File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Primary cutaneous plasmacytoma: report of two cases and review of the literature

TitlePrimary cutaneous plasmacytoma: report of two cases and review of the literature
Authors
KeywordsAged
Aged, 80 and over
Follow-Up Studies
Humans
Immunoglobulin G/analysis
Immunoglobulin Light Chains/analysis
Immunoglobulin kappa-Chains/analysis
Male
Middle Aged
Plasma Cells/pathology
Plasmacytoma/*pathology
Skin/pathology
Skin Neoplasms/*pathology
Thoracic Neoplasms/*pathology
Issue Date1994
Citation
The American journal of dermatopathology, 1994, v. 16 n. 4, p. 392-397 How to Cite?
AbstractPrimary cutaneous plasmacytomas are very rare. In this report, we describe two such cases and review the literature on this entity. Both patients presented with a slowly growing, painless, and solitary mass on the chest wall. Histologically, one case was composed of mature-looking plasma cells, while the other was composed of immature and anaplastic plasma cells, infiltrating the dermis. The epidermis was spared. Kappa light-chain restriction was demonstrated by immunohistochemical techniques in both cases. There was no evidence of marrow disease even on repeated marrow biopsies, although extracutaneous lesions were detected in one patient. One remained in complete remission 6 years following local irradiation. The other patient was treated with local irradiation and systemic chemotherapy, with a complete response, but this was followed by multiple cutaneous recurrences and further remissions by treatment with cytotoxic agents. The present cases and those reported in the literature illustrate well the variable clinical course of primary cutaneous plasmacytoma. Although cure can apparently be achieved in some patients by local radiation therapy, more than half of the cases relapse or progress to myelomatosis. The disease-related mortality is at least 40%. Thus cutaneous plasmacytoma appears to be more aggressive than noncutaneous extramedullary plasmacytomas and should be separately categorized from them in future studies.
Persistent Identifierhttp://hdl.handle.net/10722/220033
ISSN
2015 Impact Factor: 1.396
2015 SCImago Journal Rankings: 0.632

 

DC FieldValueLanguage
dc.contributor.authorWong, KF-
dc.contributor.authorChan, JK-
dc.contributor.authorLi, LP-
dc.contributor.authorYau, TK-
dc.contributor.authorLee, WMA-
dc.date.accessioned2015-10-16T06:16:34Z-
dc.date.available2015-10-16T06:16:34Z-
dc.date.issued1994-
dc.identifier.citationThe American journal of dermatopathology, 1994, v. 16 n. 4, p. 392-397-
dc.identifier.issn0193-1091-
dc.identifier.urihttp://hdl.handle.net/10722/220033-
dc.description.abstractPrimary cutaneous plasmacytomas are very rare. In this report, we describe two such cases and review the literature on this entity. Both patients presented with a slowly growing, painless, and solitary mass on the chest wall. Histologically, one case was composed of mature-looking plasma cells, while the other was composed of immature and anaplastic plasma cells, infiltrating the dermis. The epidermis was spared. Kappa light-chain restriction was demonstrated by immunohistochemical techniques in both cases. There was no evidence of marrow disease even on repeated marrow biopsies, although extracutaneous lesions were detected in one patient. One remained in complete remission 6 years following local irradiation. The other patient was treated with local irradiation and systemic chemotherapy, with a complete response, but this was followed by multiple cutaneous recurrences and further remissions by treatment with cytotoxic agents. The present cases and those reported in the literature illustrate well the variable clinical course of primary cutaneous plasmacytoma. Although cure can apparently be achieved in some patients by local radiation therapy, more than half of the cases relapse or progress to myelomatosis. The disease-related mortality is at least 40%. Thus cutaneous plasmacytoma appears to be more aggressive than noncutaneous extramedullary plasmacytomas and should be separately categorized from them in future studies.-
dc.languageeng-
dc.relation.ispartofThe American journal of dermatopathology-
dc.subjectAged-
dc.subjectAged, 80 and over-
dc.subjectFollow-Up Studies-
dc.subjectHumans-
dc.subjectImmunoglobulin G/analysis-
dc.subjectImmunoglobulin Light Chains/analysis-
dc.subjectImmunoglobulin kappa-Chains/analysis-
dc.subjectMale-
dc.subjectMiddle Aged-
dc.subjectPlasma Cells/pathology-
dc.subjectPlasmacytoma/*pathology-
dc.subjectSkin/pathology-
dc.subjectSkin Neoplasms/*pathology-
dc.subjectThoracic Neoplasms/*pathology-
dc.titlePrimary cutaneous plasmacytoma: report of two cases and review of the literature-
dc.typeArticle-
dc.identifier.emailLee, WMA: awmlee@hkucc.hku.hk-
dc.identifier.authorityLee, WMA=rp02056-
dc.identifier.pmid7978068-
dc.identifier.hkuros266420-
dc.identifier.volume16-
dc.identifier.issue4-
dc.identifier.spage392-
dc.identifier.epage397-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats