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Article: Immunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors

TitleImmunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors
Authors
Issue Date2015
PublisherELSEVIER. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description
Citation
Journal of Functional Foods, 2015, v. 13, p. 71-79 How to Cite?
AbstractLactobacillus rhamnosus GG (LGG) is clinically documented in relieving and preventing diarrhea, childhood infections, allergies and atopic eczema but knowledge of its immunomodulatory properties on antigen-presenting cells (APCs) is lacking. Here, immunomodulation of LGG on dendritic cells (DCs), macrophages and monocytes was investigated. Toll-like receptor (TLR) mRNA levels and immunophenotype of LGG-treated APCs, and cytokine secretion levels of culture of LGG-treated DCs and peripheral blood mononuclear cells were examined. LGG reduced TLR 8 mRNA level of APCs, implying that the immunomodulation of LGG may be partly due to the reaction of RNA with APCs. LGG reduced CD16 expression on macrophages and CD11b expression on monocytes. The results obtained demonstrated the effect of LGG on type-1 immune response polarization as observed from elevated production of IL-12 and TNFα across different APC stimulation models, suggesting that LGG may have immunotherapeutic potential in ameliorating and preventing the development of Th2-mediated inflammatory diseases and against infections.
Persistent Identifierhttp://hdl.handle.net/10722/215550

 

DC FieldValueLanguage
dc.contributor.authorFONG, LY-
dc.contributor.authorKirjavainen, PV-
dc.contributor.authorWONG, HY-
dc.contributor.authorEl-Nezamy, HS-
dc.date.accessioned2015-08-21T13:29:56Z-
dc.date.available2015-08-21T13:29:56Z-
dc.date.issued2015-
dc.identifier.citationJournal of Functional Foods, 2015, v. 13, p. 71-79-
dc.identifier.urihttp://hdl.handle.net/10722/215550-
dc.description.abstractLactobacillus rhamnosus GG (LGG) is clinically documented in relieving and preventing diarrhea, childhood infections, allergies and atopic eczema but knowledge of its immunomodulatory properties on antigen-presenting cells (APCs) is lacking. Here, immunomodulation of LGG on dendritic cells (DCs), macrophages and monocytes was investigated. Toll-like receptor (TLR) mRNA levels and immunophenotype of LGG-treated APCs, and cytokine secretion levels of culture of LGG-treated DCs and peripheral blood mononuclear cells were examined. LGG reduced TLR 8 mRNA level of APCs, implying that the immunomodulation of LGG may be partly due to the reaction of RNA with APCs. LGG reduced CD16 expression on macrophages and CD11b expression on monocytes. The results obtained demonstrated the effect of LGG on type-1 immune response polarization as observed from elevated production of IL-12 and TNFα across different APC stimulation models, suggesting that LGG may have immunotherapeutic potential in ameliorating and preventing the development of Th2-mediated inflammatory diseases and against infections.-
dc.languageeng-
dc.publisherELSEVIER. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description-
dc.relation.ispartofJournal of Functional Foods-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in [Journal title]. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, [VOL#, ISSUE#, (DATE)] DOI# -
dc.titleImmunomodulatory effects of Lactobacillus rhamnosus GG on dendritic cells, macrophages and monocytes from healthy donors-
dc.typeArticle-
dc.identifier.emailEl-Nezamy, HS: elnezami@hkucc.hku.hk-
dc.identifier.authorityEl-Nezamy, HS=rp00694-
dc.identifier.doi10.1016/j.jff.2014.12.040-
dc.identifier.hkuros248188-
dc.identifier.volume13-
dc.identifier.spage71-
dc.identifier.epage79-

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