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Article: Biomaterials modulate interleukin-8 and other inflammatory proteins during reepithelialization in cutaneous partial-thickness wounds in pigs

TitleBiomaterials modulate interleukin-8 and other inflammatory proteins during reepithelialization in cutaneous partial-thickness wounds in pigs
Authors
Issue Date2010
Citation
Wound Repair and Regeneration, 2010, v. 18, n. 5, p. 486-498 How to Cite?
AbstractAcute and chronic cutaneous wounds remain a clinical challenge that require a mechanistic understanding to advance treatment options. For example, the role of inflammatory mediators during wound healing is not completely understood. Biomimetic materials, such as an in situ photopolymerizable semi- interpenetrating network (sIPN) derived from extracellular matrix components, show great potential in improving healing through the delivery of therapeutic agents and the function as a temporary tissue scaffold. In this study, we characterized the temporal profile of porcine cutaneous partial-thickness wound healing in response to Xeroform ™ and sIPN treatment via histological and inflammatory protein analyses in epidermal, remodeling dermal, and dermal regions. Generally, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, interferon-γ, and tumor necrosis factor-α, but not IL-8, were expressed in the epidermis and remodeling dermis in a time course that followed the progression of epidermal maturation in response to both treatments. Differences in cellularity and protein expression were observed between treatments in a time- and region-dependent manner. In particular, the healing response to sIPN exemplified a potentially key relationship between IL-8 expression and reepithelialization. These results provide insights into the expression of inflammatory mediators and the time course of cutaneous healing and the capacity for biomaterials to further modulate this relationship. © 2010 by the Wound Healing Society.
Persistent Identifierhttp://hdl.handle.net/10722/216207
ISSN
2015 Impact Factor: 2.628
2015 SCImago Journal Rankings: 1.149

 

DC FieldValueLanguage
dc.contributor.authorKleinbeck, Kyle R.-
dc.contributor.authorFaucher, Lee D.-
dc.contributor.authorKao, Weiyuan J.-
dc.date.accessioned2015-08-25T10:22:26Z-
dc.date.available2015-08-25T10:22:26Z-
dc.date.issued2010-
dc.identifier.citationWound Repair and Regeneration, 2010, v. 18, n. 5, p. 486-498-
dc.identifier.issn1067-1927-
dc.identifier.urihttp://hdl.handle.net/10722/216207-
dc.description.abstractAcute and chronic cutaneous wounds remain a clinical challenge that require a mechanistic understanding to advance treatment options. For example, the role of inflammatory mediators during wound healing is not completely understood. Biomimetic materials, such as an in situ photopolymerizable semi- interpenetrating network (sIPN) derived from extracellular matrix components, show great potential in improving healing through the delivery of therapeutic agents and the function as a temporary tissue scaffold. In this study, we characterized the temporal profile of porcine cutaneous partial-thickness wound healing in response to Xeroform ™ and sIPN treatment via histological and inflammatory protein analyses in epidermal, remodeling dermal, and dermal regions. Generally, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-10, IL-12p70, interferon-γ, and tumor necrosis factor-α, but not IL-8, were expressed in the epidermis and remodeling dermis in a time course that followed the progression of epidermal maturation in response to both treatments. Differences in cellularity and protein expression were observed between treatments in a time- and region-dependent manner. In particular, the healing response to sIPN exemplified a potentially key relationship between IL-8 expression and reepithelialization. These results provide insights into the expression of inflammatory mediators and the time course of cutaneous healing and the capacity for biomaterials to further modulate this relationship. © 2010 by the Wound Healing Society.-
dc.languageeng-
dc.relation.ispartofWound Repair and Regeneration-
dc.titleBiomaterials modulate interleukin-8 and other inflammatory proteins during reepithelialization in cutaneous partial-thickness wounds in pigs-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1524-475X.2010.00609.x-
dc.identifier.pmid20731797-
dc.identifier.scopuseid_2-s2.0-77956622664-
dc.identifier.volume18-
dc.identifier.issue5-
dc.identifier.spage486-
dc.identifier.epage498-
dc.identifier.eissn1524-475X-

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