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Conference Paper: Intracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-substrate interaction

TitleIntracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-substrate interaction
Authors
KeywordsPHSRN
RGD
Fibronectin
Protein kinase
Host foreign-body reaction
Issue Date2002
Citation
Journal of Biomedical Materials Research, 2002, v. 62, n. 4, p. 478-487 How to Cite?
AbstractFibronectin and RGD- and/or PHSRN-containing oligopeptides were preadsorbed onto physicochemically distinct substrata: polyethyleneglycol-based networks or tissue culture polystyrene (TCPS). The role of selected signaling kinases (namely protein tyrosine kinases, protein serine/threonine kinases, PI3-kinase, Src, and MAPK) in the adhesion of human primary blood-derived macrophages and the formation of foreign-body giant cells (FBGC) on these modified substrata was investigated. The involvement of individual intracellular signaling molecules in mediating macrophage adhesion dynamically varied with the culture time, substrate, and ligand. For example, fibronectin on TCPS or networks involved similar signaling events for macrophage adhesion; however, fibronectin and G3RGDG6PHSRNG, but not peptides with other RGD and/or PHSRN orientations, mediated similar signaling events for macrophage adhesion on TCPS but mediated different signaling events on networks. Depending on the substrate, a specific molecule (i.e., Src, protein kinase C) within the protein tyrosine kinase or protein serine/threonine kinase family was either an antagonist or agonist in mediating FBGC formation. © 2002 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/216163
ISSN
2004 Impact Factor: 3.652
2006 SCImago Journal Rankings: 0.474

 

DC FieldValueLanguage
dc.contributor.authorKao, Weiyuan John-
dc.contributor.authorLiu, Yiping-
dc.date.accessioned2015-08-25T10:22:06Z-
dc.date.available2015-08-25T10:22:06Z-
dc.date.issued2002-
dc.identifier.citationJournal of Biomedical Materials Research, 2002, v. 62, n. 4, p. 478-487-
dc.identifier.issn0021-9304-
dc.identifier.urihttp://hdl.handle.net/10722/216163-
dc.description.abstractFibronectin and RGD- and/or PHSRN-containing oligopeptides were preadsorbed onto physicochemically distinct substrata: polyethyleneglycol-based networks or tissue culture polystyrene (TCPS). The role of selected signaling kinases (namely protein tyrosine kinases, protein serine/threonine kinases, PI3-kinase, Src, and MAPK) in the adhesion of human primary blood-derived macrophages and the formation of foreign-body giant cells (FBGC) on these modified substrata was investigated. The involvement of individual intracellular signaling molecules in mediating macrophage adhesion dynamically varied with the culture time, substrate, and ligand. For example, fibronectin on TCPS or networks involved similar signaling events for macrophage adhesion; however, fibronectin and G3RGDG6PHSRNG, but not peptides with other RGD and/or PHSRN orientations, mediated similar signaling events for macrophage adhesion on TCPS but mediated different signaling events on networks. Depending on the substrate, a specific molecule (i.e., Src, protein kinase C) within the protein tyrosine kinase or protein serine/threonine kinase family was either an antagonist or agonist in mediating FBGC formation. © 2002 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofJournal of Biomedical Materials Research-
dc.subjectPHSRN-
dc.subjectRGD-
dc.subjectFibronectin-
dc.subjectProtein kinase-
dc.subjectHost foreign-body reaction-
dc.titleIntracellular signaling involved in macrophage adhesion and FBGC formation as mediated by ligand-substrate interaction-
dc.typeConference_Paper-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.10317-
dc.identifier.pmid12378693-
dc.identifier.scopuseid_2-s2.0-0037114252-
dc.identifier.volume62-
dc.identifier.issue4-
dc.identifier.spage478-
dc.identifier.epage487-

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