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- Publisher Website: 10.1016/j.biomaterials.2006.08.041
- Scopus: eid_2-s2.0-33750146181
- PMID: 16978691
- WOS: WOS:000242960900001
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Article: The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
Title | The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function |
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Authors | |
Keywords | Inflammation Cytokine Alveolar macrophage Tyrosine phosphorylation RGD PHSRN Monocyte |
Issue Date | 2007 |
Citation | Biomaterials, 2007, v. 28, n. 3, p. 371-382 How to Cite? |
Abstract | Macrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function. © 2006 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/216186 |
ISSN | 2023 Impact Factor: 12.8 2023 SCImago Journal Rankings: 3.016 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schmidt, David Richard | - |
dc.contributor.author | Kao, Weiyuan John | - |
dc.date.accessioned | 2015-08-25T10:22:17Z | - |
dc.date.available | 2015-08-25T10:22:17Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Biomaterials, 2007, v. 28, n. 3, p. 371-382 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10722/216186 | - |
dc.description.abstract | Macrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function. © 2006 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Biomaterials | - |
dc.subject | Inflammation | - |
dc.subject | Cytokine | - |
dc.subject | Alveolar macrophage | - |
dc.subject | Tyrosine phosphorylation | - |
dc.subject | RGD | - |
dc.subject | PHSRN | - |
dc.subject | Monocyte | - |
dc.title | The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.biomaterials.2006.08.041 | - |
dc.identifier.pmid | 16978691 | - |
dc.identifier.scopus | eid_2-s2.0-33750146181 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 371 | - |
dc.identifier.epage | 382 | - |
dc.identifier.isi | WOS:000242960900001 | - |
dc.identifier.issnl | 0142-9612 | - |