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Article: The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function

TitleThe interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function
Authors
KeywordsInflammation
Cytokine
Alveolar macrophage
Tyrosine phosphorylation
RGD
PHSRN
Monocyte
Issue Date2007
Citation
Biomaterials, 2007, v. 28, n. 3, p. 371-382 How to Cite?
AbstractMacrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/216186
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565

 

DC FieldValueLanguage
dc.contributor.authorSchmidt, David Richard-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:22:17Z-
dc.date.available2015-08-25T10:22:17Z-
dc.date.issued2007-
dc.identifier.citationBiomaterials, 2007, v. 28, n. 3, p. 371-382-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/216186-
dc.description.abstractMacrophages play a critical role in mediating the host response to biomaterials, perhaps most notably by guiding the host inflammatory response through the release of inflammatory molecules such as the cytokine interleukin-1 (IL-1). The extent of the macrophage response following interaction with the biomaterial surface contributes greatly to device efficacy, yet the molecular mechanisms of this interaction are still unclear. The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular adhesion and tissue integration. Macrophage interaction with FN and other ECM molecules on the biomaterial surface has been shown to induce a variety of inflammatory responses, thus both FN and IL-1 can be utilized as model molecules to better understand the mechanisms of material-mediated macrophage responses. This literature review presents a comprehensive survey of past and current research on the interrelated role of IL-1, FN, and FN-derivatives in determining biomaterial-modulated macrophage function. © 2006 Elsevier Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofBiomaterials-
dc.subjectInflammation-
dc.subjectCytokine-
dc.subjectAlveolar macrophage-
dc.subjectTyrosine phosphorylation-
dc.subjectRGD-
dc.subjectPHSRN-
dc.subjectMonocyte-
dc.titleThe interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2006.08.041-
dc.identifier.pmid16978691-
dc.identifier.scopuseid_2-s2.0-33750146181-
dc.identifier.volume28-
dc.identifier.issue3-
dc.identifier.spage371-
dc.identifier.epage382-

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