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Conference Paper: Phosphotyrosine protein activation and identification in adherent U-937 macrophages mediated by Fibronectin Domains

TitlePhosphotyrosine protein activation and identification in adherent U-937 macrophages mediated by Fibronectin Domains
Authors
Issue Date2004
Citation
Transactions - 7th World Biomaterials Congress, 2004, p. 425 How to Cite?
AbstractFibronectin (FN)-derived oligopeptides were developed to probe the molecular mechanisms of ligand-receptor binding, post-ligation intracellular signalling and phenotypic expression of human macrophages. The baseline adhesion kinetics of U-937 was established and utilized to maximize the amount of intracellular proteins that could be collected and analyzed. Time points up to 24 h were chosen to minimize the contribution of post-adhesion cell proliferation and/or phenotype changes as not to askew the ligand-mediated adhesion result and the subsequent analyses. The identification of these proteins provide insights into the critical modulatory factors in monocyte-surface interactions.
Persistent Identifierhttp://hdl.handle.net/10722/216176

 

DC FieldValueLanguage
dc.contributor.authorChen, X. X.-
dc.contributor.authorZukermman, S.-
dc.contributor.authorLi, J.-
dc.contributor.authorWitte, R. P.-
dc.contributor.authorPhillips, J. M.-
dc.contributor.authorKao, W. J.-
dc.date.accessioned2015-08-25T10:22:12Z-
dc.date.available2015-08-25T10:22:12Z-
dc.date.issued2004-
dc.identifier.citationTransactions - 7th World Biomaterials Congress, 2004, p. 425-
dc.identifier.urihttp://hdl.handle.net/10722/216176-
dc.description.abstractFibronectin (FN)-derived oligopeptides were developed to probe the molecular mechanisms of ligand-receptor binding, post-ligation intracellular signalling and phenotypic expression of human macrophages. The baseline adhesion kinetics of U-937 was established and utilized to maximize the amount of intracellular proteins that could be collected and analyzed. Time points up to 24 h were chosen to minimize the contribution of post-adhesion cell proliferation and/or phenotype changes as not to askew the ligand-mediated adhesion result and the subsequent analyses. The identification of these proteins provide insights into the critical modulatory factors in monocyte-surface interactions.-
dc.languageeng-
dc.relation.ispartofTransactions - 7th World Biomaterials Congress-
dc.titlePhosphotyrosine protein activation and identification in adherent U-937 macrophages mediated by Fibronectin Domains-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-13844297104-
dc.identifier.spage425-
dc.identifier.epage425-

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