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Article: Tricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: Structures, solution behavior and cytotoxicity

TitleTricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: Structures, solution behavior and cytotoxicity
Authors
KeywordsCarbonyl
Cytotoxicity
Electrospray mass spectrometry
Rhenium(1)
Bis(diphenylphosphinomethyl)amine
Issue Date2002
Citation
Journal of Organometallic Chemistry, 2002, v. 650, n. 1-2, p. 123-132 How to Cite?
AbstractModified Mannich reactions of amines, amino acids and a model peptide with Ph2PH and CH2O gave bis(disphenylphosphinomethyl) amines(Ph2PCH2)2NR [R = Ph (1), CH2CH2OH(2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4). CH2COOH (5)] and [ReBr(CO)3(Ph2PCH2)2NCH 2]2 (12). All new complexes have been characterized by NMR and IR spectroscopy and for 7, 9 and 10, single-crystal X-ray diffraction analyses. Electrospray mass spectrometric studies show that the rhenium-phosphine chelates are very stable especially in neutral methanolic solution. Hydrolysis of the ester and amide linkages slowly occur in acidic and basic solutions over several weeks; displacement of the bromide ligand also occurs in basic medium. Cytotoxicity testing of 7-10 and 12 showed that all the complexes are active againts specific tumor cell lines, especially MCF-7 breast cancer and HeLa-S3 suspended eturine carcinoma. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/219459
ISSN
2015 Impact Factor: 2.336
2015 SCImago Journal Rankings: 0.732

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jianyong-
dc.contributor.authorVittal, Jagadese J.-
dc.contributor.authorHenderson, William-
dc.contributor.authorWheaton, Jessica R.-
dc.contributor.authorHall, Iris H.-
dc.contributor.authorHor, T. S Andy-
dc.contributor.authorYan, Yaw Kai-
dc.date.accessioned2015-09-23T02:57:08Z-
dc.date.available2015-09-23T02:57:08Z-
dc.date.issued2002-
dc.identifier.citationJournal of Organometallic Chemistry, 2002, v. 650, n. 1-2, p. 123-132-
dc.identifier.issn0022-328X-
dc.identifier.urihttp://hdl.handle.net/10722/219459-
dc.description.abstractModified Mannich reactions of amines, amino acids and a model peptide with Ph2PH and CH2O gave bis(disphenylphosphinomethyl) amines(Ph2PCH2)2NR [R = Ph (1), CH2CH2OH(2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4). CH2COOH (5)] and [ReBr(CO)3(Ph2PCH2)2NCH 2]2 (12). All new complexes have been characterized by NMR and IR spectroscopy and for 7, 9 and 10, single-crystal X-ray diffraction analyses. Electrospray mass spectrometric studies show that the rhenium-phosphine chelates are very stable especially in neutral methanolic solution. Hydrolysis of the ester and amide linkages slowly occur in acidic and basic solutions over several weeks; displacement of the bromide ligand also occurs in basic medium. Cytotoxicity testing of 7-10 and 12 showed that all the complexes are active againts specific tumor cell lines, especially MCF-7 breast cancer and HeLa-S3 suspended eturine carcinoma. © 2002 Elsevier Science B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Organometallic Chemistry-
dc.subjectCarbonyl-
dc.subjectCytotoxicity-
dc.subjectElectrospray mass spectrometry-
dc.subjectRhenium(1)-
dc.subjectBis(diphenylphosphinomethyl)amine-
dc.titleTricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: Structures, solution behavior and cytotoxicity-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0022-328X(02)01200-7-
dc.identifier.scopuseid_2-s2.0-0036569996-
dc.identifier.volume650-
dc.identifier.issue1-2-
dc.identifier.spage123-
dc.identifier.epage132-

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