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Article: Multiphase Protein Microgels

TitleMultiphase Protein Microgels
Authors
Issue Date2015
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/vch/journals/2127/index.html
Citation
Macromolecular Bioscience, 2015, v. 15 n. 4, p. 501-508 How to Cite?
AbstractPeptides and proteins represent attractive building blocks for the development of new functional materials due to the biocompatibility and biodegradability of many naturally abundant proteins. In nature, sophisticated material functionality is commonly achieved through spatial control of protein localisation and structure on both the nano and micro scales. We approached this requirement in an artificial setting by exploiting the propensity of proteins to self-assemble into amyloid fibrils to achieve nano scale order, and utilised aqueous liquid/liquid phase separation to control the micron scale localization of the proteinaceous component under microconfinement. We show that in combination with droplet microfluidics, this strategy allows the synthesis of core-shell microgel particles composed of protein nanofibrils.
Persistent Identifierhttp://hdl.handle.net/10722/218756
ISSN
2015 Impact Factor: 3.68
2015 SCImago Journal Rankings: 1.257

 

DC FieldValueLanguage
dc.contributor.authorShimanovich, U-
dc.contributor.authorSong, Y-
dc.contributor.authorBrujic, J-
dc.contributor.authorShum, HC-
dc.contributor.authorKnowles, TPJ-
dc.date.accessioned2015-09-18T06:52:32Z-
dc.date.available2015-09-18T06:52:32Z-
dc.date.issued2015-
dc.identifier.citationMacromolecular Bioscience, 2015, v. 15 n. 4, p. 501-508-
dc.identifier.issn1616-5187-
dc.identifier.urihttp://hdl.handle.net/10722/218756-
dc.description.abstractPeptides and proteins represent attractive building blocks for the development of new functional materials due to the biocompatibility and biodegradability of many naturally abundant proteins. In nature, sophisticated material functionality is commonly achieved through spatial control of protein localisation and structure on both the nano and micro scales. We approached this requirement in an artificial setting by exploiting the propensity of proteins to self-assemble into amyloid fibrils to achieve nano scale order, and utilised aqueous liquid/liquid phase separation to control the micron scale localization of the proteinaceous component under microconfinement. We show that in combination with droplet microfluidics, this strategy allows the synthesis of core-shell microgel particles composed of protein nanofibrils.-
dc.languageeng-
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www.wiley-vch.de/vch/journals/2127/index.html-
dc.relation.ispartofMacromolecular Bioscience-
dc.titleMultiphase Protein Microgels-
dc.typeArticle-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439-
dc.identifier.doi10.1002/mabi.201400366-
dc.identifier.pmid25407891-
dc.identifier.hkuros250685-
dc.identifier.volume15-
dc.identifier.issue4-
dc.identifier.spage501-
dc.identifier.epage508-
dc.publisher.placeGermany-

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