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Article: Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

TitleIncreased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
Authors
KeywordsSubthalamic nucleus
Parkinson's disease
Dorsal raphe nucleus
Serotonin
Issue Date2008
Citation
Brain Research, 2008, v. 1221, p. 93-97 How to Cite?
AbstractSerotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219849
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351

 

DC FieldValueLanguage
dc.contributor.authorKaya, Ahmet H.-
dc.contributor.authorVlamings, Rinske-
dc.contributor.authorTan, Sonny-
dc.contributor.authorLim, Lee Wei-
dc.contributor.authorMagill, Peter J.-
dc.contributor.authorSteinbusch, Harry W M-
dc.contributor.authorVisser-Vandewalle, Veerle-
dc.contributor.authorSharp, Trevor-
dc.contributor.authorTemel, Yasin-
dc.date.accessioned2015-09-24T04:43:49Z-
dc.date.available2015-09-24T04:43:49Z-
dc.date.issued2008-
dc.identifier.citationBrain Research, 2008, v. 1221, p. 93-97-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/10722/219849-
dc.description.abstractSerotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. © 2008 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofBrain Research-
dc.subjectSubthalamic nucleus-
dc.subjectParkinson's disease-
dc.subjectDorsal raphe nucleus-
dc.subjectSerotonin-
dc.titleIncreased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.brainres.2008.05.019-
dc.identifier.pmid18565496-
dc.identifier.scopuseid_2-s2.0-46049108522-
dc.identifier.volume1221-
dc.identifier.spage93-
dc.identifier.epage97-

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