per cent), and the median value for the volume of air to elicit the first anal sensation was 41mL (range: 18-126mL). Using univariate analysis, long segment disease was identified as a risk factor for developing soiling of more than two times per week [relative risk (RR): 1.87, 95 per cent confidence interval (CI):1.03-2.22, P=0.05], whereas the creation of stoma (RR: 1.69, 95 per cent CI: 1.41-2.14, P=0.04) and occurrence of postoperative enterocolitis (RR: 1.58, 95 per cent CI: 1.36-1.0, P=0.04) were risk factors for abnormal bowel function score. There was no significant risk factor identified for abnormal manometric results. Lastly, patients with abnormal sphincter resting pressure detected in the anorectomanometry study were also more likely to have an abnormal BFS. Conclusion: Most patients have satisfactory clinical and manometric outcomes after primary TEPT operation. Anorectomanometry findings can predict clinical outcomes. Patients with long segment disease, development of enterocolitis and stoma creation before operation will need more attention, as they are prone to develop abnormal bowel function. Early interventions, such as manometric assessment and proper bowel management, are recommended in order to correct bowel dysfunction, as well enabling patients to have a better quality of life.
Persistent Identifierhttp://hdl.handle.net/10722/220722
ISSN
2013 Impact Factor: 0.172
2015 SCImago Journal Rankings: 0.121
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChung, Patrick Ho Yu-
dc.contributor.authorWong, Kenneth Kak Yuen-
dc.contributor.authorLeung, Jessie Ling-
dc.contributor.authorTam, Paul Kwong Hang-
dc.contributor.authorChung, Kenneth Lap Yan-
dc.contributor.authorLeung, Michael Wai Yip-
dc.contributor.authorChao, Nicholas Sih Yin-
dc.contributor.authorLiu, Kelvin Kam Wing-
dc.contributor.authorTsui, Bess Siu Yan-
dc.contributor.authorChan, Edwin Kin Wai-
dc.contributor.authorTam, Peter Yuk Him-
dc.contributor.authorLee, Kim Hung-
dc.date.accessioned2015-10-16T06:50:22Z-
dc.date.available2015-10-16T06:50:22Z-
dc.date.issued2015-
dc.identifier.citationSurgical Practice, 2015, v. 19, n. 3, p. 113-119-
dc.identifier.issn1744-1625-
dc.identifier.urihttp://hdl.handle.net/10722/220722-
dc.description.abstract© 2015 College of Surgeons of Hong Kong. Aim: Transanal endorectal pull-through (TEPT) operation is one the most popular operations for Hirschsprung's disease. This aim of the present study was to evaluate its outcome by clinical and manometric assessments. Patients and Methods: This study was a multicentred study involving all three paediatric surgical centres under the Hospital Authority in Hong Kong. All patients, over the age of 3years, who had undergone primary TEPT operation for more than 1year, were included in the present study. Clinical evaluation with bowel function score (BFS) and anorectomanometry were carried out. A BFS >18 and sphincter resting pressure between 30mmHg and 60mmHg were considered normal. Those with concomitant anorectal/neurological anomaly or who could not cooperate were excluded. Results: A total of 37 patients were enrolled in this study. The median age was 60months (range: 36-144months), and the median age at the time of operation was 3months (range: 0.5-60months). With respect to functional outcomes, six patients (16.2 per cent) suffered from constipation, but more than two-thirds of patients had satisfactory stool consistency, as well as frequency. Sixteen patients (43.2 per cent) had no report of any soiling. For the BFS, 26 patients had a BFS above 18, with the median value being 16 (range: 7-20). Manometric assessment revealed that 27 patients (72.9 per cent) had sphincteric resting pressure within the normal value, and the median value was 45mmHg (range: 14-79mmHg). Rectoanal inhibitory reflex was present in six patients (16.2 per cent), and the median value for the volume of air to elicit the first anal sensation was 41mL (range: 18-126mL). Using univariate analysis, long segment disease was identified as a risk factor for developing soiling of more than two times per week [relative risk (RR): 1.87, 95 per cent confidence interval (CI):1.03-2.22, P=0.05], whereas the creation of stoma (RR: 1.69, 95 per cent CI: 1.41-2.14, P=0.04) and occurrence of postoperative enterocolitis (RR: 1.58, 95 per cent CI: 1.36-1.0, P=0.04) were risk factors for abnormal bowel function score. There was no significant risk factor identified for abnormal manometric results. Lastly, patients with abnormal sphincter resting pressure detected in the anorectomanometry study were also more likely to have an abnormal BFS. Conclusion: Most patients have satisfactory clinical and manometric outcomes after primary TEPT operation. Anorectomanometry findings can predict clinical outcomes. Patients with long segment disease, development of enterocolitis and stoma creation before operation will need more attention, as they are prone to develop abnormal bowel function. Early interventions, such as manometric assessment and proper bowel management, are recommended in order to correct bowel dysfunction, as well enabling patients to have a better quality of life.-
dc.languageeng-
dc.relation.ispartofSurgical Practice-
dc.subjectTransanal endorectal pull-through operation-
dc.subjectHirschsprung's disease-
dc.subjectAnorectomanometry-
dc.titleClinical and manometric evaluations of anorectal function in patients after transanal endorectal pull-through operation for Hirschsprung's disease: A multicentre study-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1744-1633.12122-
dc.identifier.scopuseid_2-s2.0-84933505192-
dc.identifier.hkuros247421-
dc.identifier.volume19-
dc.identifier.issue3-
dc.identifier.spage113-
dc.identifier.epage119-
dc.identifier.eissn1744-1633-
dc.identifier.isiWOS:000359844100005-

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