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Conference Paper: Novel UTE MRI Disc Sign (UDS) and its clinical relevance

TitleNovel UTE MRI Disc Sign (UDS) and its clinical relevance
Authors
Issue Date2015
PublisherSICOT.
Citation
36th SICOT Orthopaedic World Congress, Guangzhou, China, 17-19 September 2015 How to Cite?
AbstractINTRODUCTION: Ultra-short time-to-echo (UTE) MRI assesses short T2 components. Our groupWe identified a new imaging biomarker on UTE - the “UTE Disc Sign (UDS)”. This study aims to assessed the UDS prevalence, association with other MRI phenotypes as well as pain/disability profiles. METHODS: 76 Southern Chinese subjects were recruited (51.3% male; mean age: 50.6 years) for T2W, T1-rho and UTE MRI of the lumbar spine (n=380 discs). T2W MRI was used to assess disc degeneration and other phenotypes, and T1-rho MRI was implemented to obtain quantitative proteoglycan disc profiles. UDS was detected on UTE as a hyper- or hypo-intense band across a disc. Subject demographics, pain and disability profiles were obtained. RESULTS: The UDS was noted in 25% subjects (57.9% males; mean age: 52.6 years). 80% UDS occurred at the lower lumbar levels (L3-S1). 26.3% had multi-level UDS. Subjects with UDS had significantly more disc degeneration, disc displacement, spondylolisthesis, and Modic changes (p<0.001). T1-rho values were lower in UDS discs than non-UDS discs (p=0.022). The majority of UDS could not be detected on T2W MRI. 88% of UDS individuals had LBP. Number of UDS disc levels significantly correlated with worse ODI scores (r=0.303; p=0.013), whereas traditional T2W degenerative grading did not (r=0.234; p=0.057). DISCUSSION: This is the first study to report “UDS” in humans. UDS is a novel imaging biomarker highly associated with spine degeneration and negative clinical profile. UDS serves as a new phenotype that broadens our understanding of degenerative disc changes and may have potential clinical utility.
DescriptionSession: Free Papers Spine Degenerative I: abstract no. 40314
Persistent Identifierhttp://hdl.handle.net/10722/220293

 

DC FieldValueLanguage
dc.contributor.authorSamartzis, D-
dc.contributor.authorPang, H-
dc.contributor.authorHui, ESK-
dc.contributor.authorBow, HYC-
dc.contributor.authorCheung, JPY-
dc.contributor.authorBorthakur, A-
dc.contributor.authorInoue, N-
dc.contributor.authorKarppinen, JI-
dc.contributor.authorWang, HQ-
dc.contributor.authorLuk, KDK-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2015-10-16T06:35:44Z-
dc.date.available2015-10-16T06:35:44Z-
dc.date.issued2015-
dc.identifier.citation36th SICOT Orthopaedic World Congress, Guangzhou, China, 17-19 September 2015-
dc.identifier.urihttp://hdl.handle.net/10722/220293-
dc.descriptionSession: Free Papers Spine Degenerative I: abstract no. 40314-
dc.description.abstractINTRODUCTION: Ultra-short time-to-echo (UTE) MRI assesses short T2 components. Our groupWe identified a new imaging biomarker on UTE - the “UTE Disc Sign (UDS)”. This study aims to assessed the UDS prevalence, association with other MRI phenotypes as well as pain/disability profiles. METHODS: 76 Southern Chinese subjects were recruited (51.3% male; mean age: 50.6 years) for T2W, T1-rho and UTE MRI of the lumbar spine (n=380 discs). T2W MRI was used to assess disc degeneration and other phenotypes, and T1-rho MRI was implemented to obtain quantitative proteoglycan disc profiles. UDS was detected on UTE as a hyper- or hypo-intense band across a disc. Subject demographics, pain and disability profiles were obtained. RESULTS: The UDS was noted in 25% subjects (57.9% males; mean age: 52.6 years). 80% UDS occurred at the lower lumbar levels (L3-S1). 26.3% had multi-level UDS. Subjects with UDS had significantly more disc degeneration, disc displacement, spondylolisthesis, and Modic changes (p<0.001). T1-rho values were lower in UDS discs than non-UDS discs (p=0.022). The majority of UDS could not be detected on T2W MRI. 88% of UDS individuals had LBP. Number of UDS disc levels significantly correlated with worse ODI scores (r=0.303; p=0.013), whereas traditional T2W degenerative grading did not (r=0.234; p=0.057). DISCUSSION: This is the first study to report “UDS” in humans. UDS is a novel imaging biomarker highly associated with spine degeneration and negative clinical profile. UDS serves as a new phenotype that broadens our understanding of degenerative disc changes and may have potential clinical utility.-
dc.languageeng-
dc.publisherSICOT.-
dc.relation.ispartofSICOT Orthopaedic World Congress-
dc.titleNovel UTE MRI Disc Sign (UDS) and its clinical relevance-
dc.typeConference_Paper-
dc.identifier.emailSamartzis, D: dspine@hku.hk-
dc.identifier.emailHui, ESK: edshui@hku.hk-
dc.identifier.emailBow, HYC: cbow@hku.hk-
dc.identifier.emailCheung, JPY: cheungjp@hku.hk-
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authoritySamartzis, D=rp01430-
dc.identifier.authorityHui, ESK=rp01832-
dc.identifier.authorityCheung, JPY=rp01685-
dc.identifier.authorityLuk, KDK=rp00333-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.hkuros255890-
dc.publisher.placeGuangzhou, China-

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