File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/nn.2634
- Scopus: eid_2-s2.0-77957275697
- PMID: 20835250
- WOS: WOS:000282171300012
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity
Title | ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity |
---|---|
Authors | |
Issue Date | 2010 |
Citation | Nature Neuroscience, 2010, v. 13, n. 10, p. 1208-1215 How to Cite? |
Abstract | Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. © 2010 Nature America, Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/219863 |
ISSN | 2023 Impact Factor: 21.2 2023 SCImago Journal Rankings: 12.261 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gu, Jiaping | - |
dc.contributor.author | Lee, Chi Wai | - |
dc.contributor.author | Fan, Yanjie | - |
dc.contributor.author | Komlos, Daniel | - |
dc.contributor.author | Tang, Xin | - |
dc.contributor.author | Sun, Chicheng | - |
dc.contributor.author | Yu, Kuai | - |
dc.contributor.author | Hartzell, H. Criss | - |
dc.contributor.author | Chen, Gong | - |
dc.contributor.author | Bamburg, James R. | - |
dc.contributor.author | Zheng, James Q. | - |
dc.date.accessioned | 2015-09-24T04:44:09Z | - |
dc.date.available | 2015-09-24T04:44:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Nature Neuroscience, 2010, v. 13, n. 10, p. 1208-1215 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219863 | - |
dc.description.abstract | Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic potentiation in some cases. Thus, ADF/cofilin may have distinct effects on postsynaptic structure and function. We found that ADF/cofilin-mediated actin dynamics regulated AMPA receptor (AMPAR) trafficking during synaptic potentiation, which was distinct from actin's structural role in spine morphology. Specifically, elevated ADF/cofilin activity markedly enhanced surface addition of AMPARs after chemically induced long-term potentiation (LTP), whereas inhibition of ADF/cofilin abolished AMPAR addition. We found that chemically induced LTP elicited a temporal sequence of ADF/cofilin dephosphorylation and phosphorylation that underlies AMPAR trafficking and spine enlargement. These findings suggest that temporally regulated ADF/cofilin activities function in postsynaptic modifications of receptor number and spine size during synaptic plasticity. © 2010 Nature America, Inc. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Neuroscience | - |
dc.title | ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nn.2634 | - |
dc.identifier.pmid | 20835250 | - |
dc.identifier.scopus | eid_2-s2.0-77957275697 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1208 | - |
dc.identifier.epage | 1215 | - |
dc.identifier.isi | WOS:000282171300012 | - |
dc.identifier.issnl | 1097-6256 | - |