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Article: Effect of the addition of a labile gelatin component on the degradation and solute release kinetics of a stable peg hydrogel

TitleEffect of the addition of a labile gelatin component on the degradation and solute release kinetics of a stable peg hydrogel
Authors
KeywordsSemi-interpenetrating polymer network (sIPN)
Degradation
Delivery vehicle
Poly(ethylene glycol)
Hydrogel
Gelatin
Issue Date2012
Citation
Journal of Biomaterials Science, Polymer Edition, 2012, v. 23, n. 12, p. 1595-1611 How to Cite?
AbstractCharacterization of the degradation mechanisms and resulting products of biodegradable materials is critical in understanding the behavior of the material including solute transport and biological response. Previous mathematical analyses of a semi-interpenetrating network (sIPN) containing both labile gelatin and a stable cross-linked poly(ethylene glycol) (PEG) network found that diffusion-based models alone were unable to explain the release kinetics of solutes from the system. In this study, degradation of the sIPN and its effect on solute release and swelling kinetics were investigated. The kinetics of the primary mode of degradation, gelatin dissolution, was dependent on temperature, preparation methods, PEGdA and gelatin concentration, and the weight ratio between the gelatin and PEG. The gelatin dissolution rate positively correlated with both matrix swelling and the release kinetics of high-molecular-weight model compound, FITC-dextran. Coupled with previous in vitro studies, the kinetics of sIPN degradation provided insights into the time-dependent changes in cellular response including adhesion and protein expression. These results provide a facile guide in material formulation to control the delivery of high-molecular-weight compounds with concomitant modulation of cellular behavior. © 2011 Koninklijke Brill NV, Leiden.
Persistent Identifierhttp://hdl.handle.net/10722/216220
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.482

 

DC FieldValueLanguage
dc.contributor.authorWaldeck, H.-
dc.contributor.authorKao, W. J.-
dc.date.accessioned2015-08-25T10:22:34Z-
dc.date.available2015-08-25T10:22:34Z-
dc.date.issued2012-
dc.identifier.citationJournal of Biomaterials Science, Polymer Edition, 2012, v. 23, n. 12, p. 1595-1611-
dc.identifier.issn0920-5063-
dc.identifier.urihttp://hdl.handle.net/10722/216220-
dc.description.abstractCharacterization of the degradation mechanisms and resulting products of biodegradable materials is critical in understanding the behavior of the material including solute transport and biological response. Previous mathematical analyses of a semi-interpenetrating network (sIPN) containing both labile gelatin and a stable cross-linked poly(ethylene glycol) (PEG) network found that diffusion-based models alone were unable to explain the release kinetics of solutes from the system. In this study, degradation of the sIPN and its effect on solute release and swelling kinetics were investigated. The kinetics of the primary mode of degradation, gelatin dissolution, was dependent on temperature, preparation methods, PEGdA and gelatin concentration, and the weight ratio between the gelatin and PEG. The gelatin dissolution rate positively correlated with both matrix swelling and the release kinetics of high-molecular-weight model compound, FITC-dextran. Coupled with previous in vitro studies, the kinetics of sIPN degradation provided insights into the time-dependent changes in cellular response including adhesion and protein expression. These results provide a facile guide in material formulation to control the delivery of high-molecular-weight compounds with concomitant modulation of cellular behavior. © 2011 Koninklijke Brill NV, Leiden.-
dc.languageeng-
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition-
dc.subjectSemi-interpenetrating polymer network (sIPN)-
dc.subjectDegradation-
dc.subjectDelivery vehicle-
dc.subjectPoly(ethylene glycol)-
dc.subjectHydrogel-
dc.subjectGelatin-
dc.titleEffect of the addition of a labile gelatin component on the degradation and solute release kinetics of a stable peg hydrogel-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1163/092050611X587547-
dc.identifier.scopuseid_2-s2.0-84867219207-
dc.identifier.volume23-
dc.identifier.issue12-
dc.identifier.spage1595-
dc.identifier.epage1611-
dc.identifier.eissn1568-5624-

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