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Conference Paper: Matrix metalloproteinase MMP12 is associated with intervertebral disc degeneration

TitleMatrix metalloproteinase MMP12 is associated with intervertebral disc degeneration
Authors
Issue Date2015
Citation
The 2015 Annual Meeting of the the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015. How to Cite?
AbstractINTRODUCTION: Intervertebral disc (IVD) degeneration is associated with low back pain. However, the molecular changes during the degeneration process is not entirely clear. The loss of nucleus pulposus (NP) integrity is one of the early events of the degeneration. Chondrogenic markers, such as SOX9 and aggrecan, have been commonly used to assess the degree of IVD degeneration. Recent transcriptomic studies have proposed several other candidates that may mark IVD degeneration. These include cartilage oligomeric matrix protein (COMP), matrix gla protein (MGP)[1], fibulin 1 (FBLN1) [2], cytokeratin 18 (KRT18) [3], cadherin-2 (CDH2) [3], cytokeratin 19 (KRT19) [2], and Runt-related transcription factor 2 (RUNX2) [4]. Studies also demonstrated that degenerated NP attains a fibrocartilaginous phenotype [5,6] with increased ...
Persistent Identifierhttp://hdl.handle.net/10722/217569

 

DC FieldValueLanguage
dc.contributor.authorLv, F-
dc.contributor.authorLim, FL-
dc.contributor.authorPeng, Y-
dc.contributor.authorSun, Y-
dc.contributor.authorZhou, L-
dc.contributor.authorCheung, K-
dc.contributor.authorLeung, V-
dc.date.accessioned2015-09-18T06:05:06Z-
dc.date.available2015-09-18T06:05:06Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Annual Meeting of the the Orthopaedic Research Society (ORS 2015), Las Vegas, NV., 28-31 March 2015.-
dc.identifier.urihttp://hdl.handle.net/10722/217569-
dc.description.abstractINTRODUCTION: Intervertebral disc (IVD) degeneration is associated with low back pain. However, the molecular changes during the degeneration process is not entirely clear. The loss of nucleus pulposus (NP) integrity is one of the early events of the degeneration. Chondrogenic markers, such as SOX9 and aggrecan, have been commonly used to assess the degree of IVD degeneration. Recent transcriptomic studies have proposed several other candidates that may mark IVD degeneration. These include cartilage oligomeric matrix protein (COMP), matrix gla protein (MGP)[1], fibulin 1 (FBLN1) [2], cytokeratin 18 (KRT18) [3], cadherin-2 (CDH2) [3], cytokeratin 19 (KRT19) [2], and Runt-related transcription factor 2 (RUNX2) [4]. Studies also demonstrated that degenerated NP attains a fibrocartilaginous phenotype [5,6] with increased ...-
dc.languageeng-
dc.relation.ispartofAnnual Meeting of the the Orthopaedic Research Society, ORS 2015-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMatrix metalloproteinase MMP12 is associated with intervertebral disc degeneration-
dc.typeConference_Paper-
dc.identifier.emailLv, F: fengjuan@hku.hk-
dc.identifier.emailLim, FL: foonlian@hku.hk-
dc.identifier.emailCheung, K: cheungmc@hku.hk-
dc.identifier.emailLeung, V: vicleung@hku.hk-
dc.identifier.authorityCheung, K=rp00387-
dc.identifier.authorityLeung, V=rp01764-
dc.description.naturepostprint-
dc.identifier.hkuros250936-

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