File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The Periaqueductal Gray: From longitudinal columns to defensive behaviour

TitleThe Periaqueductal Gray: From longitudinal columns to defensive behaviour
Authors
KeywordsPanic disorder
Behaviour
Defensive
Longitudinal columns
Anxiety
Periaqueductal
Issue Date2009
Citation
Ondokuz Mayis Universitesi Tip Dergisi, 2009, v. 26, n. 1, p. 1-26 How to Cite?
AbstractRecent findings on the different functional properties of the neuroanatomical columnar subdivision of the Periaqueductal Gray (PAG) have provided a fundamental understanding for the pathophysiology of panic and anxiety disorder. In this review, we focus mainly on the prominent role of the PAG in defensive behaviour by combining both the behavioural and neuroanatomical data. We have applied the theoretical model of the "two dimensional defence system" by McNaughton and Corr (2004), and thereby constituted an organizational structure on the neuronal circuitry of the different brain regions in relation with this panic-and fearlike behaviour. It has become clear that the dorsal and lateral PAG are involved in the active emotional coping (fight and flight reaction), whereas the ventrolateral PAG is responsible for the passive emotional coping (quiescence/freezing). In this regard, the PAG and other related brain structures are working in concert with different neurotransmitters providing animals with defensive strategies in response to predatory threats. The functional roles of the PAG in these behaviours as characterized in animals warrants further translational studies in humans which may eventually lead to novel approaches in anxiety-and panic-related disorders. © 2009 OMU All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219877
ISSN
2015 SCImago Journal Rankings: 0.106

 

DC FieldValueLanguage
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorBlokland, Arjan-
dc.contributor.authorVisser-Vandewalle, Veerle-
dc.contributor.authorSteinbusch, Harry-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:44:14Z-
dc.date.available2015-09-24T04:44:14Z-
dc.date.issued2009-
dc.identifier.citationOndokuz Mayis Universitesi Tip Dergisi, 2009, v. 26, n. 1, p. 1-26-
dc.identifier.issn1300-2996-
dc.identifier.urihttp://hdl.handle.net/10722/219877-
dc.description.abstractRecent findings on the different functional properties of the neuroanatomical columnar subdivision of the Periaqueductal Gray (PAG) have provided a fundamental understanding for the pathophysiology of panic and anxiety disorder. In this review, we focus mainly on the prominent role of the PAG in defensive behaviour by combining both the behavioural and neuroanatomical data. We have applied the theoretical model of the "two dimensional defence system" by McNaughton and Corr (2004), and thereby constituted an organizational structure on the neuronal circuitry of the different brain regions in relation with this panic-and fearlike behaviour. It has become clear that the dorsal and lateral PAG are involved in the active emotional coping (fight and flight reaction), whereas the ventrolateral PAG is responsible for the passive emotional coping (quiescence/freezing). In this regard, the PAG and other related brain structures are working in concert with different neurotransmitters providing animals with defensive strategies in response to predatory threats. The functional roles of the PAG in these behaviours as characterized in animals warrants further translational studies in humans which may eventually lead to novel approaches in anxiety-and panic-related disorders. © 2009 OMU All rights reserved.-
dc.languageeng-
dc.relation.ispartofOndokuz Mayis Universitesi Tip Dergisi-
dc.subjectPanic disorder-
dc.subjectBehaviour-
dc.subjectDefensive-
dc.subjectLongitudinal columns-
dc.subjectAnxiety-
dc.subjectPeriaqueductal-
dc.titleThe Periaqueductal Gray: From longitudinal columns to defensive behaviour-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-81755188017-
dc.identifier.volume26-
dc.identifier.issue1-
dc.identifier.spage1-
dc.identifier.epage26-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats