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Article: EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans

TitleEOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans
Authors
Issue Date2014
Citation
The Journal of Neuroscience, 2014, v. 34 n. 40, p. 13364-13370 How to Cite?
AbstractLearning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity.
Persistent Identifierhttp://hdl.handle.net/10722/220479
ISSN
2015 Impact Factor: 5.924
2015 SCImago Journal Rankings: 5.105
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShen, Y-
dc.contributor.authorZhang, J-
dc.contributor.authorCalarco, JA-
dc.contributor.authorZhang, Y-
dc.date.accessioned2015-10-16T06:43:29Z-
dc.date.available2015-10-16T06:43:29Z-
dc.date.issued2014-
dc.identifier.citationThe Journal of Neuroscience, 2014, v. 34 n. 40, p. 13364-13370-
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10722/220479-
dc.description.abstractLearning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity.-
dc.languageeng-
dc.relation.ispartofThe Journal of Neuroscience-
dc.titleEOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans-
dc.typeArticle-
dc.identifier.emailZhang, J: jzhang1@hku.hk-
dc.identifier.authorityZhang, J=rp01713-
dc.identifier.doi10.1523/jneurosci.0230-14.2014-
dc.identifier.pmcidPMC4180473-
dc.identifier.hkuros255691-
dc.identifier.volume34-
dc.identifier.issue40-
dc.identifier.spage13364-
dc.identifier.epage13370-

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