File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.coviro.2015.04.010
- Scopus: eid_2-s2.0-84931268907
- PMID: 26079652
- WOS: WOS:000364797100004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Host genes and influenza pathogenesis in humans: an emerging paradigm
Title | Host genes and influenza pathogenesis in humans: an emerging paradigm |
---|---|
Authors | |
Issue Date | 2015 |
Publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/coviro/ |
Citation | Current Opinion in Virology, 2015, v. 14, p. 7-15 How to Cite? |
Abstract | The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. © 2015 Published by Elsevier B.V. |
Persistent Identifier | http://hdl.handle.net/10722/218774 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.833 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | To, KKW | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Chan, JFW | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2015-09-18T06:52:59Z | - |
dc.date.available | 2015-09-18T06:52:59Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Current Opinion in Virology, 2015, v. 14, p. 7-15 | - |
dc.identifier.issn | 1879-6257 | - |
dc.identifier.uri | http://hdl.handle.net/10722/218774 | - |
dc.description.abstract | The emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. © 2015 Published by Elsevier B.V. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/coviro/ | - |
dc.relation.ispartof | Current Opinion in Virology | - |
dc.rights | Posting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.title | Host genes and influenza pathogenesis in humans: an emerging paradigm | - |
dc.type | Article | - |
dc.identifier.email | To, KKW: kelvinto@hkucc.hku.hk | - |
dc.identifier.email | Zhou, J: jiezhou@hku.hk | - |
dc.identifier.email | Chan, JFW: jfwchan@hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | To, KKW=rp01384 | - |
dc.identifier.authority | Zhou, J=rp01412 | - |
dc.identifier.authority | Chan, JFW=rp01736 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.identifier.doi | 10.1016/j.coviro.2015.04.010 | - |
dc.identifier.pmid | 26079652 | - |
dc.identifier.scopus | eid_2-s2.0-84931268907 | - |
dc.identifier.hkuros | 253225 | - |
dc.identifier.volume | 14 | - |
dc.identifier.spage | 7 | - |
dc.identifier.epage | 15 | - |
dc.identifier.isi | WOS:000364797100004 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1879-6257 | - |