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Article: Preparation of heterodifunctional polyethyleneglycols: Network formation, characterization, and cell culture analysis

TitlePreparation of heterodifunctional polyethyleneglycols: Network formation, characterization, and cell culture analysis
Authors
KeywordsPolymers
Synthesis
Hydrophilicity
Fibroblasts
Biomaterials
Issue Date2001
Citation
Journal of Biomaterials Science, Polymer Edition, 2001, v. 12, n. 6, p. 599-611 How to Cite?
AbstractPolyethyleneglycols (PEG) are employed extensively in the development of biomaterials; however, the hydroxyl groups in PEG-diols have very limited chemical activity. We developed a synthesis scheme for a library of heterodifunctional PEG (hPEG) with two distinct terminal moieties to improve the reactivity and physicochemical properties of PEG. hPEG were employed in the formulation of polymer networks with various surface physicochemical properties and utilized to study cell-material interaction. Extensive NMR and HPLC analyses confirmed the chemical structure of hPEG. The hydrophilicity of the polymer network was predominantly dependent on the hPEG concentration with the molecular weight and terminal functional group playing lesser roles. Adherent human fibroblast density on the network remained constant with increasing hPEG concentration in the network formulation but decreased rapidly on networks containing 0.8-1.25 g ml-1 of hPEG. This trend was independent of the hPEG terminal moiety and molecular weight. No adherent cell was observed on all films containing 2.5 g ml-1 or more of hPEG.
Persistent Identifierhttp://hdl.handle.net/10722/216158
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.482

 

DC FieldValueLanguage
dc.contributor.authorKao, Weiyuan John-
dc.contributor.authorLok, David-
dc.contributor.authorLi, Jing-
dc.date.accessioned2015-08-25T10:22:04Z-
dc.date.available2015-08-25T10:22:04Z-
dc.date.issued2001-
dc.identifier.citationJournal of Biomaterials Science, Polymer Edition, 2001, v. 12, n. 6, p. 599-611-
dc.identifier.issn0920-5063-
dc.identifier.urihttp://hdl.handle.net/10722/216158-
dc.description.abstractPolyethyleneglycols (PEG) are employed extensively in the development of biomaterials; however, the hydroxyl groups in PEG-diols have very limited chemical activity. We developed a synthesis scheme for a library of heterodifunctional PEG (hPEG) with two distinct terminal moieties to improve the reactivity and physicochemical properties of PEG. hPEG were employed in the formulation of polymer networks with various surface physicochemical properties and utilized to study cell-material interaction. Extensive NMR and HPLC analyses confirmed the chemical structure of hPEG. The hydrophilicity of the polymer network was predominantly dependent on the hPEG concentration with the molecular weight and terminal functional group playing lesser roles. Adherent human fibroblast density on the network remained constant with increasing hPEG concentration in the network formulation but decreased rapidly on networks containing 0.8-1.25 g ml-1 of hPEG. This trend was independent of the hPEG terminal moiety and molecular weight. No adherent cell was observed on all films containing 2.5 g ml-1 or more of hPEG.-
dc.languageeng-
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition-
dc.subjectPolymers-
dc.subjectSynthesis-
dc.subjectHydrophilicity-
dc.subjectFibroblasts-
dc.subjectBiomaterials-
dc.titlePreparation of heterodifunctional polyethyleneglycols: Network formation, characterization, and cell culture analysis-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1163/156856201316883430-
dc.identifier.pmid11556739-
dc.identifier.scopuseid_2-s2.0-0034857153-
dc.identifier.volume12-
dc.identifier.issue6-
dc.identifier.spage599-
dc.identifier.epage611-

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