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Article: Host genes and influenza pathogenesis in humans: an emerging paradigm

TitleHost genes and influenza pathogenesis in humans: an emerging paradigm
Authors
Issue Date2015
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/coviro/
Citation
Current Opinion in Virology, 2015, v. 14, p. 7-15 How to Cite?
AbstractThe emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. © 2015 Published by Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/218774
ISSN
2015 Impact Factor: 5.313
2015 SCImago Journal Rankings: 3.135
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTo, KKW-
dc.contributor.authorZhou, J-
dc.contributor.authorChan, JFW-
dc.contributor.authorYuen, KY-
dc.date.accessioned2015-09-18T06:52:59Z-
dc.date.available2015-09-18T06:52:59Z-
dc.date.issued2015-
dc.identifier.citationCurrent Opinion in Virology, 2015, v. 14, p. 7-15-
dc.identifier.issn1879-6257-
dc.identifier.urihttp://hdl.handle.net/10722/218774-
dc.description.abstractThe emergence of the pandemic influenza virus A(H1N1)pdm09 in 2009 and avian influenza virus A(H7N9) in 2013 provided unique opportunities for assessing genetic predispositions to severe disease because many patients did not have any underlying risk factor or neutralizing antibody against these agents, in contrast to seasonal influenza viruses. High-throughput screening platforms and large human or animal databases from international collaborations allow rapid selection of potential candidate genes for confirmatory functional studies. In the last 2 years, at least seven new human susceptibility genes have been identified in genetic association studies. Integration of knowledge from genetic and phenotypic studies is essential to identify important gene targets for treatment and prevention of influenza virus infection. © 2015 Published by Elsevier B.V.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/coviro/-
dc.relation.ispartofCurrent Opinion in Virology-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleHost genes and influenza pathogenesis in humans: an emerging paradigm-
dc.typeArticle-
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hk-
dc.identifier.emailZhou, J: jiezhou@hku.hk-
dc.identifier.emailChan, JFW: jfwchan@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.authorityTo, KKW=rp01384-
dc.identifier.authorityZhou, J=rp01412-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.doi10.1016/j.coviro.2015.04.010-
dc.identifier.pmid26079652-
dc.identifier.scopuseid_2-s2.0-84931268907-
dc.identifier.hkuros253225-
dc.identifier.volume14-
dc.identifier.spage7-
dc.identifier.epage15-
dc.identifier.isiWOS:000364797100004-
dc.publisher.placeUnited Kingdom-

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