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Article: Osteopontin overexpression induced tumor progression and chemoresistance to oxaliplatin through induction of stem-like properties in human colorectal cancer

TitleOsteopontin overexpression induced tumor progression and chemoresistance to oxaliplatin through induction of stem-like properties in human colorectal cancer
Authors
Issue Date2015
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.sage-hindawi.com/journals/sci/
Citation
Stem Cells International, 2015, v. 2015, article no. 247892 How to Cite?
Abstract© 2015 Lui Ng et al.Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. The poor prognosis of colorectal cancer patients is due to development of chemoresistance and cancer metastasis. Recently osteopontin (OPN) has been associated with stem-like properties in colorectal cancer. This study further examined the clinicopathological significance of OPN in CRC and its effect on chemoresistance and transcription of stem cell markers. We examined the transcription level of OPN in 84 CRC patients and correlated the expression with their clinicopathological parameters. The associations of OPN overexpression with transcription of stem cell markers and response to chemotherapy in DLD1-OPN overexpressing clones and CRC patients were also investigated. Our results showed that OPN was significantly overexpressed in CRC, and its overexpression correlated with tumor stage and poor prognosis. Overexpression of CRC induced OCT4 and SOX2 expression in vitro and correlated with SOX2 overexpression in CRC patients. In addition, DLD1-OPN overexpressing cells showed enhanced ability to survive upon oxaliplatin treatment, and OPN expression was higher in CRC patients who were resistant to oxaliplatin-involved chemotherapy treatment. Thus, CRC cells overexpressing OPN demonstrated stem-like properties and OPN inhibition is a potential therapeutic approach to combat CRC progression and chemoresistance.
Persistent Identifierhttp://hdl.handle.net/10722/218910
ISSN
2015 Impact Factor: 3.687
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorNg, L-
dc.contributor.authorWan, TMH-
dc.contributor.authorChow, KM-
dc.contributor.authorLyer, D-
dc.contributor.authorMan, J-
dc.contributor.authorChen, G-
dc.contributor.authorYau, TCC-
dc.contributor.authorLo, OSH-
dc.contributor.authorFoo, CC-
dc.contributor.authorPoon, TCJ-
dc.contributor.authorPoon, RTP-
dc.contributor.authorPang, RWC-
dc.contributor.authorLaw, WL-
dc.date.accessioned2015-09-18T07:00:43Z-
dc.date.available2015-09-18T07:00:43Z-
dc.date.issued2015-
dc.identifier.citationStem Cells International, 2015, v. 2015, article no. 247892-
dc.identifier.issn1687-966X-
dc.identifier.urihttp://hdl.handle.net/10722/218910-
dc.description.abstract© 2015 Lui Ng et al.Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide. The poor prognosis of colorectal cancer patients is due to development of chemoresistance and cancer metastasis. Recently osteopontin (OPN) has been associated with stem-like properties in colorectal cancer. This study further examined the clinicopathological significance of OPN in CRC and its effect on chemoresistance and transcription of stem cell markers. We examined the transcription level of OPN in 84 CRC patients and correlated the expression with their clinicopathological parameters. The associations of OPN overexpression with transcription of stem cell markers and response to chemotherapy in DLD1-OPN overexpressing clones and CRC patients were also investigated. Our results showed that OPN was significantly overexpressed in CRC, and its overexpression correlated with tumor stage and poor prognosis. Overexpression of CRC induced OCT4 and SOX2 expression in vitro and correlated with SOX2 overexpression in CRC patients. In addition, DLD1-OPN overexpressing cells showed enhanced ability to survive upon oxaliplatin treatment, and OPN expression was higher in CRC patients who were resistant to oxaliplatin-involved chemotherapy treatment. Thus, CRC cells overexpressing OPN demonstrated stem-like properties and OPN inhibition is a potential therapeutic approach to combat CRC progression and chemoresistance.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.sage-hindawi.com/journals/sci/-
dc.relation.ispartofStem Cells International-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleOsteopontin overexpression induced tumor progression and chemoresistance to oxaliplatin through induction of stem-like properties in human colorectal cancer-
dc.typeArticle-
dc.identifier.emailNg, L: luing@hku.hk-
dc.identifier.emailChow, KM: chowakm@hku.hk-
dc.identifier.emailChen, G: guanghua@hku.hk-
dc.identifier.emailYau, TCC: tyaucc@hku.hk-
dc.identifier.emailLo, OSH: oswens@hku.hk-
dc.identifier.emailFoo, CC: ccfoo@hku.hk-
dc.identifier.emailPoon, TCJ: tcjensen@hku.hk-
dc.identifier.emailPoon, RTP: poontp@hku.hk-
dc.identifier.emailPang, RWC: robertap@hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.authorityYau, TCC=rp01466-
dc.identifier.authorityFoo, CC=rp01899-
dc.identifier.authorityPoon, TCJ=rp01603-
dc.identifier.authorityPoon, RTP=rp00446-
dc.identifier.authorityPang, RWC=rp00274-
dc.identifier.authorityLaw, WL=rp00436-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2015/247892-
dc.identifier.pmid26106421-
dc.identifier.pmcidPMC4461767-
dc.identifier.scopuseid_2-s2.0-84935888942-
dc.identifier.hkuros254035-
dc.identifier.volume2015-
dc.publisher.placeUnited States-

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