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- Publisher Website: 10.1016/j.brainres.2008.05.019
- Scopus: eid_2-s2.0-46049108522
- PMID: 18565496
- WOS: WOS:000258254300011
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Article: Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
Title | Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats |
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Authors | |
Keywords | Subthalamic nucleus Parkinson's disease Dorsal raphe nucleus Serotonin |
Issue Date | 2008 |
Citation | Brain Research, 2008, v. 1221, p. 93-97 How to Cite? |
Abstract | Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. © 2008 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/219849 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kaya, Ahmet H. | - |
dc.contributor.author | Vlamings, Rinske | - |
dc.contributor.author | Tan, Sonny | - |
dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Magill, Peter J. | - |
dc.contributor.author | Steinbusch, Harry W M | - |
dc.contributor.author | Visser-Vandewalle, Veerle | - |
dc.contributor.author | Sharp, Trevor | - |
dc.contributor.author | Temel, Yasin | - |
dc.date.accessioned | 2015-09-24T04:43:49Z | - |
dc.date.available | 2015-09-24T04:43:49Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Brain Research, 2008, v. 1221, p. 93-97 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219849 | - |
dc.description.abstract | Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain. © 2008 Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Brain Research | - |
dc.subject | Subthalamic nucleus | - |
dc.subject | Parkinson's disease | - |
dc.subject | Dorsal raphe nucleus | - |
dc.subject | Serotonin | - |
dc.title | Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.brainres.2008.05.019 | - |
dc.identifier.pmid | 18565496 | - |
dc.identifier.scopus | eid_2-s2.0-46049108522 | - |
dc.identifier.volume | 1221 | - |
dc.identifier.spage | 93 | - |
dc.identifier.epage | 97 | - |
dc.identifier.isi | WOS:000258254300011 | - |
dc.identifier.issnl | 0006-8993 | - |