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Article: Cell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype

TitleCell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype
Authors
KeywordsMultipotential differentiation
Mesenchymal stem cells
Cell biology
Monocyte
Issue Date2012
Citation
Stem Cells Translational Medicine, 2012, v. 1, n. 10, p. 740-749 How to Cite?
AbstractBone marrow mesenchymal stromal/stem cell (MSC) encapsulation within a biomatrix could improve cellular delivery and extend survival and residence time over conventional intravenous administration. Although MSCs modulate monocyte/macrophage (Mø) immunophenotypic properties, little is known about how such interactions are influenced when MSCs are entrapped within a biomaterial. Furthermore, the impact of the cell-encapsulating matrix on MSC multipotency and on Møs, which infiltrate biomaterials, remains poorly understood. Here we elucidate this three-way interaction. The Mø immunophenotype and MSC differentiation were examined with regard to established and experimental collagen-based biomaterials for MSC entrapment. Tumor necrosis factor-α secretion was acutely inhibited at 4 days. MSCs cocultured with Møs demonstrated attenuated chondrocyte differentiation, whereas osteoblast differentiation was enhanced. Adipocyte differentiation was considerably enhanced for MSCs entrapped within the gelatin/polyethylene glycol-based matrix. A better understanding of the effect of cell encapsulation on differentiation potency and immunomodulation of MSCs is essential for MSC-based, biomaterial-enabled therapies. © AlphaMed Press.
Persistent Identifierhttp://hdl.handle.net/10722/216120
ISSN
2015 Impact Factor: 4.247
2015 SCImago Journal Rankings: 2.049

 

DC FieldValueLanguage
dc.contributor.authorCantu, David Antonio-
dc.contributor.authorHematti, Peiman-
dc.contributor.authorKao, Weiyuan John-
dc.date.accessioned2015-08-25T10:20:54Z-
dc.date.available2015-08-25T10:20:54Z-
dc.date.issued2012-
dc.identifier.citationStem Cells Translational Medicine, 2012, v. 1, n. 10, p. 740-749-
dc.identifier.issn2157-6564-
dc.identifier.urihttp://hdl.handle.net/10722/216120-
dc.description.abstractBone marrow mesenchymal stromal/stem cell (MSC) encapsulation within a biomatrix could improve cellular delivery and extend survival and residence time over conventional intravenous administration. Although MSCs modulate monocyte/macrophage (Mø) immunophenotypic properties, little is known about how such interactions are influenced when MSCs are entrapped within a biomaterial. Furthermore, the impact of the cell-encapsulating matrix on MSC multipotency and on Møs, which infiltrate biomaterials, remains poorly understood. Here we elucidate this three-way interaction. The Mø immunophenotype and MSC differentiation were examined with regard to established and experimental collagen-based biomaterials for MSC entrapment. Tumor necrosis factor-α secretion was acutely inhibited at 4 days. MSCs cocultured with Møs demonstrated attenuated chondrocyte differentiation, whereas osteoblast differentiation was enhanced. Adipocyte differentiation was considerably enhanced for MSCs entrapped within the gelatin/polyethylene glycol-based matrix. A better understanding of the effect of cell encapsulation on differentiation potency and immunomodulation of MSCs is essential for MSC-based, biomaterial-enabled therapies. © AlphaMed Press.-
dc.languageeng-
dc.relation.ispartofStem Cells Translational Medicine-
dc.subjectMultipotential differentiation-
dc.subjectMesenchymal stem cells-
dc.subjectCell biology-
dc.subjectMonocyte-
dc.titleCell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.5966/sctm.2012-0061-
dc.identifier.pmid23197666-
dc.identifier.scopuseid_2-s2.0-84876511512-
dc.identifier.volume1-
dc.identifier.issue10-
dc.identifier.spage740-
dc.identifier.epage749-
dc.identifier.eissn2157-6580-

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