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Conference Paper: Investigating the relationship between stroke and serum fatty acids in hypertensive population

TitleInvestigating the relationship between stroke and serum fatty acids in hypertensive population
Authors
KeywordsUSFA
SFA
Stroke
Hypertension
Issue Date2014
PublisherElsevier Inc.. The Journal's web site is located at http://www.ashjournal.com
Citation
The 29th Annual Scientific Meeting of the American Society of Hypertension, New York, NY., 16-20 May 2014. In Journal of the American Society of Hypertension, 2014, v. 8 n. suppl 1, p. e9, abstract no. LB-P-07 How to Cite?
AbstractBACKGROUND: Stroke is prevalent in hypertensive population. It has been suggested that monospecific unsaturated fatty acids (USFA) have potential effect on protection against stroke. However, the effect of saturated fatty acids (SFAs) on stroke is controversial. Therefore, we studied the relationship between recent stroke and serum levels of fatty acids including both USFAs and SFAs in hypertensive patients. METHODS: 89 pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient experiencing a stroke within 48 hours before examination and a hypertensive patient without stroke. 6 categories of serum fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated. Data were analyzed using R version 3.0.1. RESULTS: There were differences in educational level (P¼0.002) and occupation (P<0.001) between stroke and non-stroke participants. Non-stroke participants had higher levels of total cholesterol (P<0.001), triglyceride (P¼0.041), LDL (P¼0.048) and HDL (P¼0.001). All the 6 fatty acid levels were higher in non-stroke participants (P¼0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). Before adjustment, recent stroke was inversely associated with fatty acid levels except lignoceric acid’s. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with recent stroke. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR¼0.965, 95%CI¼0.942-0.990, P¼0.005), behenic acid (OR¼0.778, 95%CI¼0.664-0.939, P¼0.009), nervonic acid (OR¼0.323, 95%CI¼0.121-0.860, P¼0.024) with recent stroke were still highly significant. CONCLUSION: The levels of the fatty acids except lignoceric acid were inversely associated with recent stroke. Our results raise the possibility that both USFAs and SFAs may have beneficial effect on reduction of stroke risk in hypertensive population.
DescriptionLate Breaking Poster Abstract: no. LB-P-07
Persistent Identifierhttp://hdl.handle.net/10722/217540
ISSN
2015 Impact Factor: 2.656
2015 SCImago Journal Rankings: 1.039

 

DC FieldValueLanguage
dc.contributor.authorLI, C-
dc.contributor.authorPeng, H-
dc.contributor.authorCai, XQ-
dc.contributor.authorTsang, TK-
dc.contributor.authorShen, HS-
dc.contributor.authorWu, XH-
dc.contributor.authorZhou, YB-
dc.contributor.authorCheung, BMY-
dc.date.accessioned2015-09-18T06:03:32Z-
dc.date.available2015-09-18T06:03:32Z-
dc.date.issued2014-
dc.identifier.citationThe 29th Annual Scientific Meeting of the American Society of Hypertension, New York, NY., 16-20 May 2014. In Journal of the American Society of Hypertension, 2014, v. 8 n. suppl 1, p. e9, abstract no. LB-P-07-
dc.identifier.issn1933-1711-
dc.identifier.urihttp://hdl.handle.net/10722/217540-
dc.descriptionLate Breaking Poster Abstract: no. LB-P-07-
dc.description.abstractBACKGROUND: Stroke is prevalent in hypertensive population. It has been suggested that monospecific unsaturated fatty acids (USFA) have potential effect on protection against stroke. However, the effect of saturated fatty acids (SFAs) on stroke is controversial. Therefore, we studied the relationship between recent stroke and serum levels of fatty acids including both USFAs and SFAs in hypertensive patients. METHODS: 89 pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient experiencing a stroke within 48 hours before examination and a hypertensive patient without stroke. 6 categories of serum fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated. Data were analyzed using R version 3.0.1. RESULTS: There were differences in educational level (P¼0.002) and occupation (P<0.001) between stroke and non-stroke participants. Non-stroke participants had higher levels of total cholesterol (P<0.001), triglyceride (P¼0.041), LDL (P¼0.048) and HDL (P¼0.001). All the 6 fatty acid levels were higher in non-stroke participants (P¼0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). Before adjustment, recent stroke was inversely associated with fatty acid levels except lignoceric acid’s. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with recent stroke. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR¼0.965, 95%CI¼0.942-0.990, P¼0.005), behenic acid (OR¼0.778, 95%CI¼0.664-0.939, P¼0.009), nervonic acid (OR¼0.323, 95%CI¼0.121-0.860, P¼0.024) with recent stroke were still highly significant. CONCLUSION: The levels of the fatty acids except lignoceric acid were inversely associated with recent stroke. Our results raise the possibility that both USFAs and SFAs may have beneficial effect on reduction of stroke risk in hypertensive population.-
dc.languageeng-
dc.publisherElsevier Inc.. The Journal's web site is located at http://www.ashjournal.com-
dc.relation.ispartofAmerican Society of Hypertension. Journal-
dc.rights© <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectUSFA-
dc.subjectSFA-
dc.subjectStroke-
dc.subjectHypertension-
dc.titleInvestigating the relationship between stroke and serum fatty acids in hypertensive population-
dc.typeConference_Paper-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.doi10.1016/j.jash.2014.07.021-
dc.identifier.hkuros254016-
dc.identifier.volume8-
dc.identifier.issuesuppl 1-
dc.identifier.spagee9, abstract no. LB-
dc.identifier.epageP-
dc.publisher.placeUnited States-

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