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Article: A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation

TitleA detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation
Authors
Issue Date2016
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/09145087
Citation
Journal of Cardiology, 2016, v. 67 n. 1-2, p. 140-146 How to Cite?
AbstractBackground: Cirrhosis has been shown to be associated with left ventricular (LV) myocardial dysfunction, but studies of right ventricular (RV) function in cirrhotic patients compared with controls are scarce. Limited studies have prospectively evaluated the progression of myocardial function in patients with cirrhosis and assessed changes in cardiac function following liver transplantation (LTx). So the aim of the study was to evaluate biventricular myocardial function in cirrhotic patients and its alteration with or without liver transplantation. Methods: A total of 103 patients with cirrhosis (age 55 ± 7 years, male 75%) were recruited. Conventional and 2-dimensional speckle tracking echocardiography was performed to determine the presence of LV and RV (biventricular) dysfunction. For comparison, 48 matched control subjects were included. Follow-up echocardiography was performed in 41 patients following LTx and in 26 patients who did not undergo LTx. Results: Patients with cirrhosis had biventricular dilatation, increased LV mass, impaired LV diastolic function, and biventricular systolic strain compared with controls. Following LTx, cirrhotic patients had reduced biventricular dilatation, a smaller LV mass, and improved biventricular systolic strain after a mean duration of 18.2 ± 6.6 months. Patients who did not undergo LTx had a further increase in LV mass but no significant change in biventricular dimensions or systolic strain (mean duration of 20.4 ± 8.3 months). Conclusions: The present study demonstrates that patients with cirrhosis had biventricular dilatation and impaired biventricular systolic strain compared with controls. Following LTx, biventricular dilatation reduced and biventricular systolic strain improved. In contrast, patients who did not undergo LTx experienced a further increase in LV mass. © 2015 Japanese College of Cardiology.
Persistent Identifierhttp://hdl.handle.net/10722/217181
ISSN
2015 Impact Factor: 2.405
2015 SCImago Journal Rankings: 0.972
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Y-
dc.contributor.authorChan, ACY-
dc.contributor.authorChan, SC-
dc.contributor.authorChok, KSH-
dc.contributor.authorSharr, WW-
dc.contributor.authorFung, JYY-
dc.contributor.authorLiu, JH-
dc.contributor.authorZhen, Z-
dc.contributor.authorSin, WC-
dc.contributor.authorLo, CM-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2015-09-18T05:51:08Z-
dc.date.available2015-09-18T05:51:08Z-
dc.date.issued2016-
dc.identifier.citationJournal of Cardiology, 2016, v. 67 n. 1-2, p. 140-146-
dc.identifier.issn0914-5087-
dc.identifier.urihttp://hdl.handle.net/10722/217181-
dc.description.abstractBackground: Cirrhosis has been shown to be associated with left ventricular (LV) myocardial dysfunction, but studies of right ventricular (RV) function in cirrhotic patients compared with controls are scarce. Limited studies have prospectively evaluated the progression of myocardial function in patients with cirrhosis and assessed changes in cardiac function following liver transplantation (LTx). So the aim of the study was to evaluate biventricular myocardial function in cirrhotic patients and its alteration with or without liver transplantation. Methods: A total of 103 patients with cirrhosis (age 55 ± 7 years, male 75%) were recruited. Conventional and 2-dimensional speckle tracking echocardiography was performed to determine the presence of LV and RV (biventricular) dysfunction. For comparison, 48 matched control subjects were included. Follow-up echocardiography was performed in 41 patients following LTx and in 26 patients who did not undergo LTx. Results: Patients with cirrhosis had biventricular dilatation, increased LV mass, impaired LV diastolic function, and biventricular systolic strain compared with controls. Following LTx, cirrhotic patients had reduced biventricular dilatation, a smaller LV mass, and improved biventricular systolic strain after a mean duration of 18.2 ± 6.6 months. Patients who did not undergo LTx had a further increase in LV mass but no significant change in biventricular dimensions or systolic strain (mean duration of 20.4 ± 8.3 months). Conclusions: The present study demonstrates that patients with cirrhosis had biventricular dilatation and impaired biventricular systolic strain compared with controls. Following LTx, biventricular dilatation reduced and biventricular systolic strain improved. In contrast, patients who did not undergo LTx experienced a further increase in LV mass. © 2015 Japanese College of Cardiology.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/issn/09145087-
dc.relation.ispartofJournal of Cardiology-
dc.titleA detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation-
dc.typeArticle-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailSharr, WW: wwsharr@hku.hk-
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hk-
dc.identifier.emailLiu, JH: liujuhua@hku.hk-
dc.identifier.emailSin, WC: drwcsin@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.doi10.1016/j.jjcc.2015.08.001-
dc.identifier.pmid26304615-
dc.identifier.scopuseid_2-s2.0-84955305225-
dc.identifier.hkuros254788-
dc.identifier.volume67-
dc.identifier.issue1-2-
dc.identifier.spage140-
dc.identifier.epage146-
dc.identifier.isiWOS:000370212100026-
dc.publisher.placeNetherlands-

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