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Conference Paper: T1 rho MRI quantitative proteoglycan profiling of lumbar disc displacement

TitleT1 rho MRI quantitative proteoglycan profiling of lumbar disc displacement
Authors
Issue Date2015
PublisherSICOT.
Citation
36th SICOT Orthopaedic World Congress, Guangzhou, China, 17-19 September 2015 How to Cite?
AbstractINTRODUCTION: Controversy exists whether disc displacement is associated with disc degeneration, and in vivo proteoglycan concentration of disc displacement is speculative. Signal intensity on T2-weighted (T2W) MRI provides a qualitative snap-shot of disc integrity, but is not reliable and lacks quantification. T1-rho MRI of the discs is shown to quantitatively represent proteoglycan concentration. This imaging study addressed the “proteoglycan profile” of lumbar disc displacement and level-specific cut-off values associated with its development in human. METHODS: 76 volunteers (mean age: 50.6 years; 51.3% males) underwent T2W and T1-rho MRI of the lumbar spine. The degree of disc displacement was assessed at each level based on sagittal T2W MRI. T1-rho values were obtained of each disc. Inter-observer reliability was conducted of all MRI assessments. RESULTS: 380 lumbar discs were assessed. High reliability of imaging measurements was noted. Overall, 50% of the discs had disc displacement, most prevalent at L4-S1. The median T1-rho values for overall lumbar non-displaced discs was 77.6ms compared to 64.5ms for displaced discs (p<0.001). Significant median level-specific and optimal threshold T1-rho values for non-displaced discs vs. displaced discs were identified. DISCUSSION: This is the first study in humans to quantitatively assess the “proteoglycan profile” of lumbar disc displacement. A decrease in proteoglycan concentration on T1-rho MRI was noted in the presence of disc displacement at all disc levels. Level-specific values have been identified that may have predictive utility at the index or adjacent disc levels as well as aid in the classification, etiology and therapeutics of disc displacement.
DescriptionSession: Free Papers - Spine Degenerative I: Abstract no.: 40323
Persistent Identifierhttp://hdl.handle.net/10722/220640

 

DC FieldValueLanguage
dc.contributor.authorSamartzis, D-
dc.contributor.authorPang, H-
dc.contributor.authorHui, SK-
dc.contributor.authorBow, HYC-
dc.contributor.authorCheung, JPY-
dc.contributor.authorBorthakur, A-
dc.contributor.authorKarppinen, JI-
dc.contributor.authorInoue, N-
dc.contributor.authorLuk, KDK-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2015-10-16T06:48:01Z-
dc.date.available2015-10-16T06:48:01Z-
dc.date.issued2015-
dc.identifier.citation36th SICOT Orthopaedic World Congress, Guangzhou, China, 17-19 September 2015-
dc.identifier.urihttp://hdl.handle.net/10722/220640-
dc.descriptionSession: Free Papers - Spine Degenerative I: Abstract no.: 40323-
dc.description.abstractINTRODUCTION: Controversy exists whether disc displacement is associated with disc degeneration, and in vivo proteoglycan concentration of disc displacement is speculative. Signal intensity on T2-weighted (T2W) MRI provides a qualitative snap-shot of disc integrity, but is not reliable and lacks quantification. T1-rho MRI of the discs is shown to quantitatively represent proteoglycan concentration. This imaging study addressed the “proteoglycan profile” of lumbar disc displacement and level-specific cut-off values associated with its development in human. METHODS: 76 volunteers (mean age: 50.6 years; 51.3% males) underwent T2W and T1-rho MRI of the lumbar spine. The degree of disc displacement was assessed at each level based on sagittal T2W MRI. T1-rho values were obtained of each disc. Inter-observer reliability was conducted of all MRI assessments. RESULTS: 380 lumbar discs were assessed. High reliability of imaging measurements was noted. Overall, 50% of the discs had disc displacement, most prevalent at L4-S1. The median T1-rho values for overall lumbar non-displaced discs was 77.6ms compared to 64.5ms for displaced discs (p<0.001). Significant median level-specific and optimal threshold T1-rho values for non-displaced discs vs. displaced discs were identified. DISCUSSION: This is the first study in humans to quantitatively assess the “proteoglycan profile” of lumbar disc displacement. A decrease in proteoglycan concentration on T1-rho MRI was noted in the presence of disc displacement at all disc levels. Level-specific values have been identified that may have predictive utility at the index or adjacent disc levels as well as aid in the classification, etiology and therapeutics of disc displacement.-
dc.languageeng-
dc.publisherSICOT. -
dc.relation.ispartofSICOT Orthopaedic World Congress-
dc.titleT1 rho MRI quantitative proteoglycan profiling of lumbar disc displacement-
dc.typeConference_Paper-
dc.identifier.emailSamartzis, D: dspine@hku.hk-
dc.identifier.emailHui, SK: edshui@hku.hk-
dc.identifier.emailBow, HYC: cbow@hku.hk-
dc.identifier.emailCheung, JPY: cheungjp@hku.hk-
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authoritySamartzis, D=rp01430-
dc.identifier.authorityHui, SK=rp01832-
dc.identifier.authorityCheung, JPY=rp01685-
dc.identifier.authorityLuk, KDK=rp00333-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.hkuros255891-
dc.publisher.placeGuangzhou, China-

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