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Article: Extracellular matrix-derived tripeptide proline-glycine-proline inhibits keratinocyte proliferation and migration

TitleExtracellular matrix-derived tripeptide proline-glycine-proline inhibits keratinocyte proliferation and migration
Authors
Issue Date2011
Citation
Wound Repair and Regeneration, 2011, v. 19, n. 6, p. 718-726 How to Cite?
AbstractKeratinocytes are the predominant cell type in epidermis, and are primarily responsible for the epithelialization phase of wound healing. Previous studies by our group showed a positive correlation between IL-8 concentration and delayed healing of porcine cutaneous partial-thickness wounds. Interleukin-8 and collagen-breakdown product N-acetyl-Pro-Gly-Pro (PGP) are known as chemoattractant molecules for neutrophils during inflammation. The activity of both molecules is dependent on chemokine receptors CXCR1 and CXCR2. In addition to neutrophils, keratinocytes also express CXCR1 and CXCR2. Here we investigated the effects of IL-8 and PGP on keratinocyte proliferation and migration. Our results showed that IL-8 up to 100ng/mL does not have any significant impact on keratinocyte proliferation or migration. ECM-derived tripeptide PGP chemotactically attracts neutrophils but not keratinocytes. PGP strongly inhibits keratinocyte proliferation and migration in a cell-type specific manner. Thus, collagen breakdown product PGP plays a key role in modulating both the inflammatory and epithelialization phases of wound healing. © 2011 by the Wound Healing Society.
Persistent Identifierhttp://hdl.handle.net/10722/216211
ISSN
2015 Impact Factor: 2.628
2015 SCImago Journal Rankings: 1.149

 

DC FieldValueLanguage
dc.contributor.authorMa, Yiwei-
dc.contributor.authorKleinbeck, Kyle-
dc.contributor.authorKao, W. John-
dc.date.accessioned2015-08-25T10:22:29Z-
dc.date.available2015-08-25T10:22:29Z-
dc.date.issued2011-
dc.identifier.citationWound Repair and Regeneration, 2011, v. 19, n. 6, p. 718-726-
dc.identifier.issn1067-1927-
dc.identifier.urihttp://hdl.handle.net/10722/216211-
dc.description.abstractKeratinocytes are the predominant cell type in epidermis, and are primarily responsible for the epithelialization phase of wound healing. Previous studies by our group showed a positive correlation between IL-8 concentration and delayed healing of porcine cutaneous partial-thickness wounds. Interleukin-8 and collagen-breakdown product N-acetyl-Pro-Gly-Pro (PGP) are known as chemoattractant molecules for neutrophils during inflammation. The activity of both molecules is dependent on chemokine receptors CXCR1 and CXCR2. In addition to neutrophils, keratinocytes also express CXCR1 and CXCR2. Here we investigated the effects of IL-8 and PGP on keratinocyte proliferation and migration. Our results showed that IL-8 up to 100ng/mL does not have any significant impact on keratinocyte proliferation or migration. ECM-derived tripeptide PGP chemotactically attracts neutrophils but not keratinocytes. PGP strongly inhibits keratinocyte proliferation and migration in a cell-type specific manner. Thus, collagen breakdown product PGP plays a key role in modulating both the inflammatory and epithelialization phases of wound healing. © 2011 by the Wound Healing Society.-
dc.languageeng-
dc.relation.ispartofWound Repair and Regeneration-
dc.titleExtracellular matrix-derived tripeptide proline-glycine-proline inhibits keratinocyte proliferation and migration-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1524-475X.2011.00734.x-
dc.identifier.pmid22092842-
dc.identifier.scopuseid_2-s2.0-80155141655-
dc.identifier.volume19-
dc.identifier.issue6-
dc.identifier.spage718-
dc.identifier.epage726-
dc.identifier.eissn1524-475X-

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