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Conference Paper: MiR-940 may serve as a functional biomarker for detection of gastric cancer
| Title | MiR-940 may serve as a functional biomarker for detection of gastric cancer |
|---|---|
| Authors | |
| Issue Date | 2014 |
| Citation | The 2014 Cell Symposia on Regulatory RNAs, Berkeley, CA., 19-21 October 2014. How to Cite? |
| Abstract | It was reported that miRNAs played significant roles in cancer development. In this study, miR-940 was identified as one of the most downregulated miRNAs in the plasma of patients with gastric cancer. MiR-940 was downregulated in the training and validation set of plasma samples (both P<0.0001). The sensitivity and specificity were 81% and 99%, with an AUC of 0.966, obviously higher than the current biomarkers CEA and CA19-9. MiR-940 was also significantly downregulated in gastric cancer tissue samples (P=0.0015), as well as in gastric cancer cell lines. Importantly, miR-940 was significantly higher expressed in stomach tissues than tissues in liver, breast, thyroid, etc. Target prediction suggested that miR-940 regulated cell signaling including NF-kB and Wnt/β-catenin, as well as cell adhesion and cell-cell interaction. This is the first report that miR-940 may higher express in stomach tissues. Downregulation of plasma miR-940 may serve as a novel functional biomarker for gastric cancer. |
| Description | Poster Session 1: no. P1.06 |
| Persistent Identifier | http://hdl.handle.net/10722/215355 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Liu, X | - |
| dc.contributor.author | Chu, KM | - |
| dc.date.accessioned | 2015-08-21T13:23:06Z | - |
| dc.date.available | 2015-08-21T13:23:06Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | The 2014 Cell Symposia on Regulatory RNAs, Berkeley, CA., 19-21 October 2014. | - |
| dc.identifier.uri | http://hdl.handle.net/10722/215355 | - |
| dc.description | Poster Session 1: no. P1.06 | - |
| dc.description.abstract | It was reported that miRNAs played significant roles in cancer development. In this study, miR-940 was identified as one of the most downregulated miRNAs in the plasma of patients with gastric cancer. MiR-940 was downregulated in the training and validation set of plasma samples (both P<0.0001). The sensitivity and specificity were 81% and 99%, with an AUC of 0.966, obviously higher than the current biomarkers CEA and CA19-9. MiR-940 was also significantly downregulated in gastric cancer tissue samples (P=0.0015), as well as in gastric cancer cell lines. Importantly, miR-940 was significantly higher expressed in stomach tissues than tissues in liver, breast, thyroid, etc. Target prediction suggested that miR-940 regulated cell signaling including NF-kB and Wnt/β-catenin, as well as cell adhesion and cell-cell interaction. This is the first report that miR-940 may higher express in stomach tissues. Downregulation of plasma miR-940 may serve as a novel functional biomarker for gastric cancer. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Cell Symposia on Regulatory RNAs | - |
| dc.title | MiR-940 may serve as a functional biomarker for detection of gastric cancer | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Liu, X: melx1301@hku.hk | - |
| dc.identifier.email | Chu, KM: chukm@hkucc.hku.hk | - |
| dc.identifier.authority | Chu, KM=rp00435 | - |
| dc.identifier.hkuros | 247725 | - |
| dc.identifier.hkuros | 249438 | - |