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Article: Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation

TitleAcute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation
Authors
KeywordsAnxiety
Serotonin
Stress hormone
Periaqueductal gray
Hypothalamic-pituitary-adrenal axis
Issue Date2014
Citation
Behavioural Brain Research, 2014, v. 273, p. 155-165 How to Cite?
AbstractSerotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and reciprocal connections with the hypothalamic-pituitary-adrenal (HPA) axis. Although the HPA axis and the 5-HT system are well investigated, the relationship between the stress hormones induced by 5-HT drug treatment and the PAG neural correlates of the behavior remain largely unknown. In this study, the effects of acute and chronic treatments with buspirone (BUSP) and escitalopram (ESCIT) on anxiety-related behaviors were tested in an open-field (OF). The treatment effects on PAG c-Fos immunoreactivity (c-Fos-ir) and corticosterone (CORT) concentration were measured in order to determine the neural-endocrine correlates of anxiety-related behaviors and drug treatments. Our results demonstrate that acute BUSP and ESCIT treatments induced anxiogenic behaviors with elevation of CORT compared to the baseline. A decrease of c-Fos-ir was found in the dorsomedial PAG region of both the treatment groups. Correlation analysis showed that the CORT were not associated with the OF anxiogenic behavior and PAG c-Fos-ir. No significant differences were found in behaviors and CORT after chronic treatment. In conclusion, acute BUSP and ESCIT treatments elicited anxiogenic response with activation of the HPA axis and reduction of c-Fos-ir in the dorsomedial PAG. Although no correlation was found between the stress hormone and the PAG c-Fos-ir, this does not imply the lack of cause-and-effect relationship between neuroendocrine effects and PAG function in anxiety responses. These correlation studies suggest that the regulation of 5-HT system was probably disrupted by acute 5-HT treatment. © 2014 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/219888
ISSN
2015 Impact Factor: 3.002
2015 SCImago Journal Rankings: 1.533

 

DC FieldValueLanguage
dc.contributor.authorHestermann, Dietmar-
dc.contributor.authorTemel, Yasin-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorLim, Lee Wei-
dc.date.accessioned2015-09-24T04:44:16Z-
dc.date.available2015-09-24T04:44:16Z-
dc.date.issued2014-
dc.identifier.citationBehavioural Brain Research, 2014, v. 273, p. 155-165-
dc.identifier.issn0166-4328-
dc.identifier.urihttp://hdl.handle.net/10722/219888-
dc.description.abstractSerotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has robust 5-HT fibers and reciprocal connections with the hypothalamic-pituitary-adrenal (HPA) axis. Although the HPA axis and the 5-HT system are well investigated, the relationship between the stress hormones induced by 5-HT drug treatment and the PAG neural correlates of the behavior remain largely unknown. In this study, the effects of acute and chronic treatments with buspirone (BUSP) and escitalopram (ESCIT) on anxiety-related behaviors were tested in an open-field (OF). The treatment effects on PAG c-Fos immunoreactivity (c-Fos-ir) and corticosterone (CORT) concentration were measured in order to determine the neural-endocrine correlates of anxiety-related behaviors and drug treatments. Our results demonstrate that acute BUSP and ESCIT treatments induced anxiogenic behaviors with elevation of CORT compared to the baseline. A decrease of c-Fos-ir was found in the dorsomedial PAG region of both the treatment groups. Correlation analysis showed that the CORT were not associated with the OF anxiogenic behavior and PAG c-Fos-ir. No significant differences were found in behaviors and CORT after chronic treatment. In conclusion, acute BUSP and ESCIT treatments elicited anxiogenic response with activation of the HPA axis and reduction of c-Fos-ir in the dorsomedial PAG. Although no correlation was found between the stress hormone and the PAG c-Fos-ir, this does not imply the lack of cause-and-effect relationship between neuroendocrine effects and PAG function in anxiety responses. These correlation studies suggest that the regulation of 5-HT system was probably disrupted by acute 5-HT treatment. © 2014 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofBehavioural Brain Research-
dc.subjectAnxiety-
dc.subjectSerotonin-
dc.subjectStress hormone-
dc.subjectPeriaqueductal gray-
dc.subjectHypothalamic-pituitary-adrenal axis-
dc.titleAcute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bbr.2014.07.003-
dc.identifier.pmid25043730-
dc.identifier.scopuseid_2-s2.0-84905962865-
dc.identifier.volume273-
dc.identifier.spage155-
dc.identifier.epage165-
dc.identifier.eissn1872-7549-

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