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Conference Paper: Ejection fraction by cardiovascular magnetic resonance predicts adverse outcomes post aortic valve replacement

TitleEjection fraction by cardiovascular magnetic resonance predicts adverse outcomes post aortic valve replacement
Authors
Issue Date2014
PublisherBMJ Group. The publisher's website is located at http://heart.bmj.com/
Citation
The 2014 Annual Conference of the British Cardiovascular Society (BCS), Manchester, UK., 2-4 June 2014. In Heart, 2014, v. 100 suppl 3, p. A53-A54 How to Cite?
AbstractIntroduction Predicting prognosis following aortic valve replacement (AVR) in patients with aortic stenosis (AS) remains challenging. Current guidelines recommend that surgery should be offered when ejection fraction (EF) is <50%. We sought to investigate the prognostic significance of EF calculated by cardiovascular magnetic resonance (CMR) in the long term survival of patients following AVR.Methods 80 patients (69 ± 11 years old at time of surgery; 55 male) scheduled for AVR underwent CMR assessment. 52 patients had severe AS (area <1cm2), 28 patients had moderate AS (area 1.0–1.5cm2) and other qualifying reasons for AVR. 44 patients had additional coronary artery disease.Patients were categorised into three groups according to EF prior to surgery: Group 1 (EF <50%; n = 26), Group 2 (EF of 50–70%; n = 26) and Group 3 (EF >70%; n = 28). A median 5.0 ± 1.8 years follow-up was completed using the National Strategic Tracing Scheme and hospital notes.Results Univariate analysis of all cause mortality using the Kaplan-Meier estimator demonstrated significantly higher mortality in patients with Group 1 (EF <50%) compared to those in group 3 (EF >70%; .03).There was no statistical difference between group 2 (EF of 50–70%) and the remaining 2 groups.Kaplan-Meier survival curve of all cause mortality in Group 1 (EF <50%), Group 2 (EF 50–70%) and Group 3 (EF >70%)Conclusion Pre-operative EF is a significant predictor of mortality following AVR. Patients with EF <50% have the worst prognosis whereas those with EF >70% have the best prognosis. We aim to incease the sample size to determine whether a progressive decrease in EF per se even when above 50% should initiate consideration for AVR.
DescriptionThis free journal suppl. entitled: British Cardiovascular Society Annual Conference 2014 02-04 June 2014, Manchester Central, Manchester
Persistent Identifierhttp://hdl.handle.net/10722/216099
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647

 

DC FieldValueLanguage
dc.contributor.authorVassiliou, V-
dc.contributor.authorChin, C-
dc.contributor.authorPerperoglou, A-
dc.contributor.authorTse, G-
dc.contributor.authorAli, A-
dc.contributor.authorRaphael, C-
dc.contributor.authorJabbour, A-
dc.contributor.authorNewby, D-
dc.contributor.authorPennell, D-
dc.contributor.authorDweck, M-
dc.contributor.authorPrasad, S-
dc.date.accessioned2015-08-24T01:21:16Z-
dc.date.available2015-08-24T01:21:16Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Annual Conference of the British Cardiovascular Society (BCS), Manchester, UK., 2-4 June 2014. In Heart, 2014, v. 100 suppl 3, p. A53-A54-
dc.identifier.issn1355-6037-
dc.identifier.urihttp://hdl.handle.net/10722/216099-
dc.descriptionThis free journal suppl. entitled: British Cardiovascular Society Annual Conference 2014 02-04 June 2014, Manchester Central, Manchester-
dc.description.abstractIntroduction Predicting prognosis following aortic valve replacement (AVR) in patients with aortic stenosis (AS) remains challenging. Current guidelines recommend that surgery should be offered when ejection fraction (EF) is <50%. We sought to investigate the prognostic significance of EF calculated by cardiovascular magnetic resonance (CMR) in the long term survival of patients following AVR.Methods 80 patients (69 ± 11 years old at time of surgery; 55 male) scheduled for AVR underwent CMR assessment. 52 patients had severe AS (area <1cm2), 28 patients had moderate AS (area 1.0–1.5cm2) and other qualifying reasons for AVR. 44 patients had additional coronary artery disease.Patients were categorised into three groups according to EF prior to surgery: Group 1 (EF <50%; n = 26), Group 2 (EF of 50–70%; n = 26) and Group 3 (EF >70%; n = 28). A median 5.0 ± 1.8 years follow-up was completed using the National Strategic Tracing Scheme and hospital notes.Results Univariate analysis of all cause mortality using the Kaplan-Meier estimator demonstrated significantly higher mortality in patients with Group 1 (EF <50%) compared to those in group 3 (EF >70%; .03).There was no statistical difference between group 2 (EF of 50–70%) and the remaining 2 groups.Kaplan-Meier survival curve of all cause mortality in Group 1 (EF <50%), Group 2 (EF 50–70%) and Group 3 (EF >70%)Conclusion Pre-operative EF is a significant predictor of mortality following AVR. Patients with EF <50% have the worst prognosis whereas those with EF >70% have the best prognosis. We aim to incease the sample size to determine whether a progressive decrease in EF per se even when above 50% should initiate consideration for AVR.-
dc.languageeng-
dc.publisherBMJ Group. The publisher's website is located at http://heart.bmj.com/-
dc.relation.ispartofHeart-
dc.titleEjection fraction by cardiovascular magnetic resonance predicts adverse outcomes post aortic valve replacement-
dc.typeConference_Paper-
dc.identifier.emailTse, G: tseg@hku.hk-
dc.identifier.authorityTse, G=rp02073-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1136/heartjnl-2014-306118.93-
dc.identifier.volume100-
dc.identifier.issuesuppl. 3-
dc.identifier.spageA53-
dc.identifier.epageA54-
dc.publisher.placeUnited Kingdom-

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